Mayo clinic pinpoints nonirritating doses for allergy testing of three common anesthesia drugs
NCT ID NCT07103720
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 4 trial at Mayo Clinic tested 21 healthy adults to find the highest skin-testing concentrations of midazolam, ketamine, and ondansetron that do not cause irritation. These drugs are commonly used before, during, and after surgery. The goal is to improve allergy testing accuracy for patients who may have life-threatening reactions during anesthesia.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
midazolam, ketamine, ondansetron
What this could lead to
If successful, this study could help doctors safely test for drug allergies during anesthesia, reducing false positives and improving patient safety.
What could go wrong
This is a small, completed study in healthy volunteers, so results may not apply to all patients. It only establishes nonirritating concentrations, not treatment or prevention.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic Arizona
Scottsdale, Arizona, 85268, United States