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Hunting the DNA clues that raise Barrett's esophagus risk

NCT ID NCT00445653

Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 07, 2026 · Last updated Oct 08, 2026 · Updated 1 time

Summary

Researchers at Massachusetts General Hospital are studying whether certain DNA variations and health factors raise the risk of Barrett's esophagus, a condition that can precede esophageal cancer. The study enrolls about 170 people who are having an upper endoscopy to check Barrett's esophagus, to evaluate severe acid reflux or chest pain, or to investigate gastrointestinal bleeding. Participants provide DNA and health information, and researchers compare gene variants involved in detoxifying chemicals, inflammation, and DNA repair between people with and without the condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If researchers identify gene variants linked to Barrett's esophagus, doctors could one day flag who needs closer screening before precancerous changes take hold.
What could go wrong
This study only looks for statistical links between genes and a condition. It cannot prove that any gene causes Barrett's esophagus, and the findings may not apply to people outside this group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

170 people

The number who actually took part.

Start date

Aug 2005

Finished

Mar 2013

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients coming in for EGD

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

DISEASE CHARACTERISTICS: * Undergoing elective esophagogastroduodenoscopy for any of the following reasons: * Surveillance of Barrett's esophagus * Evaluation of severe or refractory gastroesophageal reflux disease or chest pain thought to be due to reflux * Gastrointestinal bleeding PATIENT CHARACTERISTICS: * Not pregnant PRIOR CONCURRENT THERAPY: * Not specified

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Conditions

The condition(s) this trial relates to.

Barrett esophagus gastroesophageal reflux disease precancerous condition

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Precancerous condition

Contacts and locations

Locations

  • Harvard School of Public Health

    Boston, Massachusetts, 02115, United States

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts, 02114, United States

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