Knee replacement patients may need fewer steroid doses for better recovery

NCT ID NCT06715709

ENROLLING_BY_INVITATION Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares giving one dose of dexamethasone during knee replacement surgery versus two doses (one during surgery and one the next morning). The goal is to see which approach reduces pain, opioid use, and nausea while minimizing complications. About 339 adults undergoing primary knee replacement will participate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dexamethasone
What this could lead to: If successful, this could establish the safest and most effective dosing schedule for dexamethasone to reduce pain and nausea after knee replacement surgery.
What could go wrong: This is a phase 4 trial focused on symptom management, not a cure. Results may not apply to all patients, and there are risks like infection or adverse reactions to steroids.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHROPATHY OF KNEE

Contacts and locations

Locations

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

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