Can a Mega-Dose of water pills help heart failure patients?

NCT ID NCT06036914

Completed Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a very high dose of the diuretic bumetanide can remove more fluid than standard doses of furosemide in people hospitalized with worsening heart failure. Twenty patients received either the ultra-high dose or the usual dose over 24 hours. The goal was to see if the stronger dose safely increases urine output and improves symptoms like swelling and shortness of breath.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Bumetanide (ultra-high dose diuretic) and Furosemide (standard dose diuretic)
What this could lead to: If it works, this could point toward a more effective way to quickly remove excess fluid in heart failure patients, potentially reducing hospital stay and symptoms.
What could go wrong: This is a very small pilot study with only 20 participants, so results may not apply to everyone. High-dose diuretics can also cause kidney problems or electrolyte imbalances.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

congestive heart failure heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE; WITH DECOMPENSATION

Contacts and locations

Locations

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

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