Could your heartburn meds cause gut bacteria overgrowth? new study investigates
NCT ID NCT05976165
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is looking at whether people who take proton pump inhibitors (PPIs) for heartburn or acid reflux develop an overgrowth of bacteria in the small intestine. Researchers will use a simple breath test to check for this condition. The goal is to learn how common this problem is and how it relates to symptoms like bloating.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Breath testing (carbohydrate solution)
What this could lead to
If successful, this could help doctors understand whether PPIs raise the risk of SIBO and guide better management of heartburn.
What could go wrong
This is a small, early observational study with only 50 participants, so results may not apply to everyone. Breath testing is not a direct treatment.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic Florida
RECRUITINGJacksonville, Florida, 32224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••