New brain scan tracks Dementia-Linked tau buildup in rare language disorders
NCT ID NCT02736695
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a special PET scan tracer (F-18 AV 1451) to see how much tau protein builds up in the brains of 81 people with primary progressive aphasia or frontotemporal dementia. Researchers compared these scans to those of healthy controls to find unique patterns for each disease subtype. The goal was to improve understanding and diagnosis, not to test a treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- F-18 AV 1451 (a radioactive tracer for PET scans)
- What this could lead to
- If successful, this could help doctors better diagnose and distinguish different types of frontotemporal dementia and primary progressive aphasia using brain scans.
- What could go wrong
- This is an early-phase, observational study focused on imaging, not a treatment trial. The tracer may not reliably distinguish all subtypes, and results may not directly improve patient care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BEHAVIORAL VARIANT OF FRONTOTEMPORAL DEMENTIA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mayo Clinic
Rochester, Minnesota, 55905, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a nudge in your chart unlock Life-Saving genetic clues?
- Can retraining word meanings restore lost speech?
- Could a brain disease change behavior years before diagnosis?
- Smart bracelets could read the hidden signs of apathy in dementia
- Can a synthetic cannabinoid calm agitation in frontotemporal dementia?
- Can sound waves soothe Dementia's emotional turmoil?