Brain scans aim to uncover Tau's role in rare Parkinson's-Like disease

NCT ID NCT02605785

Recruiting now Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses special PET scans to measure tau protein buildup in the brains of 332 people with Progressive Supranuclear Palsy (PSP), a rare brain disorder that affects movement and balance. Researchers want to see how tau levels change over time and relate to symptoms. Participants must be over 35 and have a study partner who can provide information about their daily functioning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: F-18 AV 1451 (tau PET scan tracer)
What this could lead to: If successful, this could help doctors better understand how tau buildup relates to PSP symptoms and track disease progression over time.
What could go wrong: This is an observational imaging study, not a treatment trial. It may not directly lead to new therapies, and results may not apply to all PSP patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

progressive supranuclear palsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROGRESSIVE SUPRANUCLEAR PALSY

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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