Can a fruit compound fight frailty in seniors?

NCT ID NCT03675724

ENROLLING_BY_INVITATION Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 study tests whether fisetin, a natural compound found in fruits like strawberries, can reduce inflammation and frailty in adults aged 70 and older. Forty participants will receive either fisetin or a placebo pill. The goal is to see if fisetin lowers blood markers of inflammation and improves physical function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fisetin (a plant compound found in fruits and vegetables)
What this could lead to: If it works, this could point toward a simple supplement to help older adults feel less frail and reduce inflammation.
What could go wrong: This is a small, early-phase pilot study with only 40 participants, so results may not apply widely. The supplement may not work better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Frailty Inflammation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FRAIL ELDERLY SYNDROME

Contacts and locations

Locations

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

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