New drug aims to stop transplant complications in blood cancer patients

NCT ID NCT07349771

Not yet recruiting Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase II trial tests whether adding the drug axatilimab to standard care can prevent graft-versus-host disease (GVHD) in 72 blood cancer patients receiving a stem cell transplant. GVHD occurs when donor cells attack the patient's body, causing serious symptoms. Axatilimab is a monoclonal antibody that may block this immune attack. The study compares GVHD-free survival at one year between those getting axatilimab plus standard therapy and those getting a placebo plus standard therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: axatilimab
What this could lead to: If it works, this could lead to a new way to prevent graft-versus-host disease after stem cell transplants, improving outcomes for blood cancer patients.
What could go wrong: This is an early phase II trial with only 72 participants, so results may not apply broadly. The drug may not work better than current treatments or could cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm graft versus host disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOPOIETIC AND LYMPHATIC SYSTEM NEOPLASM

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States

Contact Email: •••••@•••••
Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States

Contact Email: •••••@•••••
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Contact Email: •••••@•••••

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