Can fixing reflux fix your esophagus? new study investigates

NCT ID NCT05132816

Recruiting now Knowledge-focused Sponsor: Prof Urs Zingg Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether weak esophageal contractions (ineffective motility) improve after partial fundoplication surgery for gastroesophageal reflux. Researchers will perform high-resolution manometry 18-24 months after surgery in 100 patients who had weak contractions before surgery. The goal is to see if the surgery helps restore normal esophageal function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could show that reflux causes weak esophageal contractions, and that surgery may restore normal function, guiding better treatment decisions.
What could go wrong: This is a small, single-center study with no control group, so results may not apply to all patients. It only measures changes, not whether symptoms improve.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

digestive system disorder dyskinesia of esophagus gastroesophageal reflux disease upper digestive tract disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL MOTILITY DISORDERS GASTROESOPHAGEAL REFLUX UPPER GASTROINTESTINAL DISORDER

Can fixing reflux fix your esophagus? new study investigates

Summary

What this could mean

Get notified about this study

Conditions

As listed by the trial registrant

Contacts and locations

Locations

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