Can a double-dose of quit-smoking meds help pancreatitis patients kick the habit?
NCT ID NCT07171112
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether increasing the dose of varenicline or adding bupropion helps people with recurrent acute or chronic pancreatitis quit smoking. All 45 participants start with standard varenicline; those still smoking after 6 weeks are randomly assigned to a higher dose, a combination, or continued standard dose. Success is measured by self-report and breath carbon monoxide levels at 12 and 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Varenicline and bupropion
What this could lead to
If successful, this could provide a tailored smoking cessation strategy for people with pancreatitis, potentially reducing disease flares and complications.
What could go wrong
This is a small Phase 2 trial with only 45 participants, so results may not apply broadly. The higher drug doses may cause more side effects, and quitting smoking is difficult even with medication.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55902, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••