New combo therapy aims to stop aggressive lymphoma relapse

NCT ID NCT06271057

Recruiting now Disease control Sponsor: The Lymphoma Academic Research Organisation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a drug called golcadomide after standard CAR T-cell therapy can prevent aggressive large B-cell lymphoma from returning in patients at high risk of relapse. About 65 adults will receive golcadomide for 24 weeks starting 5 days after their CAR T-cell infusion. The main goal is to see if more patients achieve a complete response (no cancer detected) at 3 months.

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Conditions

The condition(s) this trial relates to.

B-cell non-Hodgkin lymphoma diffuse large B-cell lymphoma follicular lymphoma high grade B-cell lymphoma marginal zone lymphoma primary mediastinal large B-cell lymphoma relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE LARGE B CELL LYMPHOMA REFRACTORY REFRACTORY HIGH-GRADE B-CELL LYMPHOMA REFRACTORY PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA REFRACTORY TRANSFORMED B-CELL NON-HODGKIN LYMPHOMA

Contacts and locations

Locations

Centre Henri Becquerel
RECRUITING

Rouen, 76038, France
Chru de Lille
RECRUITING

Lille, 59037, France
Chu Brabois
RECRUITING

Vandœuvre-lès-Nancy, 54511, France
Chu Dijon Bourgogne
RECRUITING

Dijon, 21000, France
Chu Pontchaillou
RECRUITING

Rennes, 35033, France
Chu de Bordeaux
RECRUITING

Pessac, 33604, France
Chu de Grenoble
RECRUITING

La Tronche, 38700, France
Chu de Montpellier
RECRUITING

Montpellier, 34090, France
Chu de Nantes
RECRUITING

Nantes, 44093, France
Hopital Henri Mondor
RECRUITING

Créteil, 94010, France
Hopital Saint-Louis
RECRUITING

Paris, 75475, France
Institut Paoli Calmettes
RECRUITING

Marseille, 13273, France
Iuct Oncopole
RECRUITING

Toulouse, 31059, France

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