Can two common compounds supercharge CAR-T against myeloma?
NCT ID NCT06940297
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial at Mayo Clinic is testing whether adding dasatinib and quercetin to standard CAR-T therapy can improve outcomes for people with multiple myeloma that has returned or not responded to prior treatments. The study will enroll 44 adults who have already tried at least three other therapies. Participants receive the drug combination along with chemotherapy and CAR-T cells, and researchers will measure how many achieve undetectable cancer levels.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dasatinib and quercetin
What this could lead to
If successful, this combination could improve the effectiveness of CAR-T therapy for multiple myeloma, helping more patients achieve deep remission.
What could go wrong
This is a small, early-phase trial with only 44 participants. The added benefit of dasatinib and quercetin is unproven, and side effects from the combination are not yet well understood.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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