One-shot heart fix: two procedures combined in single session for AFib and valve leak
NCT ID NCT04494347
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether it is safe and feasible to perform two heart procedures—MitraClip to repair a leaky mitral valve and Watchman to close off a part of the heart linked to stroke risk—in one session. The trial enrolled 25 adults with both severe mitral regurgitation and atrial fibrillation. Researchers tracked deaths and serious complications like stroke or major bleeding to assess the combined approach.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- MitraClip device and Watchman device
- What this could lead to
- If successful, this combined procedure could simplify treatment for patients with both conditions, reducing the need for separate surgeries.
- What could go wrong
- This was a small, early feasibility study with only 25 participants, so results may not apply broadly. Combining procedures may increase risks like bleeding or stroke.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Ottawa Heart Institute
Ottawa, Ontario, K1Y 4W7, Canada
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