Fat-Derived stem cells injected into brain during surgery to fight glioblastoma

NCT ID NCT05789394

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests whether stem cells taken from fat tissue can be safely injected into the brain during surgery for recurrent glioblastoma. The stem cells are meant to attack remaining tumor cells and make them more sensitive to chemotherapy. About 20 adults whose brain cancer has returned will receive the treatment, and researchers will look for side effects and the best dose to use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: allogeneic adipose-derived mesenchymal stem cells (AMSCs)
What this could lead to: If it works, this could point toward a new way to slow or stop recurrent glioblastoma by delivering stem cells directly into the brain during surgery.
What could go wrong: This is a very early Phase 1 trial with only 20 people, focused on safety and dosing. It may not show any benefit, and there are risks from the surgery and the stem cell injection itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

astrocytoma (excluding glioblastoma) astrocytoma, IDH-mutant, grade 4 glioblastoma IDH-wildtype glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTROCYTOMA, GRADE IV RECURRENT ASTROCYTOMA, IDH-MUTANT, GRADE 4 RECURRENT GLIOBLASTOMA, IDH-WILDTYPE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Mayo Clinic in Florida
RECRUITING

Jacksonville, Florida, 32224-9980, United States

Contact Email: •••••@•••••

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