Probiotic may counteract gut bacteria changes from common heartburn drug

NCT ID NCT05517928

Recruiting now Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking the probiotic Lactobacillus rhamnosus GG (found in Culturelle) can prevent or reverse changes in gut bacteria caused by the acid reflux drug omeprazole. Researchers will give 30 healthy adults omeprazole plus either the probiotic or a placebo for several weeks, then compare stool samples to see how gut microbes differ. The goal is to understand if probiotics can help maintain a healthy gut during PPI therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lactobacillus rhamnosus GG (probiotic) and omeprazole (acid reflux drug)
What this could lead to: If it works, this could point toward a simple probiotic supplement to protect gut health in people who need long-term acid reflux medication.
What could go wrong: This is a very small, early exploratory study in healthy people, not patients. It only measures gut bacteria changes, not health outcomes, so real benefits remain uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY

Contacts and locations

Locations

Mayo Clinic Arizona
RECRUITING

Scottsdale, Arizona, 85259, United States

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