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Could your own immune cells fight liver cancer? new trial aims to find out

NCT ID NCT03942328

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study tests a new approach for people with advanced liver cancer that cannot be surgically removed. Participants receive radiation followed by an injection of their own specially trained immune cells (dendritic cells), a pneumonia vaccine to boost immunity, and immunotherapy drugs. The goal is to see if this combination is safe and can help the body attack the tumor. The trial is currently recruiting 85 adults with specific types of liver cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
autologous dendritic cells (immune cells grown from the patient's own blood), Prevnar (pneumonia vaccine), atezolizumab, durvalumab, bevacizumab
What this could lead to
If it works, this could point toward a new treatment option for people with liver cancer that cannot be removed by surgery.
What could go wrong
This is an early-phase trial with only 85 participants, so results may not apply to everyone. The combination therapy may cause significant side effects or fail to improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cholangiocarcinoma hepatocellular carcinoma intrahepatic cholangiocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STAGE III HEPATOCELLULAR CARCINOMA AJCC V8 STAGE III INTRAHEPATIC CHOLANGIOCARCINOMA AJCC V8 STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8 STAGE IV INTRAHEPATIC CHOLANGIOCARCINOMA AJCC V8 UNRESECTABLE HEPATOCELLULAR CARCINOMA UNRESECTABLE INTRAHEPATIC CHOLANGIOCARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Mayo Clinic in Rochester

    RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact Email: •••••@•••••

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