Probiotic may counteract gut bacteria changes from common heartburn drug
NCT ID NCT05517928
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether taking the probiotic Lactobacillus rhamnosus GG (found in Culturelle) can prevent or reverse changes in gut bacteria caused by the acid reflux drug omeprazole. Researchers will give 30 healthy adults omeprazole plus either the probiotic or a placebo for several weeks, then compare stool samples to see how gut microbes differ. The goal is to understand if probiotics can help maintain a healthy gut during PPI therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Lactobacillus rhamnosus GG (probiotic) and omeprazole (acid reflux drug)
What this could lead to
If it works, this could point toward a simple probiotic supplement to protect gut health in people who need long-term acid reflux medication.
What could go wrong
This is a very small, early exploratory study in healthy people, not patients. It only measures gut bacteria changes, not health outcomes, so real benefits remain uncertain.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic Arizona
RECRUITINGScottsdale, Arizona, 85259, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••