Knee replacement patients may need fewer steroid doses for better recovery
NCT ID NCT06715709
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares giving one dose of dexamethasone during knee replacement surgery versus two doses (one during surgery and one the next morning). The goal is to see which approach reduces pain, opioid use, and nausea while minimizing complications. About 339 adults undergoing primary knee replacement will participate.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dexamethasone
What this could lead to
If successful, this could establish the safest and most effective dosing schedule for dexamethasone to reduce pain and nausea after knee replacement surgery.
What could go wrong
This is a phase 4 trial focused on symptom management, not a cure. Results may not apply to all patients, and there are risks like infection or adverse reactions to steroids.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States