New drug cocktail shows promise in shrinking advanced melanoma before surgery
NCT ID NCT03554083
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial tested a combination of targeted drugs (vemurafenib and cobimetinib) and immunotherapy (atezolizumab and tiragolumab) given before surgery to 64 patients with high-risk stage III melanoma. The goal was to see if the treatment could eliminate or shrink the cancer enough to improve outcomes. The study measured how many patients had no cancer left at surgery and how long they stayed cancer-free afterward.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vemurafenib, cobimetinib, atezolizumab, and tiragolumab
What this could lead to
If successful, this could point toward a more effective way to shrink high-risk stage III melanoma before surgery, potentially reducing the chance of the cancer coming back.
What could go wrong
This is a small, early-phase pilot trial with only 64 participants, so results may not apply to everyone. The combination of drugs can cause significant side effects, and it's not yet clear if it improves long-term survival.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, 55455, United States