Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a common drug make head and neck cancer treatment more effective?

NCT ID NCT06997094

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 16, 2026 · Updated 2 times

Summary

This early-stage trial is testing the safety and best dose of the drug decitabine when added to standard surgery, radiation, and chemotherapy for people with HPV-negative head and neck cancer that can be surgically removed. Decitabine may help make cancer cells more sensitive to standard treatments. The study involves 24 participants and aims to find the highest safe dose and check for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Decitabine
What this could lead to
If successful, this could make standard treatments like chemotherapy and radiation more effective for HPV-negative head and neck cancer, potentially improving survival.
What could go wrong
This is an early phase I trial with only 24 participants, focused on safety and dosing. It may not lead to a proven treatment, and decitabine can cause serious side effects like low blood counts.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for HPV-NEGATIVE SQUAMOUS CELL CARCINOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HPV-NEGATIVE SQUAMOUS CELL CARCINOMA HUMAN PAPILLOMAVIRUS-NEGATIVE NECK SQUAMOUS CELL CARCINOMA RESECTABLE HEAD AND NECK SQUAMOUS-CELL CARCINOMA RESECTABLE HUMAN PAPILLOMAVIRUS-INDEPENDENT HEAD AND NECK MUCOSAL SQUAMOUS CELL CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Mayo Clinic in Florida

    RECRUITING

    Jacksonville, Florida, 32224-9980, United States

    Contact Email: •••••@•••••

More trials for these conditions

Other studies related to the condition(s) this trial covers.