Nerve block before bypass may stop post-surgery heart flutter

NCT ID NCT07570940

Not yet recruiting Prevention Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a numbing injection around a nerve cluster in the neck, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (irregular heartbeat) in the first week after surgery. About 450 adults scheduled for bypass will be randomly assigned to receive either the numbing drug (liposomal bupivacaine) or a placebo (salt water) injection. Their heart rhythms will be monitored continuously with a wearable ECG device.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: liposomal bupivacaine
What this could lead to: If it works, this could provide a simple, non-drug way to prevent a common and serious heart rhythm problem after bypass surgery.
What could go wrong: This is a single, early-phase 4 trial at one center. The nerve block may not reduce AFib risk, and there are risks from the injection itself, such as bleeding or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder atrial fibrillation prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION CORONARY ARTERY DISEASE

Contacts and locations

Locations

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

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