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Can a radiofrequency zap calm stubborn heartburn?

NCT ID NCT01682265

Symptom relief Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Many people with gastroesophageal reflux disease still have heartburn even when they take proton pump inhibitors. The SIRUP trial compares the Stretta procedure, which uses radiofrequency energy on the esophagus, with a sham procedure in adults who have at least three heartburn episodes a week despite medication. Researchers measure whether participants need acid blockers less often and get adequate symptom relief six months later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Stretta procedure, a radiofrequency treatment applied to the esophagus
What this could lead to
If it works, the Stretta procedure could offer people whose heartburn persists on acid-blocking drugs a way to control symptoms without daily medication.
What could go wrong
This is a small, blinded trial of a procedure that has shown mixed results in other studies. The sham control means any benefit must clearly beat a placebo effect, and procedures carry risks like chest pain or injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

62 people

The number who actually took part.

Started

Mar 2012

Finished

Nov 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 ans * Severe or moderate heartburn (at least 3 heartburn times per week), persistent under treatment with IPP Exclusion Criteria: * Recent oeso-gastro-duodenal endoscopy(\< 3 months) * Oesophagitis \> grade A * Endobrachyoesophagus \> C0M1 * Hiatal Hernia \> 2 cm * Symptoms insufficiently relieved with continued intake of IPP or with intake of IPP according to needs * Predominant symptom of Gastrooesophageal reflux disease other than heartburn * Patients contra-indicated for radiofrequency technique * Pregnant women

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Conditions

The condition(s) this trial relates to.

gastroesophageal reflux disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gastroesophageal reflux disease

Contacts and locations

Locations

  • APHP - Louis Mourier hospital

    Colombes, 92700, France

  • Bordeaux Universitary Hospital

    Bordeaux, France

  • Brest universitary hospital

    Brest, 29200, France

  • Lyon Universitary Hospital

    Lyon, 69000, France

  • Nantes Universitary Hospital

    Nantes, Loire Atlantique, 44093, France

  • Rouen Universitary Hospital

    Rouen, 76000, France

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