New radiation schedule before breast surgery shows promise in small trial
NCT ID NCT03624478
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tested giving a higher dose of radiation over fewer sessions (hypofractionated radiotherapy) to the whole breast before surgery in 25 women with early-stage breast cancer. The goal was to see if this approach could kill more tumor cells and cause fewer side effects compared to standard radiation. Researchers measured how many patients had no cancer left in the surgical specimen (pathologic complete response) and tracked any side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Hypofractionated radiation therapy
What this could lead to
If successful, this approach could offer a more convenient and effective radiation schedule before breast cancer surgery, potentially reducing side effects and improving tumor clearance.
What could go wrong
This is a small, early-phase trial with only 25 participants, so results may not apply broadly. The higher radiation dose could also increase short-term side effects.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Mayo Clinic in Arizona
Scottsdale, Arizona, 85259, United States
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Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980, United States