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Recovering from the ICU: can gentle exercise and nurse coaching at home ease lingering symptoms?

NCT ID NCT06184308

Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial tests whether a home-based program combining gentle physical rehabilitation (flexibility, walking, and breathing exercises) with weekly health coaching calls from a nurse can improve recovery in adults with post-intensive care syndrome (PICS). Many ICU survivors face new or worsening physical, mental, or emotional problems that can last for months. The study aims to see if this practical, at-home approach can boost quality of life and reduce anxiety, depression, and PTSD symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a home-based program combining gentle physical rehabilitation (flexibility, walking, breathing exercises) with weekly health coaching calls from a nurse
What this could lead to
If it works, this could offer a practical, home-based way to improve quality of life and reduce anxiety, depression, and PTSD symptoms in people struggling after an ICU stay.
What could go wrong
This is a small pilot study, so results may not apply broadly. The program requires daily effort, and some people may find it hard to stick with or may not benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

78 people

The number who actually took part.

Started

May 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (age ≥ 18) with PICS defined as admitted to the ICU for more than 48 hours with any of the following conditions: respiratory failure of any cause requiring mechanical ventilation ≥ three days, any shock requiring vasopressors and/or inotropes, development of delirium during the ICU stay, , and cardiac arrest during the index hospital admission. * A HABC-M-SR score \> 12 points. Exclusion Criteria: * Any mechanical ventilation in the last two months before the index ICU admission * ≥ 5 days in the ICU over the previous month before the index ICU admission * Receiving hospice or palliative care * Severe uncontrolled psychological or psychiatric disorders, e.g., schizophrenia, bipolar disorder, struggling to cope as a result of their personality disorder, uncontrolled substance abuse (alcoholism, illegal drugs) homelessness would make them unsuitable for the intervention * A co-morbidity so severe it would prevent the patient from engaging fully in the intervention/ control, e.g., progressive cancer, anoxic brain injury, severe rheumatoid arthritis or osteoarthritis, multiple sclerosis, chronic widespread pain syndrome, previous cerebral vascular event that the patient would not be able to participate in PR * Patients with moderate/severe cognitive impairment per medical records screening * Inability to obtain informed consent.

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Conditions

The condition(s) this trial relates to.

postintensive care syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post intensive care syndrome

Contacts and locations

Locations

  • Mayo Clinic Arizona

    Scottsdale, Arizona, 85259, United States

  • Mayo Clinic Minnesota

    Rochester, Minnesota, 55905, United States

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