Virus therapy targets Hard-to-Treat endometrial cancer

NCT ID NCT03120624

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-stage trial tests a specially modified virus (VSV-hIFNbeta-NIS) given through an IV to people with advanced or recurrent endometrial cancer. The virus is designed to attack cancer cells while leaving healthy cells alone, and it includes a tracer to see where it goes in the body. Some participants also receive a second drug (ruxolitinib) to boost the virus's effect. The main goal is to find the safest dose and check for side effects.

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Conditions

The condition(s) this trial relates to.

carcinosarcoma of the corpus uteri endometrial carcinoma endometrial clear cell adenocarcinoma endometrial endometrioid adenocarcinoma endometrial mixed adenocarcinoma endometrial serous adenocarcinoma endometrial undifferentiated carcinoma endometrium adenocarcinoma endometrium neoplasm uterine corpus cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States