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New combo may help more lymphoma patients reach potentially curative CAR-T

NCT ID NCT06834373

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving two drugs, golcadomide and rituximab, before CAR-T cell therapy can help control aggressive B-cell non-Hodgkin lymphoma that has returned or not responded to prior treatment. The goal is to keep the disease in check so more patients can qualify for CAR-T, which offers a chance for long-term control. About 41 adults with relapsed or refractory lymphoma will receive this bridging therapy and be monitored for response.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma diffuse large B-cell lymphoma activated B-cell type diffuse large B-cell lymphoma germinal center B-cell type

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LARGE B-CELL LYMPHOMA WITH IRF4 REARRANGEMENT RECURRENT AGGRESSIVE B-CELL NON-HODGKIN LYMPHOMA RECURRENT ALK POSITIVE LARGE B-CELL LYMPHOMA RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA ACTIVATED B-CELL TYPE RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA ASSOCIATED WITH CHRONIC INFLAMMATION RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA GERMINAL CENTER B-CELL TYPE RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED RECURRENT EBV-POSITIVE DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED RECURRENT GRADE 3B FOLLICULAR LYMPHOMA RECURRENT HIGH GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 REARRANGEMENTS RECURRENT HIGH GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED RECURRENT INTRAVASCULAR LARGE B-CELL LYMPHOMA RECURRENT PRIMARY CUTANEOUS DIFFUSE LARGE B-CELL LYMPHOMA, LEG TYPE RECURRENT PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA RECURRENT T-CELL/HISTIOCYTE-RICH LARGE B-CELL LYMPHOMA RECURRENT TRANSFORMED NON-HODGKIN LYMPHOMA REFRACTORY AGGRESSIVE B-CELL NON-HODGKIN LYMPHOMA REFRACTORY ALK POSITIVE LARGE B-CELL LYMPHOMA REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA ACTIVATED B-CELL TYPE REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA ASSOCIATED WITH CHRONIC INFLAMMATION REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA GERMINAL CENTER B-CELL TYPE REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED REFRACTORY EBV-POSITIVE DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED REFRACTORY GRADE 3B FOLLICULAR LYMPHOMA REFRACTORY HIGH GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 REARRANGEMENTS REFRACTORY HIGH GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED REFRACTORY INTRAVASCULAR LARGE B-CELL LYMPHOMA REFRACTORY PRIMARY CUTANEOUS DIFFUSE LARGE B-CELL LYMPHOMA, LEG TYPE REFRACTORY PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA REFRACTORY T-CELL/HISTIOCYTE-RICH LARGE B-CELL LYMPHOMA REFRACTORY TRANSFORMED NON-HODGKIN LYMPHOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Mayo Clinic Health System in Albert Lea

    RECRUITING

    Albert Lea, Minnesota, 56007, United States

    Contact Email: •••••@•••••

  • Mayo Clinic Health System-Eau Claire Clinic

    RECRUITING

    Eau Claire, Wisconsin, 54701, United States

    Contact Email: •••••@•••••

  • Mayo Clinic Health System-Franciscan Healthcare

    RECRUITING

    La Crosse, Wisconsin, 54601, United States

    Contact Email: •••••@•••••

  • Mayo Clinic Health Systems-Mankato

    RECRUITING

    Mankato, Minnesota, 56001, United States

    Contact Email: •••••@•••••

  • Mayo Clinic in Arizona

    RECRUITING

    Scottsdale, Arizona, 85259, United States

    Contact Email: •••••@•••••

  • Mayo Clinic in Florida

    RECRUITING

    Jacksonville, Florida, 32224-9980, United States

    Contact Email: •••••@•••••

  • Mayo Clinic in Rochester

    RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact Email: •••••@•••••

More trials for these conditions

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