New wristband could shake up essential tremor treatment

NCT ID NCT03778060

Ongoing Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a wristband called Cala TWO that uses mild electrical pulses to calm hand tremors in people with essential tremor. Twenty adults scheduled for deep brain stimulation surgery will use the device twice daily for three months. Researchers will measure tremor severity and daily activity improvements, and a subset will have brain scans to see how the device affects brain activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cala TWO stimulator (transcutaneous peripheral nerve stimulation wristband)
What this could lead to: If it works, this could offer a non-invasive, drug-free option to ease hand tremors for people with essential tremor, potentially reducing the need for risky surgery.
What could go wrong: This is a very small pilot study with only 20 participants, so results may not apply to everyone. The device is meant to ease symptoms temporarily, not cure the condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

essential tremor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESSENTIAL TREMOR

Contacts and locations

Locations

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

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Other studies related to the condition(s) this trial covers.