Mayo clinic pinpoints nonirritating doses for allergy testing of three common anesthesia drugs
NCT ID NCT07103720
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 4 trial at Mayo Clinic tested 21 healthy adults to find the highest skin-testing concentrations of midazolam, ketamine, and ondansetron that do not cause irritation. These drugs are commonly used before, during, and after surgery. The goal is to improve allergy testing accuracy for patients who may have life-threatening reactions during anesthesia.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- midazolam, ketamine, ondansetron
- What this could lead to
- If successful, this study could help doctors safely test for drug allergies during anesthesia, reducing false positives and improving patient safety.
- What could go wrong
- This is a small, completed study in healthy volunteers, so results may not apply to all patients. It only establishes nonirritating concentrations, not treatment or prevention.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mayo Clinic Arizona
Scottsdale, Arizona, 85268, United States
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