Which painkiller works best after gynecologic cancer surgery? new trial aims to find out
NCT ID NCT06525740
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two opioid pain medicines—methadone given through an IV and hydromorphone injected into the spine—for pain relief after gynecologic cancer surgery. About 140 women will take part, and researchers will measure their pain scores and side effects like itching and breathing problems. The goal is to see if methadone works as well as the spinal injection for controlling pain after a major abdominal surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Methadone and hydromorphone
What this could lead to
If successful, this could show that methadone is as good as or better than intrathecal hydromorphone for pain control after gynecologic cancer surgery, potentially simplifying pain management.
What could go wrong
This is a small, early-phase trial (140 participants) comparing two existing drugs, so it won't produce a new treatment. Results may not apply to all patients or surgeries.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MALIGNANT FEMALE REPRODUCTIVE SYSTEM NEOPLASM are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact