Scientists investigate the roots of persistent Post-Concussion headaches

NCT ID NCT04369729

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This completed study looked at 101 adults who developed headaches within 7 to 56 days after a mild head injury. Researchers used brain scans, blood tests, and pain sensitivity tests to find clues about who might develop long-term headaches. The goal was to better understand the mechanisms behind persistent post-traumatic headache, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this research could point toward ways to predict and prevent long-term headaches after a mild head injury.

What could go wrong

This is an observational study, not a treatment trial. It aims to understand the problem, not test a cure or therapy.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Post-Traumatic Headache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Mayo Clinic

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic

    Scottsdale, Arizona, 85259, United States

  • Mayo Clinic

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic

    Rochester, Minnesota, 55901, United States

  • Phoenix VA Health Care System

    Phoenix, Arizona, 85012, United States