Could less be more? new trial tests lighter hormone therapy for prostate cancer
NCT ID NCT06369610
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether giving fewer hormone therapy drugs (abiraterone acetate and GnRH analogs) along with radiation can work as well as longer treatment for high-risk prostate cancer that has spread a little. The goal is to reduce side effects while still controlling the cancer. About 110 participants will receive a risk-tailored, shorter course of hormone therapy plus radiation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- abiraterone acetate (Zytiga) and gonadotropin-releasing hormone analogs
- What this could lead to
- If successful, this could show that a shorter, less intense hormone therapy combined with radiation is just as effective as longer treatment, with fewer side effects for high-risk prostate cancer patients.
- What could go wrong
- This is a phase 2 trial with only 110 participants, so results are preliminary. It may not prove that de-escalated treatment is as effective as standard care, and some patients might still need more intensive therapy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Mayo Clinic in Arizona
RECRUITINGScottsdale, Arizona, 85259, United States
Contact Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can surgery boost control of spread prostate cancer?
- Can a better scan sharpen radiation for prostate cancer?
- Hormone therapy showdown: can an oral pill beat the shot for prostate cancer patients?
- Can tracking tumor movement during radiation make treatment more precise?
- Can a single small incision preserve sexual function after prostate cancer surgery?
- Can a shorter course of radiation tame prostate cancer with fewer side effects?