New combo pain therapy aims to cut opioid use after hip and knee replacements
NCT ID NCT07153003
First seen Nov 01, 2025 · Last updated Jun 18, 2026 · Updated 26 times
Summary
This study compares two pain management approaches after total knee or hip replacement: a combination of tramadol and oxycodone versus oxycodone alone. The goal is to see if the combination reduces the total amount of opioids needed and improves pain control with fewer side effects. About 560 adults having their first joint replacement will participate.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
Conditions
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.