Could a probiotic ease chronic diarrhea? mayo clinic investigates
NCT ID NCT06609148
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a high-dose probiotic (De Simone formulation) can lower bile acid levels in stool and improve diarrhea in people with bile acid malabsorption. Twenty-four adults will take the probiotic or a placebo for about three weeks. Researchers will measure changes in stool bile acids and gut barrier function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- De Simone formulation probiotic (dietary supplement)
- What this could lead to
- If it works, this could point toward a simple probiotic treatment to reduce diarrhea in people with bile acid malabsorption.
- What could go wrong
- This is a very small, early-phase trial with only 24 people. The probiotic may not change bile acid levels or symptoms, and results may not apply to everyone with the condition.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact
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