Could your heartburn meds cause gut bacteria overgrowth? new study investigates

NCT ID NCT05976165

Recruiting now Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is looking at whether people who take proton pump inhibitors (PPIs) for heartburn or acid reflux develop an overgrowth of bacteria in the small intestine. Researchers will use a simple breath test to check for this condition. The goal is to learn how common this problem is and how it relates to symptoms like bloating.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Breath testing (carbohydrate solution)
What this could lead to: If successful, this could help doctors understand whether PPIs raise the risk of SIBO and guide better management of heartburn.
What could go wrong: This is a small, early observational study with only 50 participants, so results may not apply to everyone. Breath testing is not a direct treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastroesophageal reflux disease Heartburn

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROESOPHAGEAL REFLUX HEARTBURN REGURGITATION

Contacts and locations

Locations

Mayo Clinic Florida
RECRUITING

Jacksonville, Florida, 32224, United States

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