Upper digestive tract disorder

This study tests a personalized vaccine created from a patient's own immune cells (dendritic cells) that are trained to attack unique markers on their tumor. It is for people with advanced solid tumors who have not responded to standard treatments. The main goal is to check safet…

This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…

This study tests whether a stronger chemotherapy mix (mFOLFIRINOX) works better than the standard mix (FOLFOX) for people with advanced stomach, esophageal, or gastroesophageal junction cancer that cannot be removed by surgery. Some participants also receive the immunotherapy dru…

This study tests a drug called I-DXd in 60 people with advanced esophageal cancer that has worsened after prior treatments. I-DXd is designed to attach to cancer cells and deliver a toxic payload to destroy them. The main goal is to see how many patients' tumors shrink or disappe…

This study tests a new drug called TQB6411 in people with advanced esophageal cancer that has worsened after standard treatments. The drug is designed to target and attack cancer cells. The trial has two parts: first to find a safe dose, then to see if it shrinks tumors. About 10…

This study looks at a second surgery for people who had gastric bypass but still suffer from severe acid reflux that medication can't control. The procedure wraps part of the stomach to stop reflux. Researchers will follow 17 adults for up to 2 years to see if the surgery works a…

This clinical trial is testing whether adding the immunotherapy drug nivolumab to standard chemotherapy (paclitaxel and ramucirumab) can help people with advanced stomach or esophageal cancer live longer. The study includes 224 adults whose cancer has a specific marker (PD-L1 CPS…

This study investigates the safety and symptom-relieving effects of the drug Tegoprazan (K-CAB) in adults with gastroesophageal reflux disease (GERD). Researchers will track how well the drug reduces heartburn and acid reflux after 4 weeks of use. The study includes over 5,000 pa…

This Phase 3 trial is testing whether a new targeted drug called sonesitatug vedotin, combined with chemotherapy (capecitabine) and possibly an immunotherapy (rilvegostomig), can help people with advanced stomach, gastroesophageal junction, or esophageal cancer that has a specifi…

This pilot trial tests whether feeding directly into the small intestine (transpyloric) is better than feeding into the stomach (gastric) for very preterm infants with bronchopulmonary dysplasia, a chronic lung condition. The study will measure how often babies have low oxygen le…

This study tests a new drug called DR30206 combined with standard treatments for people with advanced or spreading gastrointestinal cancers, like colorectal cancer. The goal is to see if the combination is safe and can shrink tumors. About 186 adults in China will take part.

This study tests a new device called EndoRotor, which mechanically removes the damaged lining of the esophagus, against the standard heat-based radiofrequency treatment for people with Barrett's esophagus who have precancerous cells (dysplasia). The goal is to see if the new meth…

This study tests a new drug called ALE.P02 in people with advanced squamous cell cancers of the lung, head and neck, cervix, or esophagus that have spread or cannot be removed. The goal is to find the safest and most effective dose and see if it can shrink tumors. About 170 adult…

This trial compares two endoscopic procedures—endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD)—for removing visible precancerous lesions in people with Barrett's esophagus. About 331 adults with Barrett's esophagus and early-stage abnormal tissue will…

This study tests whether feeding preterm infants with chronic lung disease through a tube placed past the stomach (into the small intestine) helps their breathing more than feeding through a tube in the stomach. About 50 high-risk preterm babies born before 32 weeks will receive …

This study tests new drug combinations (including an antibody-drug conjugate) with the immunotherapy pembrolizumab, with or without chemotherapy, for people with advanced esophageal cancer that cannot be removed by surgery or has spread. About 298 participants will join to see if…

This study is testing the drug T-DXd (Enhertu) in 100 adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. The goal is to see how well the drug works in real-world settings, including how many patients respond and …

This study tests several new drug combinations, with or without the immunotherapy pembrolizumab, in people with advanced esophageal cancer that has continued to grow after standard treatment. About 230 participants will receive different drug regimens to see which are safest and …

This study compares two drug combinations for people with advanced stomach, gastroesophageal junction, or esophageal cancer that hasn't been treated yet. One group gets pumitamig plus chemotherapy, the other gets nivolumab plus chemotherapy. The goal is to see which combo works b…

This phase 2 trial is testing whether adding common diabetes drugs (metformin or rosiglitazone) to standard immunotherapy (nivolumab or pembrolizumab) can improve treatment for several advanced solid tumors, including melanoma, lung cancer, and liver cancer. About 72 participants…

This study compares three approaches for treating GERD in NICU infants: letting the condition improve naturally, using the drug omeprazole, or using a special added rice formula. Researchers will track 369 babies to see which treatment leads to better feeding and fewer symptoms l…

This study tests an experimental oral drug called zongertinib, which blocks HER2, a protein that fuels cancer growth. It is given alone or with other cancer drugs to adults with advanced HER2+ breast, stomach, or colorectal cancer that has spread and not responded to prior treatm…

This phase 2 trial is testing a combination of three chemotherapy drugs plus immunotherapy as a first treatment for advanced esophageal and gastric cancer. For patients with HER2-positive tumors, the targeted drug trastuzumab is also added. The study aims to see if this mix is mo…

This early-stage trial is testing a new drug called IDE892, alone or with another drug (IDE397), in people with advanced solid tumors that have a specific genetic deletion (MTAP). The study aims to find safe doses and see if the drugs shrink tumors. It includes 260 adults with ca…

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This study compares two radiation techniques for people with stage I to IVA esophageal cancer: proton beam therapy (which uses protons) and intensity modulated photon radiotherapy (which uses X-rays). The goal is to see which one works better at helping people live longer and cau…

This early-stage trial tests an experimental drug called SAR445877, alone or with other cancer drugs, in adults with advanced solid tumors that have spread or cannot be removed. The study has two parts: first, finding a safe dose, and second, checking if the drug shrinks tumors. …

This study is testing a drug called tislelizumab combined with chemotherapy as a first treatment for people with advanced stomach or esophageal cancer that cannot be removed by surgery or has spread. It focuses on racial and ethnic minority groups in the US, including Black, Hisp…

This trial tests whether a new robotic system that uses only one small incision (single port) can safely perform common abdominal surgeries in children. The study includes children aged 1 to 17 who need procedures like pyeloplasty or reflux treatment. The goal is to see if the si…

This phase 2 trial tests whether a series of procedures to remove cancerous tumors, given one after another, can improve outcomes for people with stage IV foregut cancers (like stomach, pancreas, or bile duct cancer) who have no detectable cancer DNA in their blood after initial …

This early study tests an experimental drug called XB010, alone or combined with the immunotherapy pembrolizumab, in people with advanced solid tumors (like lung, breast, or head and neck cancers) that have stopped responding to other treatments. The main goals are to find a safe…

This study tests a new way to give chemotherapy for gastrointestinal cancers like colorectal and stomach cancer. Doctors will adjust the dose of one chemo drug (5-FU) based on how well each patient tolerates it, aiming to give higher doses to those who can handle it without sever…

This early-stage trial tests a new drug called LY4052031, which is designed to deliver a cancer-killing agent directly to tumor cells that have a protein called Nectin-4. The study includes 420 adults with advanced or metastatic solid tumors such as bladder, breast, lung, and oth…

This study tests whether adding a single, low dose of radiation to the small intestine can make a standard immunotherapy-plus-chemotherapy regimen work better for people with esophageal cancer that cannot be easily removed by surgery. About 43 adults with borderline resectable or…

This study tests whether a smartphone app called GERDCare can help people with GERD (acid reflux) take their medication and follow lifestyle advice more consistently. About 380 adults with typical reflux symptoms will use the app for four weeks, and researchers will measure how w…

This study tests the drug dupilumab in children as young as 6 months who have active eosinophilic esophagitis (EoE), a condition that causes inflammation in the esophagus and can make eating difficult. The goal is to see if the drug is safe and effective over 24 weeks. About 20 c…

This early-phase study is testing an experimental drug called IDE034 in 150 adults with advanced solid tumors (such as lung, ovarian, or colorectal cancer) that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see …

This study tests several new drug combinations given before and after surgery for stomach or esophageal cancer. About 100 people with resectable tumors will receive these treatments to see if they are safe and can shrink or eliminate the cancer. The goal is to improve outcomes by…

This early-stage trial is testing a new drug called IM-1617 in people with advanced solid tumors (cancers that have spread or can't be removed by surgery). The study has two parts: first, finding a safe dose, then testing that dose in more people to see how well it works and how …

This study follows 200 adults with achalasia who undergo a procedure called POEM (peroral endoscopic myotomy). The goal is to see if the procedure safely reduces chest pain and swallowing problems. Researchers will review past and future patient records up to 180 days after the p…

This study tests an experimental drug called YH32364 in adults with advanced solid tumors that have high levels of EGFR and have not responded to previous treatments. The trial has two parts: first, finding a safe dose in about 30 people, then testing that dose in 50 people with …

This study tests a new experimental drug called PLX-61639 for people with advanced solid tumors that have a specific genetic change (SMARCA4 mutation) and have stopped responding to standard treatments. The drug is taken as a daily pill and aims to shrink or control the cancer. A…

This study tests a drug called trastuzumab deruxtecan (T-DXd), alone or with chemotherapy and immunotherapy, in people with advanced HER2-positive stomach or esophageal cancer. The goal is to see if these combinations are safe and can shrink tumors. About 450 adults with cancer t…

This early-stage trial is testing an experimental drug called CHS-114 combined with the immunotherapy toripalimab, with or without standard chemotherapy, in 154 people with advanced or metastatic solid tumors. The main goal is to see if the combination is safe and to get an early…

This study is testing a new robotic system that uses just one small incision to perform surgeries on the liver, pancreas, stomach, and esophagus. The goal is to see if this single-port approach is safe and works well for these complex operations. The study will enroll 35 adults w…

This phase II trial is testing whether combining the immunotherapy drug adebrelimab with two chemotherapy drugs (nab-paclitaxel and carboplatin) before surgery can help patients with borderline resectable esophageal cancer. The goal is to increase the chance of completely removin…

This study tests a new experimental drug, PF-08634404, combined with chemotherapy in people with advanced stomach, gastroesophageal junction, or esophageal cancer that has not been treated before. The trial has two parts: first checking safety and response, then comparing the new…

This study compares two ways of placing a stent in the liver to prevent repeat bleeding from swollen veins in the throat or stomach in people with cirrhosis. The standard method fully expands the stent, while the new method uses a smaller balloon to keep it slightly narrower. The…

This phase 2 trial tests a drug called zanidatamab in about 200 adults with advanced HER2-positive cancers, including breast, lung, stomach, and others. Participants have already tried at least one standard treatment. The study measures how many tumors shrink or disappear. Zanida…

This study tests a shorter, more intense radiation schedule combined with chemotherapy for people with locally advanced esophageal cancer. The goal is to see if this approach is safe and feasible, and to reduce side effects like low white blood cell counts. About 60 adults will r…

This early-phase trial is testing a new drug called enzelkitug, alone or with standard immunotherapies, in people with advanced solid tumors that have not responded to other treatments. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. A…

This phase 2 trial is testing a combination of three drugs—adebrelimab, apatinib, and tegafur—in 32 people with advanced esophageal cancer that has not responded to first-line immunotherapy. The goal is to see if this new mix can shrink tumors or slow the disease. Participants wi…

This study tests whether giving two drugs (anlotinib and bemocizumab) before surgery can improve outcomes for people with resectable esophageal squamous cell carcinoma. About 25 adults with stage II-IIIB disease will receive the combination, then undergo surgery. The main goal is…

This early-phase study tests a new radioactive drug, LY4337713, in people with advanced cancers that have high levels of a protein called FAP. The cancers include certain types of ovarian, breast, pancreatic, colorectal, esophageal, stomach, and bile duct cancers. The study aims …

This study tests a new drug that delivers a tiny dose of radiation directly to cancer cells that have a specific marker called FAP. The trial involves 112 adults with advanced cancers of the pancreas, stomach, esophagus, colon, ovary, head/neck, sarcoma, or mesothelioma. First, a…

This program provides the experimental drug ulixertinib to people with advanced solid tumors that have certain gene mutations (MAPK pathway). It is for patients who have not responded well to or have run out of standard treatments. The goal is to control the disease and possibly …

This phase II trial is testing a combination of proton radiation and chemotherapy (carboplatin and paclitaxel) before surgery for patients with resectable esophageal or esophagogastric junction cancer. The goal is to see if this approach is safe, tolerable, and effective at impro…

This study tests a new medication, linaprazan glurate, to see if it heals esophagus damage from acid reflux better than a standard drug. About 500 adults with erosive esophagitis will take either the new drug or lansoprazole daily for up to 8 weeks. Doctors will use cameras to ch…

This study tests whether combining the immunotherapy drug camrelizumab with chemotherapy and radiation can shrink advanced esophageal cancer enough to avoid surgery. About 164 patients with stage II to IVa esophageal squamous cell carcinoma will receive one of two drug combinatio…

This early-stage trial tests a new treatment for advanced esophageal cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (CAR-NK cells) from donated cord blood that are designed to recognize and attack cancer cells carrying tw…

This study tests a new drug called ifinatamab deruxtecan in people with advanced solid tumors that have not been cured by other treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 250 participants will take part, and those who benefit may …

This early-stage trial is testing a new treatment called DISP-10 for people with advanced gastrointestinal cancers, including colorectal and stomach cancers. The treatment combines a virus (DV-10) with specially engineered immune cells (CAR T cells) to attack cancer. The study ai…

This study looks at two approaches for people with a type of esophageal cancer that shrank after initial chemo-immunotherapy. One group will have surgery to remove the tumor, while the other will get a combination of radiation and chemotherapy instead. Both groups will also recei…

This study looks at whether giving immunotherapy (adebrelimab) plus chemotherapy at different times of day changes how well it works for people with esophageal cancer. 90 participants will be split into three groups based on infusion timing before surgery. The main goal is to see…

This phase 2 study is testing whether adding two newer drugs—pembrolizumab (an immunotherapy) and trastuzumab (a targeted therapy)—to standard chemotherapy can help people with HER2-positive esophageal or stomach cancer that can be surgically removed. About 49 adults will receive…

This study tests a new drug called BC3195 combined with pembrolizumab (an immunotherapy) in people with advanced solid tumors that have spread. The goal is to find a safe dose and see if the combination can shrink tumors. About 111 adults with certain cancers will take part.

This phase 2 trial is testing an experimental drug called volrustomig, either alone or with chemotherapy, in people with advanced cervical, head and neck, esophageal, or mesothelioma cancers. The study aims to see if the drug can shrink tumors and how safe it is. About 257 partic…

This early-phase trial is testing a new drug called KK2260 in people with advanced solid tumors that have not responded to standard treatments. The study will first find the safest dose, then test different dosing schedules in patients with esophageal or head and neck cancers. Ab…

This study tests whether giving anti-viral medication to kill the shingles virus (VZV) living in the gut can improve symptoms of achalasia, a severe swallowing disorder. Researchers will enroll 40 adults with achalasia and measure changes in swallowing, pain, and weight. The goal…

This study tests a new antibody called HMBD-001 combined with two existing cancer drugs (cetuximab and docetaxel) in people with advanced squamous cell cancers of the lung, head and neck, esophagus, cervix, or skin. The goal is to see if the combination is safe and can shrink tum…

This study tests new experimental drugs combined with standard chemotherapy and immunotherapy for people with advanced stomach, gastroesophageal junction, or esophageal cancer that cannot be removed by surgery or has spread. About 160 participants will receive the combination to …

This study tests a new drug, TER-2013, in people with advanced solid tumors (like breast, ovarian, or lung cancer) that have specific genetic changes in the AKT/PI3K/PTEN pathway. The goal is to see if the drug is safe and can shrink tumors. About 205 participants will receive th…

This study tests a drug called tislelizumab in people aged 70 and older with advanced esophageal cancer who are not healthy enough for standard chemotherapy. The drug is given through an IV and aims to help patients live longer and with better quality of life. Researchers will tr…

This study tests whether adding the immunotherapy drug iparomlimab after standard chemoradiation can help older adults (70+) with inoperable esophageal cancer live longer without the disease getting worse. About 52 participants will receive the drug for one year after chemoradiat…

This study tests whether adding adalimumab to standard chemotherapy and radiation before surgery can help eliminate esophageal cancer more effectively. About 37 adults with resectable esophageal squamous cell carcinoma will receive this combination. The main goal is to see how ma…

This study looks at whether supervised exercise can improve recovery in people who have had surgery for esophageal or gastric cancer. About 171 participants will be assigned to high-intensity interval training, low-intensity continuous training, or usual care for 8 weeks. The goa…

This Phase 2 trial is testing a new drug called denikitug, alone or combined with other cancer drugs, in 120 people with advanced HER2-negative stomach, gastroesophageal junction, or esophageal cancer that has worsened after initial treatment. The main goal is to see if the drug …

This phase 2 trial tests a drug called HLX43 in 102 people with advanced esophageal cancer that did not respond to or could not tolerate standard first-line therapy. HLX43 is an antibody-drug conjugate designed to deliver a chemotherapy agent directly to cancer cells. The study a…

This study tests an experimental drug called LBL-024 combined with standard chemotherapy and immunotherapy for people with advanced solid tumors. About 110 adults with good overall health will receive the treatment to see if tumors shrink or stop growing. The goal is to find a sa…

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This study is testing a new experimental drug called GI-101, given alone or with pembrolizumab or lenvatinib, in people with advanced or metastatic solid tumors (cancers that have spread). The goal is to see if the drug is safe and can shrink or control tumors. About 317 adults w…

This phase 2 trial tests whether obeticholic acid can reduce damage from bile acids in people with Barrett's esophagus, a condition that can lead to esophageal cancer. About 30 adults with Barrett's esophagus will take the drug or a placebo for 6 months. Researchers will measure …

This Phase 2 trial tests whether adding the experimental drug givastomig to standard immunotherapy and chemotherapy can help people with advanced stomach or esophageal cancer live longer without their cancer growing. About 180 adults whose tumors have certain proteins (CLDN18.2 a…

This early-stage study is testing a new drug called ALX2004 in people with advanced lung, head and neck, esophageal, or colorectal cancers that have not responded to standard treatments. ALX2004 is an antibody-drug conjugate designed to deliver a cancer-killing payload directly t…

This study tests two new drug combinations for people with advanced stomach, gastroesophageal junction, or esophageal cancer that has worsened after initial treatment. About 210 participants will receive either an experimental antibody-drug conjugate plus chemotherapy, or a stand…

This phase 2 trial tests a new drug called vebrekotuzumab, which delivers a powerful toxin directly to cancer cells that have a protein called EGFR. It is being tested alone or with an immunotherapy drug in 104 patients whose esophageal cancer has stopped responding to initial tr…

This early-stage trial is testing a new drug called sigvotatug vedotin, alone or with other cancer medicines, in people with advanced solid tumors like lung, head and neck, and breast cancers. The study aims to find a safe dose and check for side effects. About 1,000 participants…

This study compares two methods of preventing bleeding during a procedure called POEM, used to treat swallowing disorders. The standard method uses carbon dioxide gas, while the new method uses water to help seal blood vessels. Researchers will enroll 120 adults to see if the wat…

This early-phase trial tests a new drug, UCB4594, in people with advanced solid tumors that haven't responded to standard treatments. The drug is a monoclonal antibody that targets a protein called HLA-G on cancer cells, potentially helping the immune system attack them. The stud…

This early-stage study is testing an experimental drug called MK-6204 in about 90 adults with advanced solid tumors (such as colorectal, lung, or stomach cancer) that have not responded to standard therapies. The main goals are to check the drug's safety and find the right dose. …

This clinical trial is looking at the best timing for local treatments like surgery or radiation in people with esophageal or stomach cancer that has spread to only a few spots. All participants first get 4 months of standard drug therapy. Then, depending on their response, they …

This study tests IKS014, a drug designed to seek out and destroy HER2-positive cancer cells, in people with advanced solid tumors like breast, stomach, and gastroesophageal cancers. The main goals are to find the safest dose and check for early signs of tumor shrinkage. About 165…

This early-phase study tests a new drug called VVD-130037 in people with advanced solid tumors that have stopped responding to standard treatments. The drug aims to activate a protein (KEAP1) to fight cancer. Researchers will check safety, side effects, and whether the drug works…

This phase II trial is testing whether adding a targeted radiation dose and the immunotherapy drug durvalumab to standard chemotherapy and radiation can help people with advanced esophageal cancer who have trouble swallowing. The study will enroll 54 adults whose cancer has sprea…

This pilot study looks at whether children with eosinophilic esophagitis (EoE) can safely eat heated forms of cow's milk and hen's egg without their disease coming back. Researchers will gradually introduce less heated versions to see if tolerance can be built. The trial involves…

This study tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part. This is an ear…

This study tests whether giving immunotherapy and chemotherapy before radiation works better than the standard chemoradiation for people with advanced esophageal cancer that cannot be removed by surgery. About 92 adults with stage III-IVA esophageal squamous cell carcinoma will b…

This study tests whether adding an immunotherapy drug (PD-1 inhibitor) to standard chemotherapy and radiation before surgery helps people with a certain type of esophageal cancer live longer. About 422 adults with stage T1-4aN1-3M0 or T3-4aN0M0 squamous cell esophageal cancer who…

This early-phase study tests a new drug called BL-M05D1 in people with advanced or metastatic solid tumors (like stomach, pancreatic, or bile duct cancer) that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see if the drug c…

This study tests if taking a budesonide tablet once daily works as well as taking it twice daily for adults with eosinophilic esophagitis, a condition where immune cells damage the esophagus. About 308 adults with active disease will receive one of the two dosing schedules for 6 …

This study tests a procedure called TIF (transoral incisionless fundoplication) for people with chronic acid reflux (GERD) who don't get relief from medication. It is done through the mouth, no cuts, and aims to rebuild the valve between the stomach and esophagus. The study will …

This early-phase trial is testing a new targeted drug called CA-4948 combined with standard chemotherapy and immunotherapy for people with advanced stomach, esophageal, or gastroesophageal junction cancer that cannot be removed by surgery. The study will enroll 42 participants an…

This study tests whether a newer acid-reducing drug, Vonaprazan, heals acid reflux better than the standard drug Esomeprazole in people who had POEM surgery for achalasia. About 300 adults with moderate to severe esophagitis will take one of the two drugs for 8 weeks. The goal is…

This Phase 2 trial tests whether adding the immunotherapy drug ivonescimab to standard chemotherapy can improve tumor shrinkage in people with advanced or metastatic stomach or gastroesophageal cancer. About 88 participants will receive treatment every two weeks. The main goal is…

This study tests a new drug called QLC5508 against standard chemotherapy in people with advanced esophageal cancer that has worsened after prior treatment. About 466 adults will be randomly assigned to receive either QLC5508 or a chemotherapy chosen by their doctor. The main goal…

This phase 2 study tests a new approach for people with advanced stomach, esophageal, or gastroesophageal junction cancer that is either PD-L1-negative or has stopped responding to immunotherapy. Participants receive injections of a cancer-killing virus (OBP-301) directly into th…

This early-stage study tests a new medicine called PF-08046033 in adults with advanced lung, esophageal, or skin cancers that have spread or can't be removed. The main goal is to check safety and find the right dose. Researchers will also look for early signs that the drug may he…

This study tests a combination of three drugs (JS212, JS001, and 5-FU) in 280 people with advanced esophageal squamous cell carcinoma that cannot be cured by surgery. The goal is to see if the combo is safe and can shrink tumors or slow the disease. Participants must not have had…

This phase 3 trial tests whether adding two drugs—toripalimab and capecitabine—after standard chemoradiation can prevent esophageal cancer from coming back. About 242 adults with advanced esophageal cancer who finished chemoradiation without progression will be enrolled. The goal…

This study tests whether a combination of tislelizumab (an immunotherapy) and chemotherapy can shrink advanced esophageal tumors enough to allow surgery. Thirty patients with initially inoperable cancer will receive 2-4 cycles of the drug combo, then be reassessed for surgery. Th…

This study is for people with stage I to III esophageal or gastroesophageal junction cancer. It tests whether giving a shorter, higher-dose radiation treatment along with chemotherapy (FOLFOX) before surgery can kill more cancer cells. The goal is to see if this approach leads to…

This early-stage study tests a new drug called PF-08046054/SGN-PDL1V, alone or with another drug (pembrolizumab), in people with advanced solid tumors like lung, head and neck, esophageal, breast, stomach, endometrial, pancreatic, or liver cancer. The main goals are to find safe …

This study tests whether adding immunotherapy (a drug that helps the immune system fight cancer) after standard chemotherapy and radiation can help people with advanced esophageal cancer live longer without the disease getting worse. About 452 adults with a specific type of esoph…

This Phase 1 trial is testing an oral drug called AUR107 in 50 adults with advanced solid tumors that have come back after prior treatment. The study aims to find a safe dose and understand how the drug moves through the body. It is the first time AUR107 is being tested in humans…

This study is for people with esophageal or stomach cancer that has spread to 3 or fewer places in the body. It compares standard chemotherapy alone to chemotherapy plus radiation or surgery to the main tumor and those spots. The goal is to see if adding local treatment helps peo…

This study looks at whether intensive nutritional support can help patients with advanced esophageal cancer who are receiving chemotherapy and immunotherapy before surgery. About 118 participants will be randomly assigned to either standard care or extra oral nutrition supplement…

This study is testing whether a dairy-free diet combined with a special liquid nutrition drink (Kate Farms formula) can help children with eosinophilic esophagitis (EoE) achieve remission. EoE is a condition where the esophagus becomes inflamed, often due to food allergies. The t…

This early-stage trial is testing a new drug called INCB123667, taken as a tablet, in people with advanced solid tumors that have not responded to standard treatments. The study will first test the drug alone, then in combination with other cancer therapies. The main goals are to…

This early-stage trial is testing a new drug called TGW101 in people with advanced solid tumors that have not responded to other treatments. TGW101 is given in two parts: an antibody-drug conjugate and a chemical trigger that activates it. The main goal is to check safety and fin…

This study tests a new drug (adebrelimab) combined with standard chemotherapy and radiation for people with advanced or returning esophageal cancer that cannot be removed by surgery. The goal is to see if this combination can shrink or control the cancer better. Thirty adults age…

This study tests whether adding the immunotherapy drug camrelizumab to a short course of chemotherapy and radiation can better control advanced esophageal cancer that cannot be removed by surgery. About 98 participants will receive one of two treatment schedules. The goal is to s…

This early-stage trial tests a new drug called KIVU-107 in 76 adults with advanced solid tumors that have not responded to standard treatments. KIVU-107 is an antibody-drug conjugate designed to target and kill cancer cells. The main goal is to find a safe dose and check for side…

This early-phase trial tests a new drug called NBTXR3, which is injected into the tumor and activated by radiation to destroy cancer cells. It is given alongside standard chemotherapy for people with stage II–III esophageal adenocarcinoma. The main goals are to find the safest do…

This study tests a modified version of sleeve gastrectomy, a common weight-loss surgery, to see if it can reduce or prevent acid reflux (GERD) that often occurs after the standard procedure. About 44 adults with obesity and GERD will be randomly assigned to receive either the sta…

This study tests whether adding the blood thinner apixaban to the heart drug carvedilol can prevent complications like bleeding, fluid buildup, and confusion in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable cirrhosis will take either api…

This early-phase study tests an experimental drug called PF-08046876 in about 310 adults with advanced cancers of the bladder, lung, head and neck, esophagus, or pancreas that have not responded to standard treatments. The drug is a type of 'antibody drug conjugate' designed to s…

This study compares two types of surgery for patients with early-stage stomach cancer near the esophagus. One method adds a procedure to widen the stomach outlet, which may help prevent severe acid reflux after surgery. The trial will track reflux, quality of life, and complicati…

This Phase 2 study tests a new drug, telisotuzumab adizutecan (ABBV-400), combined with standard chemotherapy and an immunotherapy drug for people with advanced stomach, gastroesophageal junction, or esophageal cancer that cannot be removed by surgery. About 180 adults will recei…

This early-phase study tests a new drug called 177LuBetaBart in people with advanced solid tumors that have stopped responding to standard treatments. The drug is a radioactive antibody designed to seek out and destroy cancer cells. The study will enroll about 61 participants and…

This study tests whether inflating a small balloon in the pylorus (the valve between stomach and small intestine) during minimally invasive esophageal cancer surgery can prevent delayed stomach emptying, a common complication. About 116 patients will be randomly assigned to recei…

This Phase 1 trial tests a new drug called BL-M07D1 in 280 adults with advanced HER2-positive cancers, including breast, lung, and stomach cancers. The study aims to find safe doses and check for early signs of tumor shrinkage. Participants must have tried at least two prior trea…

This study explores whether monitoring tumor DNA in the blood (ctDNA) can help guide treatment for esophageal cancer. Researchers will give patients immunotherapy and chemotherapy, followed by chemoradiotherapy, and track ctDNA levels to see if they predict outcomes. The goal is …

This study tests a new oral drug called KC1036 combined with standard immunotherapy (toripalimab) and chemotherapy (paclitaxel and cisplatin) as a first treatment for advanced esophageal cancer that has spread or come back. The trial will enroll 60 adults aged 18-75 who have not …

This study tests a newer, ultrasound-guided endoscopic technique to prevent repeat bleeding from enlarged veins in the stomach or esophagus of liver cancer patients. About 84 adults who recently had such bleeding controlled by standard endoscopy will be randomly assigned to recei…

This study tests a new injectable steroid called EP-104GI for adults with eosinophilic esophagitis, a condition where the esophagus becomes inflamed and makes swallowing difficult. The drug is given during an endoscopy and is designed to release medication slowly over time. The t…

This study tests a new implant designed to help regrow a damaged section of the esophagus in up to 10 adults. The implant uses a special scaffold combined with the patient's own stem cells. The goal is to see if it is safe and can create a new, living esophageal tube. Participant…

This phase 2 trial tests whether adding two newer drugs—serplulimab (an immunotherapy) and nimotuzumab (a targeted therapy)—to standard chemoradiation before surgery can improve outcomes for people with resectable esophageal cancer. About 46 participants will receive the combinat…

This study is testing whether a procedure called gastric preconditioning—done before esophageal cancer surgery—can lower the risk of a serious complication called an anastomotic leak. The procedure uses a tiny tube to redirect blood flow in the stomach, which may help the surgica…

This study tests a new drug called ivonescimab combined with standard chemotherapy (FOLFOX) in people with advanced HER2-negative stomach or esophagus cancer that has not been treated before. The goal is to see if the combination can keep the cancer from growing for at least 6 mo…

This early-stage study tests an experimental drug called TJ033721 (givastomig) in people with advanced or metastatic solid tumors that have stopped responding to standard treatments. The main goals are to check the drug's safety, find the right dose, and see how the body processe…

This study tests two different laser wavelengths (1470 nm and 1940 nm) for a procedure called laser crossectomy to treat varicose veins. The goal is to see which wavelength better prevents vein reflux from returning at the groin junction, while also checking for pain and side eff…

This early-phase study tests a new drug called STRO-004 in adults with advanced solid tumors that have not responded to standard treatments. The study has three parts: finding a safe dose of STRO-004 alone, testing that dose in more patients, and combining STRO-004 with another d…

This study compares two doses of vonaprazan (10 mg and 20 mg) with esomeprazole 40 mg for healing moderate to severe reflux esophagitis (grades B, C, or D) over 8 weeks. About 414 adults with GERD symptoms for at least 4 weeks will be randomly assigned to one of the three groups.…

This phase 2 trial is testing whether a combination of the immunotherapy drug bemosubaiabimab, the targeted pill anlotinib, plus radiation and chemotherapy can help people with oligometastatic esophageal cancer—cancer that has spread to a few spots. About 28 participants will rec…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This Phase 1 trial tests IDOV-Immune, a genetically engineered virus designed to infect and destroy cancer cells while boosting the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatme…

This Phase 2 trial is testing whether adding the immunotherapy drug tislelizumab to standard chemoradiotherapy can shrink advanced esophageal tumors enough to allow surgery. About 45 people with unresectable esophageal squamous cell carcinoma will receive the combination, followe…

This study is testing whether giving the immunotherapy drug adebrelimab along with standard chemotherapy before surgery can help people with locally advanced esophageal cancer. About 42 participants will receive the treatment every 3 weeks, then have surgery. The main goal is to …

This study tests a two-step approach for people with advanced esophageal cancer that cannot be removed by surgery. First, patients receive a combination of immunotherapy and chemotherapy. Then, based on how well the tumor responds, they get either the same drugs plus radiation or…

This study tests a new endoscopic procedure called anti-reflux mucosal ablation (ARAT) for people with chronic GERD. The procedure uses argon plasma coagulation to treat the lining of the stomach near the esophagus. 36 participants will be randomly assigned to receive either the …

This study is testing whether a chemotherapy pill (oral paclitaxel) combined with radiation can safely treat advanced esophageal cancer that cannot be removed by surgery. It is for people aged 70 or older, or those who cannot tolerate standard IV chemo. The goal is to control the…

This study tests whether a Botox injection into the stomach valve works as well as a surgical cut to prevent food from emptying too slowly after esophagus removal. About 170 adults having elective esophagectomy will be randomly assigned to one of the two procedures. Researchers w…

This study tests an experimental drug called AZD5863 in adults with advanced stomach, gastro-esophageal junction, pancreatic, or esophageal cancers that have spread. The drug is a bispecific antibody designed to bring immune cells close to cancer cells to attack them. The main go…

This study tests whether adding the drug adebrelimab to standard chemotherapy before surgery can help eliminate or shrink esophageal cancer more effectively. About 25 people with stage II/III esophageal squamous cell carcinoma will receive the combination, then have surgery. Rese…

This pilot study tests whether closing the diaphragm and securing the stomach tube during robotic esophageal cancer surgery can prevent a type of hernia that sometimes occurs afterward. Forty adults with esophageal cancer will be randomly assigned to either the standard approach …

This early-phase study tests a new cell therapy called GK01 in 10 people with advanced lung or esophageal cancer that no longer responds to standard treatments. The main goal is to check safety and how the body handles the therapy. Researchers will also look for early signs of tu…

This study tests a new treatment called EBNK-001, made from donor immune cells (natural killer cells), in people with advanced solid tumors that have not responded to standard therapies. Participants receive the cells after chemotherapy to prepare the body, along with low-dose in…

This early-phase trial is testing a new type of immunotherapy called CAR T-cells for people with a specific kind of stomach and esophageal cancer that has spread to the lining of the abdomen. The treatment involves collecting a patient's own immune cells, modifying them in a lab …

This early-phase trial is testing a new drug called NRM-823, alone or with immunotherapy, in people with advanced solid tumors like lung, ovarian, or breast cancer that haven't responded to standard treatments. The study aims to see if the drug is safe and tolerable. About 150 pa…

This study tests a new device called SpydrBlade Flex for a procedure that helps people with achalasia, a condition where the esophagus doesn't relax properly, making swallowing difficult. The device uses radiofrequency and microwave energy to cut muscle. Researchers will check if…

This study compares two strategies for preventing acid reflux after POEM surgery for achalasia: taking a PPI (Lansoprazole) every day for a year versus taking it only when reflux symptoms occur. About 132 participants will be randomly assigned to one of the two groups. The goal i…

This early-phase trial tests MGC026, a biologic drug given by IV, in 250 adults with advanced solid tumors that have not responded to standard treatments. The study has two parts: first, finding a safe dose, then expanding to see if the drug shrinks tumors. Participants receive u…

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to help the immune system attack cancer, followed by a…

This early-phase study tests a new drug called SH009 in people with advanced solid tumors (like liver, lung, breast, or stomach cancer) that have not responded to standard treatments. The main goals are to see if the drug shrinks tumors and to check its safety. About 150 adults w…

This Phase 3 trial tests whether adding fruquintinib to the standard drug trifluridine/tipiracil helps people with advanced stomach or gastro-esophageal cancer live longer. About 324 participants who have already tried at least two prior treatments will receive either the combo o…

This study tests whether surgically closing the hiatal opening can control gastroesophageal reflux disease (GERD) in people with early-stage disease. Researchers will enroll 40 adults aged 18-50 with a small hiatal defect and confirmed acid reflux. The main goal is to see if the …

This study tests a combination of an immunotherapy drug (ivonescimab) with two chemotherapy drugs before surgery for people with a certain type of advanced esophageal cancer. The goal is to see if this approach can shrink tumors enough to improve long-term outcomes. About 45 adul…

This study will follow 600 adults who are already scheduled to receive a standard procedure called POEM, which uses a scope to cut tight muscles in the throat or stomach. The goal is to see how well the procedure works over time for conditions like achalasia, gastroparesis, and Z…

This phase 3 trial is testing whether a personalized program of supplements (vitamin D, mushroom extract, fish oil, probiotics, and whey protein) plus lifestyle coaching can improve recovery and quality of life for people undergoing surgery for lung, stomach, or esophageal cancer…

This study tests a new drug called IMC-R117C, alone or with other cancer drugs, in people with advanced colorectal, esophageal, stomach, or ovarian cancers that have a specific genetic marker (HLA-A*02:01) and produce a protein called PIWIL1. The trial aims to find safe doses and…

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer or other solid tumors that have spread or cannot be removed. The main goals are to check the drug's safety, find the best dose, and see if it helps shrink tumors. About 470 adults will tak…

This study tests a new approach for people with locally advanced esophageal cancer. Participants first receive a combination of immunotherapy and chemotherapy, then chemoradiation, followed by surgery. The goal is to see if this sequence can shrink tumors more effectively and imp…

This early-stage trial tests the safety of a new drug called KK2269, given alone or with chemotherapy (docetaxel), in adults with advanced solid tumors that have no standard treatment options. About 101 participants will take part. The study has two parts: first testing KK2269 al…

This early-phase trial is testing a new drug, BC2027, in 180 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors or slow their growth. Participants re…

This early-phase study tests a new treatment called PTC13, which uses specially engineered immune cells (CAR-T cells) to attack cancer cells that have a protein called CEA. The study includes 18 adults with advanced colorectal, stomach, pancreatic, or other solid tumors that have…

This large phase 3 study is testing different combinations of chemotherapy, radiation, immunotherapy, and targeted drugs given before surgery for esophageal cancer. The goal is to find which approach works best to improve survival. The trial will enroll 2,000 adults with stage I …

This study is looking at the best way to treat esophageal cancer that cannot be removed by surgery. It will follow 2,000 patients who receive chemoradiotherapy (radiation plus chemotherapy) along with possible immunotherapy or targeted drugs. The goal is to see which combinations…

This early-phase study tests a new approach for people with a type of esophageal cancer. Participants receive standard chemotherapy followed by a special MRI-guided radiation treatment. The main goal is to find the safest radiation dose and see if this combination can better cont…

This early-phase trial tests whether giving an extra, higher dose of radiation guided by MRI can improve outcomes for people with a type of esophageal cancer. About 30 participants will receive standard chemoradiotherapy plus two extra radiation boosts. The main goal is to find t…

This study tests whether combining the targeted drug cabozantinib with immunotherapy drugs (durvalumab, with or without tremelimumab) is safe and effective for people with advanced stomach, esophageal, liver, or colorectal cancer. About 117 adults with stage 3 or 4 disease that c…

This study tests whether adding low-dose or standard radiotherapy to the usual combination of immunotherapy (anti-PD-1) and chemotherapy can help people with metastatic esophageal squamous cell carcinoma. About 100 adults who have not had prior treatment will participate. The goa…

This Phase 1 trial tests TQB6411, an antibody-drug conjugate designed to bind to EGFR and c-Met proteins on tumor cells, blocking their growth signals and releasing a toxin to kill the cells. The study will enroll 216 adults with advanced malignant tumors to find the safest dose …

This study tests a new drug called ifinatamab deruxtecan (I-DXd) in people with advanced esophageal cancer that has worsened after standard treatments like platinum chemotherapy and immunotherapy. About 510 adults will be randomly assigned to receive either I-DXd or a standard ch…

This Phase 1 trial is testing TJ101, an experimental antibody-drug conjugate that delivers chemotherapy directly to cancer cells. It is for adults with advanced or metastatic solid tumors (lung, prostate, esophageal, and others) who have run out of standard options. The study aim…

This study tests a new drug called JAB-8263 in adults with advanced solid tumors or blood cancers that have stopped responding to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. About 152 people will take part in this early-phase trial.

This study tests whether giving chemotherapy plus immunotherapy before treatment can shrink esophageal tumors enough to remove them with an endoscope (a thin tube down the throat) instead of major surgery. About 60 adults with early-stage esophageal cancer will receive two or mor…

This early-stage trial is testing a new drug called IPH4502 in people with advanced solid tumors that have a specific protein called Nectin-4. The main goals are to check the drug's safety and find the best dose. About 145 participants will receive the drug, and researchers will …

This study tests whether adding immunotherapy to a precise type of radiotherapy (sparing tumor-draining lymph nodes) and chemotherapy can help adults with advanced esophageal cancer live longer without the disease getting worse. About 432 participants will receive either the comb…

This phase II trial is testing a rotating schedule of two chemotherapy regimens (FOLFOX and FOLFIRI), with or without the immunotherapy nivolumab, in 38 people with advanced HER2-negative gastric or esophageal cancer. The goal is to see if this approach improves tumor shrinkage a…

This study tests a new tablet called ABP1011T in people with advanced solid tumors, including small cell lung cancer and others like esophageal or bladder cancer. Participants take one pill daily in 21-day cycles. The goal is to see if the drug can shrink tumors and how safe it i…

This study tests adding propranolol, a blood pressure medicine, to standard chemoradiation for people with esophageal adenocarcinoma. About 106 participants will receive the combination to see if it is safe and helps control the disease longer. The goal is to improve treatment wi…

This study looks at a two-part procedure to prevent repeat bleeding in people with cavernous transformation of the portal vein, a rare condition where the main vein to the liver is blocked. The procedure involves blocking the bleeding veins and partially blocking the splenic arte…

This study tests whether adding the drug cadonilimab to standard chemotherapy before and after surgery helps people with a certain type of esophageal cancer. About 90 adults with resectable, locally advanced cancer will take part. The goal is to see if the combination leads to mo…

This study tests whether vonoprazan, a stomach acid blocker, can prevent ulcers that often form after endoscopic variceal band ligation (EVBL) in people with liver cirrhosis. About 154 adults will take either vonoprazan or a placebo daily for 14 days after the procedure. Research…

This study tests whether giving two different chemotherapy regimens one after the other before surgery can help people with esophageal cancer that has spread to nearby lymph nodes. About 216 adults with resectable cancer will receive either FLOT followed by CROSS or CROSS followe…

This early-phase trial tests an oncolytic virus (IDOV-SAFE) in about 89 people with advanced digestive cancers, like colorectal or stomach cancer, that have not responded to standard treatments. The virus is designed to infect and kill cancer cells. Some participants may also rec…

This early-phase trial tests a new combination of the immunotherapy drug tislelizumab plus standard chemotherapy (FLOT) given before surgery for people with stomach, esophageal, or gastroesophageal junction cancer that can be removed. The goal is to see if this longer pre-surgery…

This early-stage study tests whether combining two drugs (sacituzumab govitecan and capecitabine) is safe for people with advanced gastrointestinal cancers that have stopped responding to standard treatments. About 20 adults with stomach, colorectal, or pancreatic cancer will tak…

This study tests a special stent called LIVERTY TIPS, placed in the liver to create a new pathway for blood flow in people with cirrhosis and high blood pressure in the liver. The goal is to see if it can keep the new channel open and reduce problems like bleeding or fluid buildu…

This study tests a drug called Zemaira in 15 adults with eosinophilic esophagitis, a condition where white blood cells build up in the esophagus, causing pain and trouble swallowing. Participants receive Zemaira infusions for 4 weeks to see if it reduces inflammation and improves…

This study tests whether two immunotherapy drugs (iparomlimab and tuvonralimab) plus chemotherapy can help people with advanced esophageal cancer that has come back or spread. About 25 adults will receive the treatment for up to 24 months. The goal is to see if the combination sh…

This study tests a new device (Intrepid TMVR) to replace the mitral valve in people with severe mitral regurgitation (leaky heart valve) who are not candidates for standard surgery or repair. About 400 participants will receive the device and be followed for safety and effectiven…

This phase 2 trial is testing whether adding propranolol, a common beta-blocker used for heart conditions, to standard chemotherapy and pembrolizumab (an immunotherapy) can improve treatment response in people with advanced esophageal or gastroesophageal junction cancer that cann…

This study tests whether adding omega-3 fatty acids (EPA and DHA) to standard PD-1 inhibitor therapy helps patients with advanced esophageal cancer. About 142 adults will receive either omega-3 or placebo drops daily for 6 months alongside their cancer treatment. The main goal is…

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with another cancer drug (pembrolizumab). It is for adults with advanced solid tumors or lymphoma that have not responded to or are no longer controlled by available treatments. The goal is to …

This early-phase trial tests a new drug called MT-4561 in about 27 people with advanced solid tumors (like lung, breast, or pancreatic cancer) who have no standard options left. The main goals are to find a safe dose and see if the drug can shrink tumors. It is a first-in-human s…

This study tests whether injecting a cancer-killing virus directly into tumors, combined with standard chemotherapy and an immunotherapy drug, can shrink advanced esophageal cancer enough to allow surgery. About 40 adults with unresectable locally advanced esophageal squamous cel…

This study tests whether the drug adebrelizumab can help prevent esophageal cancer from returning after surgery. About 142 adults who had their cancer completely removed will receive either adebrelizumab or a placebo. The main goal is to see how long patients stay cancer-free, an…

This study tests a new drug called envafolimab combined with standard chemotherapy given before surgery for people with a type of esophageal cancer that can be removed. The goal is to see if this combination can shrink the tumor more effectively, potentially leading to better lon…

This study tests a combination of two drugs, afatinib and palbociclib, in people with advanced esophageal cancer that has come back or spread after prior treatment. The goal is to find a safe dose and see if the combo can shrink tumors. About 45 adults aged 18 to 75 with a specif…

This study tests whether combining the immunotherapy adbelimumab with chemotherapy and the targeted drug apatinib can help shrink esophageal tumors before surgery. About 35 adults with resectable esophageal squamous cell carcinoma will receive four cycles of the drug combo, then …

This study is testing the drug dupilumab in 20 children whose eosinophilic gastrointestinal disorders have not responded to other treatments. The goal is to see if dupilumab can heal ulcers and reduce inflammation in the stomach and gut. Children receive injections every one or t…

This study tests whether a simple esophageal string test (EST) can diagnose eosinophilic esophagitis (EoE) in people who have trouble swallowing. Participants swallow a capsule with a nylon string that collects fluid from the esophagus, which is then analyzed. The results will be…

This trial compares two ways to sample tissue in people with Barrett's esophagus, a condition that raises the risk of esophageal cancer. The standard method takes four small tissue samples every 2 centimeters, while the newer method uses a brush to collect cells over a wider area…

This study is testing whether a new blood test can screen for many types of cancer at once. Researchers will enroll 24,000 adults aged 45-75 who do not have cancer. Participants will be randomly assigned to one of two blood test groups or a control group. The goal is to see how w…

This study is testing a new type of PET/CT scan called [¹⁸F]FAPI-74 to see if it can better detect when stomach or esophageal cancer has spread to other parts of the body. About 200 adults with these cancers will receive one dose of the scan tracer and be followed for up to 3 mon…

This study is testing a blood test that looks for tiny bits of cancer DNA (ctDNA) in people with esophageal, gastric, or pancreatic cancer. The goal is to see if it can find signs of cancer coming back or getting worse earlier than current methods. About 34 participants will give…

This study tests a dye called CYTALUX (pafolacianine) that attaches to cancer cells and glows under a special camera during surgery. About 50 adults with certain cancers (like esophageal, pancreatic, or gynecologic) will get the dye before surgery. The goal is to see if the glowi…

This trial is testing a new, less invasive way to detect Barrett's esophagus, a condition that can lead to esophageal cancer. Participants swallow a capsule attached to a string that expands into a sponge in the stomach, collecting cells as it is pulled back up. The goal is to se…

This early-phase study tests whether a special PET scan using a radioactive tracer called 18F-AraG can find tumors in people with esophageal cancer and predict how well they respond to chemoradiation. About 60 adults with untreated, locally advanced esophageal cancer will receive…

This study looks at whether taking multiple saliva samples over time can better detect Barrett's esophagus, a condition where the lining of the food pipe changes and can raise the risk of cancer. About 275 adults who have had or will have an endoscopy will provide saliva samples.…

This early-phase study tests a radioactive tracer called [68Ga]Ga-ABY-025 for PET scans in 30 adults with advanced HER2-positive cancers (breast, gastric, head/neck, esophageal). Participants receive the tracer and a PET/CT scan before or during standard HER2-targeted therapy. Th…

This study is testing a new, non-invasive way to detect high-risk varices (enlarged veins) in the esophagus and stomach of people with liver cirrhosis. Instead of using a camera down the throat (endoscopy), doctors will use a special ultrasound technique called SHAPE, along with …

This early-stage trial tests a radioactive imaging agent called RAD301 in 9 people: healthy volunteers and patients with pancreatic, lung, esophageal, cervical, endometrial, or ovarian cancer. The goal is to see how safe it is and how it travels through the body. If it works, it …

This study tests a new way to find early signs of esophageal cancer in people with Barrett's esophagus. Participants will receive two fluorescent dyes (bevacizumab-800CW and cetuximab-800CW) either by mouth or directly on the esophagus before a standard endoscopy. The goal is to …

This study tests a wearable device called the C-mo System that automatically detects and describes coughs. Researchers want to see if it can accurately count coughs, measure their intensity, and identify wheezing. 300 people aged 2 and older with cough-related conditions will wea…

This study is testing whether a new type of MRI (4D flow MRI) can detect dangerous veins in the stomach and esophagus of people with cirrhosis, which can cause fatal bleeding. Currently, doctors use a camera down the throat (endoscopy) to check, but that is invasive and often unn…

This study tests a new, less invasive way to look for Barrett's esophagus, a condition that can lead to cancer. Instead of a traditional endoscopy, a capsule attached to a string is swallowed to take pictures of the esophagus. The goal is to see if this method works well for dete…

This study explores whether a magnetic resonance spectroscopy (MRS) scan of the thigh can predict a patient's fitness for major cancer surgery, as an alternative to the standard cardiopulmonary exercise test (CPET). Researchers will compare fat levels in thigh muscles from the MR…

This study looks at whether the things people buy at stores—like pain relievers or digestive aids—could be early warning signs of cancer. Researchers will compare the shopping habits of 2900 people, some diagnosed with cancer and some not, to see if certain purchases happen more …

This study tests a simple, non-invasive device called EndoSign, which is a sponge on a string that you swallow in a capsule. The sponge collects cells from the esophagus, which are then tested for signs of Barrett's esophagus, a condition that can lead to cancer. The results will…

This study tests how well PET/CT scans, along with other imaging, can define the exact edges of esophageal cancer before and after treatment. Researchers will compare these images to the actual tumor removed during surgery. The goal is to improve surgical planning and ensure all …

This study tests whether artificial intelligence (AI) can analyze routine heart tests (ECGs) to find hidden heart problems like weak heart muscle, valve issues, or high lung pressure. About 590 adults without a prior heart disease diagnosis will have ECGs taken with standard mach…

This study tests a portable microscope with artificial intelligence to help doctors spot early signs of esophageal cancer during a routine scope exam. Researchers will enroll 200 adults in Brazil and the United States who are already scheduled for screening. The goal is to see if…

This study aims to see if certain chemicals (oncometabolites) in a person's breath and blood can spot early-stage gastro-esophageal cancer. Researchers will compare samples from 1,000 people, including those with cancer, those with Barrett's esophagus (a precancerous condition), …

This study is testing a new, less invasive way to diagnose Barrett's esophagus and esophageal cancer using a sponge capsule that patients swallow. The sponge collects cells from the esophagus, which are then analyzed for signs of disease. Researchers will enroll 1,550 people aged…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before it shows up on scans. The …

This study tests a special dye and imaging system to help surgeons see colorectal, pancreatic, esophageal, and stomach cancers during surgery. About 66 adults scheduled for cancer surgery will receive the dye, and the imaging system will check if it lights up cancer tissue. The g…

This study is testing a new type of PET scan that uses special probes to highlight digestive system cancers, such as stomach, liver, colon, and pancreatic cancers. Researchers will enroll 400 adults to see how well this imaging method finds tumors and tracks their response to tre…

This study tests a new PET imaging probe that targets a protein called CLDN18.2, found in some stomach, pancreatic, bile duct, and esophageal cancers. Researchers will scan 56 people (patients and healthy volunteers) to see if the scan can accurately detect tumors and guide treat…

This study is testing a simple, less invasive way to detect early signs of Barrett's esophagus, esophageal cancer, and stomach cancer. Participants swallow a capsule attached to a string, which expands into a sponge in the stomach to collect cell samples. Researchers then look fo…

The SYNERGY study is developing a blood test that looks for tiny genetic molecules called microRNAs to detect esophageal squamous cell carcinoma (ESCC) at an early, more treatable stage. Researchers will collect blood samples from 600 adults with and without ESCC to build and val…

This study is developing a blood test that looks for tiny genetic molecules called miRNAs, which can signal the presence of several gastrointestinal cancers like liver, pancreatic, and colorectal cancer. Researchers will analyze blood samples from 1,000 adults—half with cancer an…

This study tests whether using a special formula (MCT) for tube feeding right after esophageal cancer surgery can prevent chyle leak, a complication where lymph fluid leaks into the chest. About 160 adults having minimally invasive surgery for esophageal cancer will be randomly a…

This study tests whether giving the drug amiodarone after minimally invasive esophageal cancer surgery can prevent a common complication called atrial fibrillation (an irregular, often rapid heart rhythm). About 90 adults having this surgery will be randomly assigned to receive e…

This study is testing a web-based tool that estimates a person's risk of developing Crohn's disease based on their lifestyle and family history. Researchers will enroll 80 healthy people who have a parent or sibling with inflammatory bowel disease. Participants will receive perso…

This study tests whether a special algorithm called PAGODA can reduce unplanned delays during FOLFOX chemotherapy for gastrointestinal cancers like colon, stomach, and esophageal cancer. About 420 participants will be randomly assigned to either standard care or the algorithm-gui…

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This study tests whether a program of physical therapy, nutritional planning, and psychological support before and after surgery can help patients with locally advanced esophageal, gastroesophageal junction, or stomach cancer recover better. Sixty participants will follow the pro…

This study tests a device called eGERD that sends mild electrical pulses to the belly to reduce acid reflux and symptoms like heartburn. 84 adults with GERD will use either the real device or a sham version at home for several weeks. Researchers will measure acid levels in the th…

This study looks at how safe and effective a new device, the Speedboat UltraSlim™, is when used for a surgery called POEM in people with achalasia or other throat muscle problems. The surgery is already standard care, and researchers will track symptom improvement and any side ef…

This study tests a symptom management program for 300 esophageal cancer patients after surgery. The program uses patient feedback to guide care and aims to reduce common problems like reflux, trouble swallowing, and eating difficulties. Participants use a smartphone app to report…

This study tests whether taking omega-3 fish oil capsules and doing simple resistance exercises with elastic bands can help cancer patients maintain muscle mass and strength. It involves 288 adults with various cancers who are at risk of muscle wasting. The goal is to improve phy…

This early-stage trial tests a new drug called GB18 in 18-36 cancer patients who are losing weight and appetite due to their illness (cachexia). The drug is given as a shot under the skin. The main goal is to check safety, but researchers will also see if it helps patients gain w…

This study compares giving the cancer drug nivolumab (Opdivo) as a shot at home versus in a clinic for people with various advanced cancers. The goal is to see if home treatment improves patients' overall care experience and quality of life. About 50 adults will receive the drug …

This study tests whether a combination of two drugs, fosrolapitant and palonosetron, plus a steroid, can prevent nausea and vomiting caused by chemotherapy and immunotherapy in people with esophageal or lung cancer. About 120 participants will receive the drug before each chemo c…

This study compares intravenous famotidine (a stomach acid reducer) and oral antacids (like Maalox) for treating dyspepsia (stomach pain) in the emergency department. About 80 adults with upper abdominal pain will rate their pain every 15 minutes for an hour. The goal is to see w…

This study tests whether a program of exercise and nutrition supplements before esophageal cancer surgery is practical and helpful. About 20 adults scheduled for surgery will either receive the program or standard care. Researchers will track how many people stick with the progra…

This study tests whether a probiotic supplement can improve gut health and reduce symptoms in people with reflux disease (GERD) who are already taking standard medication. Fifty participants will take either the probiotic or a placebo for six weeks. Researchers will check changes…

This study compares a shorter muscle cut (4-5 cm) during a procedure called POEM to the standard longer cut (8-10 cm) for people with certain swallowing disorders. The goal is to see if the shorter cut works just as well at relieving symptoms like trouble swallowing and chest pai…

This study looks at whether a simple exercise program is practical and helpful for people with non-small cell lung cancer who are getting radiation therapy, along with their family caregivers. About 40 pairs (patient and caregiver) will take part. The goal is to see if exercising…

This pilot study tests whether brodalumab, a drug used for autoimmune conditions like psoriasis, can safely reduce immune-related side effects caused by cancer immunotherapy. About 11 adults with advanced solid tumors who developed these side effects will receive brodalumab injec…

This study tests a personalized rehabilitation program for people recovering from surgery for esophageal or gastric cancer. Participants will receive a structured assessment of their physical, psychological, and social needs, followed by evidence-based support. The goal is to imp…

This study tests whether a daily probiotic supplement called BioAmicus Complete can help infants with colic, constipation, diarrhea, and eczema. 140 babies will receive either the probiotic drops or a placebo (sunflower oil) for 25 days. Researchers will track changes in stool, c…

This observational study in Germany looks at whether hydrotalcite (Talcid) can ease acid-related symptoms like heartburn that occur when people stop long-term use of proton pump inhibitors (PPIs). About 167 adults who recently stopped PPIs will take hydrotalcite as needed for fou…

This study tests a new infant formula designed to reduce how often babies spit up. About 346 healthy, full-term infants who spit up at least 4 times a day will receive either the new formula or a standard one. Researchers will track changes in spit-up frequency and severity over …

This study tests whether using CPAP or BiPAP breathing machines can reduce tumor movement during radiation therapy for lung cancer, esophageal cancer, or lymphoma. About 31 adults with advanced but treatable cancers will try these machines during treatment. The goal is to see if …

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen) can prevent low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. About 600 adults with a STOP-Bang score of 5 or higher will b…

This study looks at children born with esophageal atresia who develop narrowing (strictures) after surgery. Doctors use a balloon to stretch the narrowed area, but it's unclear how long the balloon should stay inflated. The trial will compare 30 seconds versus 180 seconds of infl…

This trial tests whether two types of breathing exercises can improve symptoms and quality of life in people with GERD. 42 adults will be randomly assigned to diaphragmatic breathing, incentive spirometry, or standard care for 6 weeks. Researchers will measure acid exposure, esop…

This study tests whether a yoga program designed for both patients and their family caregivers can improve physical function, fatigue, sleep, mood, and quality of life. It includes 400 people with lung or esophageal cancer who are getting radiation therapy, plus their caregivers.…

This study looks at whether people with certain cancers prefer getting their immune therapy as a shot under the skin (subcutaneous) or through a needle in a vein (intravenous). About 880 adults who are already eligible for standard treatments like nivolumab or pembrolizumab will …

This study tests whether domperidone, a drug that helps the stomach empty food, can reduce symptoms like pain, bloating, nausea, and vomiting in people with chronic digestive disorders. About 200 patients who have not improved with standard treatments will take domperidone and re…

This study tests whether Afluxin®, a natural gel made from tamarind seed, pea protein, and polyacrylic acid, can reduce heartburn and regurgitation in people with mild-to-moderate GERD. About 208 adults will take the gel or an inactive placebo three times daily for 7 days. The go…

This phase 3 trial tests whether a daily nutritional drink (Oral Impact®) can reduce severe throat and esophagus inflammation caused by chest radiation in lung cancer patients. About 121 adults with lung cancer who need radiation will drink two bottles a day during and for three …

This program gives domperidone to teenagers aged 12 to 21 who have severe stomach or reflux problems that haven't gotten better with standard treatments. The goal is to see if the drug can reduce their symptoms. Up to 20 participants will be enrolled.

This study tests a new device called the Speedboat™ Ultraslim, a bipolar radiofrequency knife, for removing precancerous growths in the esophagus. Researchers want to see if it works well and is safe compared to standard tools. The trial will involve 50 adults at two medical cent…

This study tests whether wearing virtual reality goggles during a colonoscopy or upper endoscopy can help patients need less sedation. Ten adults aged 21 to 65 will receive minimal sedation and wear a VR headset during the procedure. Researchers will measure how much sedative is …

This study tests a program of exercise, protein drinks, and mind-body activities like yoga for people aged 65 and older with advanced ovarian or pancreatic cancer. The goal is to see if patients can stick with the program while on chemotherapy before surgery. The study is small, …

This study tests whether a new device that combines a bite block, oxygen tube, and airway support can prevent dangerously low oxygen levels in severely obese patients during sedated endoscopy. About 410 adults with a BMI of 35 or higher will be randomly assigned to receive either…

This study tests an external band worn around the neck (Shaker Pressure Band) to see if it reduces nighttime symptoms of gastroesophageal reflux disease (GERD), such as coughing, choking, and regurgitation. Researchers will enroll 350 adults with GERD and track changes in their s…

This study tests whether using virtual reality (VR) can reduce severe belly pain and improve quality of life in people with digestive tract cancers. 360 participants will be split into three groups: one using a skills-based VR program, one using distracting VR videos, and a contr…

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

This study tests a six-week program of morning bright light exposure combined with moderate walking for people with lung or esophageal cancer. The goal is to see if it can improve sleep-wake rhythms, reduce physical and emotional symptoms, and boost quality of life. Two hundred p…

This study tests whether a probiotic called BioAmicus Complete can improve common stomach issues like colic, reflux, constipation, and diarrhea in infants up to 24 months old. About 110 babies will take the probiotic or receive standard care for 42 days. Parents will report sympt…

This study tests whether two common antidepressants, duloxetine and amitriptyline, can reduce coughing in people with refractory chronic cough—a cough that persists despite standard treatments. About 50 adults will receive either a low or high dose of one drug or a placebo for 4 …

This study tests whether olanzapine, a drug already used for other conditions, can help cancer patients who are losing weight and appetite. About 66 adults with advanced lung, stomach, or bowel cancers will receive either olanzapine or a placebo. The goal is to see if olanzapine …

This study tests whether a personalized comfort care plan can help people with advanced esophageal cancer live longer and feel better. About 624 adults whose cancer has spread or returned will receive either standard comfort care or a tailored version that adjusts to their needs.…

This study is testing whether a mobile app that guides users through yoga poses is practical and safe for people with lung cancer who are getting radiation therapy, and for their family caregivers. About 60 patient-caregiver pairs will try the app at home. The goal is to see if p…

This study tests whether fecal microbiota transplantation (FMT) – taking donor gut bacteria in capsules – can prevent or reduce gastrointestinal symptoms like nausea, vomiting, and diarrhea caused by chemotherapy or targeted therapy. It involves 90 adults with advanced (Stage IV)…

This study looks at whether problems with how the stomach and esophagus move increase the risk of aspiration (food or liquid going into the lungs) in children with brain-related disabilities. It compares two drugs, prucalopride and famotidine, to see which better reduces symptoms…

This study tests whether a newer drug, zastaprazan, can relieve nighttime heartburn better than the standard drug esomeprazole in people with erosive GERD. About 160 Korean adults with nighttime heartburn for over 3 months will take one of the two drugs and report their sleep qua…

This phase 2 trial is testing whether adding two chemotherapy drugs (carboplatin and paclitaxel) to standard palliative radiation can better relieve difficulty swallowing in people with incurable esophageal cancer. The study enrolls 50 patients who have trouble swallowing solid f…

This study compares two versions of a procedure called POEM for people with achalasia, a condition where the esophagus doesn't relax properly, making swallowing difficult. About 52 adults with type I or II achalasia will be randomly assigned to receive either the standard circula…

This study looks at whether a short exercise program before surgery is practical and helpful for people with esophageal cancer. About 20 patients will take part. The goal is to see if patients can stick with the program and if it improves their recovery.

This study aims to collect tumor, normal tissue, and blood samples from up to 1559 people with cancers of the lung, esophagus, or pleura. Researchers will analyze genetic and epigenetic changes to better understand these diseases and identify potential markers for future treatmen…

This study looks at whether giving the chemotherapy drug paclitaxel over a longer period (2-3 hours instead of 1 hour) can help cancer patients with low muscle mass achieve safer drug levels. Researchers will compare drug concentrations in 22 women with breast, stomach, or esopha…

This study looks at the causes and effects of food allergies and related conditions like eczema and eosinophilic esophagitis. Researchers will collect blood, skin, and genetic samples from up to 1,800 people over many years. The goal is to find biomarkers and pathways that explai…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study follows 200 adults and children with eosinophilic esophagitis (EoE) in Italy to learn how the disease progresses over time and how well current treatments work. EoE is an allergic condition that causes swallowing problems and can lead to scarring if not treated. The re…

This study watches for heart changes in 150 adults receiving chest radiation for lung, esophageal, breast, or thymus cancer. Researchers will check heart markers, electrical activity, and immune cells at the end of treatment and up to 3 months later. The goal is to find early sig…

This study is a registry that collects information from 1,000 people with symptomatic mitral valve disease, including mitral regurgitation and stenosis. The goal is to better understand how correcting these heart valve problems with a less invasive procedure called transcatheter …

This Phase 1 trial is testing a new drug called linaprazan glurate in 121 healthy adults to see how the body absorbs and processes it, and whether it affects heart rhythm. The study is double-blind and placebo-controlled, meaning some participants get a dummy pill. It is an early…

This study is testing how to safely perform skin allergy tests in people receiving biotherapies for cancers and blood disorders. Researchers will find the highest concentration of each biotherapy that does not cause a skin reaction in 9 out of 10 patients. The goal is to establis…

This study watches how people with eosinophilic esophagitis (EoE) use the medicine Dupixent in everyday care. Researchers will collect information from about 350 patients to learn more about the disease and how treatment affects symptoms and quality of life. No new treatments are…

This study collects small tissue samples from the stomach and upper intestine of people with severe gastroparesis (delayed stomach emptying). Researchers look for specific cell abnormalities that might predict whether a patient will benefit from a gastric electrical stimulation d…

This study looked at whether low oxygen levels after esophageal cancer surgery increase the chance of a leak where the esophagus is reconnected. Researchers reviewed records of 2,083 patients, comparing those with low oxygen to those with normal levels. The goal was to see if cor…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study investigates whether the unique bacteria found inside digestive system tumors can help predict how well a patient will respond to neoadjuvant therapy (chemotherapy before surgery). Researchers will analyze tumor samples from 90 adults with pancreatic, gastric, colorect…

This study compares two techniques—esophageal manometry and EndoFLIP balloon measurements—to evaluate how well they assess swallowing difficulties (dysphagia). Researchers will enroll up to 1,000 patients with known esophageal conditions to see how these measurements relate to sy…

This study looks at a newly identified condition called FIRE (Food Induced Immediate Response of the Esophagus) in children with eosinophilic esophagitis. Researchers want to find out how common FIRE is and describe its symptoms, like chest pain or choking within minutes of eatin…

This study is creating a registry of up to 5,000 patients with various gut movement disorders, such as GERD, gastroparesis, and IBS. Doctors will use standard criteria to make accurate diagnoses and collect patient-reported outcomes. The goal is to improve understanding of these …

This study is collecting information on side effects from proton therapy in 5,000 adults with many types of cancer. Researchers will track both short-term and long-term side effects and link them to the details of each patient's treatment plan. The goal is to better predict who m…

This study looks at whether giving proton pump inhibitors (like omeprazole) to people with cirrhosis who have bleeding in the esophagus causes more complications in the hospital. Researchers will randomly assign 60 adults to receive either the drug or no drug after an endoscopic …

This study looks at how the body absorbs esomeprazole (a stomach acid reducer) when taken as a tablet or dissolved in water, in people who had gastric bypass surgery a year ago. Fifty participants will have a small device placed in their stomach pouch to measure acid levels, and …

This study looks at whether weak esophageal contractions (ineffective motility) improve after partial fundoplication surgery for gastroesophageal reflux. Researchers will perform high-resolution manometry 18-24 months after surgery in 100 patients who had weak contractions before…

This study observes children with eosinophilic esophagitis (EoE) to understand how their symptoms, endoscopy findings, and inflammatory markers change over time during standard care. Researchers will collect data from up to 1,500 participants during routine clinic and endoscopy v…

This study looks at 200 adults to compare acid reflux-related damage in two groups: people who had a procedure called POEM for achalasia (a swallowing disorder) and people without any swallowing problems. Researchers will use endoscopy and acid monitoring to see if the pattern of…

This study is looking at whether a blood test (liquid biopsy) can find tiny bits of cancer DNA left behind after treatment for esophageal cancer. Researchers will collect blood samples from 248 patients before, during, and after standard treatment. The goal is to see if this test…

This study is for Black adults newly diagnosed with gastrointestinal cancer. It focuses on ensuring patients receive proper biomarker testing and evidence-based care, helping them find and join clinical trials if they choose, and providing easy-to-understand information about the…

This study is creating a database to track how people with esophageal or gastroesophageal junction cancer that has spread to only a few places (like the liver or lymph nodes) are treated in real-world settings. Researchers will collect information from 50 participants to see whic…

This study observes how doctors decide the length of the muscle cut during POEM surgery for people with swallowing disorders like achalasia. Researchers will follow 200 adults for 2 years, tracking symptoms and whether retreatment is needed. The goal is to see if tailoring the su…

This study looks at people with a rare and aggressive type of esophageal cancer that hasn't spread. It compares those who had surgery (with or without other treatments) to those who had non-surgical treatments like chemotherapy and radiation. The goal is to see which approach hel…

This early-stage trial tests whether a special PET scan (FMISO-PET) can identify oxygen-deprived (hypoxic) areas in esophageal tumors, which are harder to treat. Patients with hypoxic tumors receive a higher radiation dose, while others get standard care. The study aims to see if…

This study looks at how radiation treatment for esophageal cancer affects the body's ability to respond to the pneumonia vaccine. Researchers will give the vaccine to 80 patients who have low white blood cell counts after chemoradiation. They want to see if the vaccine still work…

This study looks at people with high blood pressure in the liver that causes swollen veins in the esophagus and stomach. Researchers will compare those who get an endoscopic procedure (using a camera down the throat) with those who receive other treatments like medicine or surger…

This study is building a large database of 15,000 patients with esophageal or gastric cancers in France. Researchers will look back at medical records to see how patients fared after surgery, focusing on how long they stayed cancer-free. The goal is to learn more about survival, …

This study is checking if chest X-rays can reliably find lung, heart, and esophagus problems in 300,000 adults during routine check-ups. People getting a health exam will have a chest X-ray, and if something looks off, they'll get a more detailed scan to confirm. The goal is to s…

This study tests a program to help doctors and patients safely reduce or stop taking acid-reducing pills (proton pump inhibitors) when they are no longer needed. About 400 adults in Swiss primary care who take these pills daily will be enrolled. The goal is to see if the program …

This study looks at whether giving extra nutrition through a feeding tube before surgery can lower the chance of complications in malnourished people with esophageal or stomach cancer. About 670 participants will be followed to compare those who get nutritional support with those…

This study uses artificial intelligence to analyze patient data—like medical history, scans, and lab results—to predict how well esophageal cancer patients respond to chemoimmunotherapy before surgery. Researchers aim to build a model that identifies who achieves a complete respo…

This study looks at how the upper part of the esophagus (striated esophagus) works when people swallow. Researchers want to understand how the throat and esophagus work together. They will study healthy adults and people with swallowing problems. This is an observational study, n…

This study aims to collect normal measurements from the esophagus and stomach in 40 healthy adults aged 18-85. Participants will undergo two quick, FDA-approved tests during a standard upper endoscopy to measure muscle function and tissue health. The data will help doctors better…

This study is testing whether a quick, non-invasive test that measures heart rate and breathing patterns before thoracic surgery can help predict which patients are more likely to have complications after the operation. Researchers will enroll 130 adults undergoing major chest su…

This study collects blood, urine, and bone marrow samples from 620 people with solid cancers like lung, colorectal, and pancreatic cancer. Researchers will look for tumor cells and DNA in these samples to understand how cancer spreads and why it sometimes comes back after surgery…

This study observes 160 adults with oesophageal cancer to see if an endoscopic ultrasound (EUS) changes their treatment plan after standard scans. Researchers will also interview patients and doctors to understand their views on using EUS. The goal is to learn when this test is m…

This study follows 100 people newly diagnosed with esophageal cancer in Hungary. Researchers will track heart function, nutrition, physical ability, and mental health before and after surgery. The goal is to find which factors are linked to better survival and quality of life, so…

This study collects tissue, blood, and stool samples from 200 children with inflammatory bowel disease (IBD) or other gut disorders. Researchers will use a cutting-edge technique called spatial transcriptomics to map gene activity directly inside gut tissue. The goal is to better…

This study follows 300 teenagers born with esophageal atresia, a condition where the esophagus is not fully formed at birth. Researchers will track common long-term problems like acid reflux, breathing issues, and growth, and collect blood and tissue samples to look for biologica…

This study collects information from medical records and patient visits to see how well endoscopic bariatric therapies (EBTs) work for weight loss and if they are safe. It includes adults who have had or plan to have an EBT within six months. The goal is to track weight changes a…

This study compares how patients recover and feel after two types of surgery for esophageal cancer: minimally invasive (smaller cuts) versus open surgery. Researchers will track quality of life, pain, and daily function for up to three years in 3,500 participants. The goal is to …

This study is collecting medical history, blood, and tissue samples from 7,000 people with esophageal disorders like GERD or Barrett's esophagus. Researchers hope to find genetic or protein markers that signal a higher risk of developing esophageal cancer. The goal is to enable e…

This study tests an artificial intelligence tool that helps doctors see blood vessels during endoscopic procedures for achalasia or tumors. The AI aims to reduce the risk of bleeding and injury by spotting vessels faster and more accurately. Twenty participants will be enrolled t…

This study aims to understand why many cancer patients lose muscle and fat (cachexia), a condition that worsens their health. Researchers will use advanced techniques to analyze samples from 1000 adults with certain cancers. The goal is to find early warning signs and new targets…

This study is creating a large database of information from 10,000 people with esophagus problems like GERD, achalasia, and other motility disorders. Researchers will collect data from standard tests to better understand these conditions. The goal is to improve diagnosis and trea…

This study is collecting survey responses from 1,000 people who have had or will have surgery on their esophagus. The goal is to validate new questionnaires that measure recovery and symptoms. The information will help doctors set expected recovery scores and improve treatment pl…

This study looks at how the esophagus changes in people with a precancerous condition called Barrett's esophagus who are getting a treatment called radiofrequency ablation (RFA). Researchers will use two special devices during routine endoscopies to measure the tightness and heal…

This study tests a decision support tool for adults with eosinophilic esophagitis (EoE). About 40 participants will use either the tool or general education before a clinic visit. Researchers want to see if the tool is helpful and easy to use, and if it improves treatment knowled…

This study looks at whether eosinophilic gastritis, a rare stomach condition, causes problems with how the stomach moves food. Researchers will use a special scan after an oatmeal meal to check stomach emptying in 30 people. The goal is to better understand if these motility issu…

This study looks at how long people with type 2 diabetes need to stop taking GLP-1 medications (like semaglutide) before surgery to make sure their stomach is empty. These drugs slow down digestion, which can increase the risk of food or liquid entering the lungs during anesthesi…

This study reviews past medical records to see if people with esophageal cancer have better survival when treated at hospitals that perform many surgeries (more than 5 per year) compared to those that do fewer. The goal is to understand whether hospital experience and additional …

This study is creating a large database to compare two ways of taking tissue samples from the esophagus: standard forceps biopsies and a brush-based method called WATS3D. Researchers want to see if the brush method helps doctors find Barrett's esophagus or early warning signs of …

This study tests whether a new EUS-guided pressure measurement (EUS-PPGM) can predict how well varices respond to endoscopic banding in people with cirrhosis. Researchers will measure portal pressure in 160 patients and follow them for one year to see if higher pressure at 3 mont…

This study compares two surgical procedures for patients with a specific type of cancer where the stomach meets the esophagus. Half of the 120 participants will have only the upper part of the stomach removed (proximal gastrectomy), while the other half will have the entire stoma…

This study aims to find out how many children in the Czech Republic, aged 8-9 and 12-13, have symptomatic gastroesophageal reflux disease (GERD). Researchers will recruit 1,000 children through schools and ask them to complete an online questionnaire about reflux symptoms. Those …

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to cancer treatment can improve outcomes for people aged 70 and older with gastrointestinal cancers like stomach, colon, or pancreatic cancer. Researchers will test if an online …

This study is creating a registry of 500 patients with eosinophilic gastrointestinal disorders (EGIDs), including eosinophilic esophagitis, gastroenteritis, and colitis. Researchers will collect questionnaires, endoscopy images, biopsy samples, and physical exam findings to learn…

This study looks at factors that help blood clots in the main liver vein dissolve in people with liver scarring (cirrhosis) and enlarged stomach veins. Researchers will follow 1,500 patients over time to see what influences clot recovery. The goal is to help doctors and patients …

This study looks at tissue samples from 30 adults with stomach or esophageal cancer that spread to the brain. Researchers compare the genetic markers of the original tumor and the brain tumor to see if they differ. The goal is to better understand how these cancers change when th…

This study tests whether a newer, MRI-guided radiation method (MRgART) is gentler on the heart than standard radiation (LINAC) for people with lung, esophageal, or other chest cancers. About 60 adults will receive radiation and have their heart function checked via MRI and blood …

This study collects tissue samples from people with various advanced or early-stage cancers to train a diagnostic platform called Elephas. The goal is to see how accurately it can predict whether a patient will respond to immunotherapy or chemoimmunotherapy. About 324 participant…

This study aims to develop a simple tool to predict whether a person's stomach will still have food or liquid in it before a sedated endoscopy. Having a full stomach during sedation raises the risk of serious complications like choking. Researchers will study 5,000 adults to iden…

This study is testing whether an artificial intelligence (AI) system can predict how well esophageal cancer will respond to treatment and estimate a patient's long-term outlook. Researchers will collect medical images, genetic data, and other health information from 1,500 partici…

This study looks at how common Helicobacter pylori (a stomach germ linked to cancer) is in adults without stomach symptoms who are already getting a screening colonoscopy. About 1,000 participants will also have a stomach exam (gastroscopy) during the same visit, with small tissu…

This study reviews the medical records of about 4000 people who had surgery for esophageal cancer. The goal is to see how the amount of cancer left at the edges of the removed tissue affects how long people live. No new treatments are given; the study only looks at past informati…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study collects tissue, blood, urine, and stool samples from 5000 people undergoing colonoscopy or endoscopy, including those with cancer, polyps, or inflammatory bowel disease, as well as healthy volunteers. The goal is to find new biomarkers that could improve early detecti…

This study is testing whether a combined PET-MRI scan can help doctors plan radiation treatment more precisely for people with esophagogastric cancer. Fifteen participants will receive PET-MRI scans before, during, and after radiation therapy. The images will not be used for thei…

This study follows 150 adults with eosinophilic esophagitis (EoE) who are starting dupilumab as part of their normal care. Researchers will collect information on medical history, symptoms, and quality of life over two years to see how well the treatment works in real-world setti…

This study is testing whether a device called EndoFLIP can predict who will develop acid reflux after sleeve gastrectomy, a common weight-loss surgery. Researchers will measure the flexibility and function of the valve between the stomach and esophagus in 200 adults before surger…

This study looks at how well patients understand the information they get before major abdominal cancer surgery and whether that affects regret afterward. Researchers will survey 90 adults before surgery, then one month and three months after. The goal is to improve how doctors c…

This pilot study is testing whether cells collected by brushing the esophagus during a routine endoscopy can be genetically analyzed to better predict cancer risk in people with Barrett's esophagus. Researchers will collect brush samples, biopsies, and blood from 50 patients, the…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning earlier than standard scans. About 100 people with different solid tumors will give blood samples after treatment. The goal is to see if early detection can lead to better treatm…

This study uses a 20-25 minute survey to find out which features of diagnostic tests for gastro-esophageal cancer matter most to patients and the general public. Researchers aim to understand preferences and regional differences to improve screening decisions. About 2,200 adults …

This study is creating a large collection of medical data and biological samples from 1000 people with portal hypertension, a condition that can cause dangerous bleeding in the esophagus or stomach. The goal is to use advanced technologies like genetics and imaging to better unde…

This study compares a new orally disintegrating form of Trimedat (trimebutine) to the standard tablet in 36 healthy adults. The goal is to see if the new version is absorbed similarly and is safe. This trial does not treat any disease; it only gathers data on how the drug behaves…

This study is looking at whether people who take proton pump inhibitors (PPIs) for heartburn or acid reflux develop an overgrowth of bacteria in the small intestine. Researchers will use a simple breath test to check for this condition. The goal is to learn how common this proble…

This study looks at whether PET/CT scans can detect heart damage caused by radiation therapy in people with lung or esophageal cancer. About 20 participants will get special heart scans before, during, and after their radiation treatment. The goal is to see if the scans can pick …

This study aims to understand how the throat and esophagus normally prevent stomach contents from reaching the throat in people with GERD. Researchers will use a thin tube with sensors placed through the nose to measure pressure, acid, and liquid movement, along with a tiny camer…

This study tests whether different levels of exercise before surgery can increase immune cells inside oesophageal cancer tumors. Researchers will measure changes in fitness and immune response in 50 adults with resectable oesophageal adenocarcinoma. The goal is to find the best e…

This registry study is tracking 1,000 adults who are scheduled to undergo endoscopic submucosal dissection (ESD), a procedure that removes deep tumors from the digestive tract without major surgery. Researchers want to see how well ESD works in a Western population, measuring thi…

This study is a large registry that will collect information from about 1,900 people with advanced cancer of the esophagus or stomach who are receiving palliative treatment in Germany. The goal is to understand what treatments are actually used in everyday practice and how patien…

This study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …

This study looks at whether measuring a patient's energy reserve (fitness) before major cancer surgery can help predict how well they recover. Researchers will use a special exercise test to measure gas exchange and see if it relates to complications after surgery. The goal is to…

This study looks at whether single-use gastroscopes work just as well as reusable ones when used in the operating room for upper stomach exams. About 700 adults will take part, and researchers will compare how often each scope successfully completes the procedure. The goal is to …

This study is following 2000 adults with functional digestive disorders like irritable bowel syndrome, dyspepsia, and constipation. Researchers will collect medical data and biological samples (biopsies, blood, urine, stool) during routine care. The goal is to find markers that c…

This study looks at whether a specific gene, ALDH2, which helps break down alcohol, is linked to how long people with esophageal cancer live. Researchers will follow 700 patients for up to 12.5 years to see if gene variations affect survival. The goal is to better understand why …

This early-phase trial is testing two new antibody fragments that are designed to attach to a sugar molecule found on many solid tumors. The fragments are labeled with a radioactive tracer so they can be seen on PET/CT scans. The study aims to see where these fragments go in the …

This study follows 320 people who had omega gastric bypass surgery 10 years ago to compare long-term side effects between two surgical techniques (150 cm vs 200 cm loop). Researchers will check for serious complications, nutritional problems, and weight loss. The goal is to deter…

This study measures and compares post-traumatic stress in mothers (and some fathers) of children born with esophageal atresia, a condition where the esophagus doesn't connect properly. Researchers want to see if learning about the condition before birth (antenatal) versus after b…

This study looks at why some babies born with esophageal atresia develop dumping syndrome, a condition causing dangerous blood sugar drops after feeding. Researchers will monitor 15 infants with continuous glucose and heart monitors and a stomach-emptying scan at 3 months old. Th…

This study aims to find out how common acid reflux symptoms are in children with cystic fibrosis. Researchers will use a symptom questionnaire and, for some children, will stop their reflux medication to see if symptoms get worse. About 20 children aged 2 to 18 will take part.

This study at Stanford University collects tissue and blood samples from 100 adults with or at high inherited risk for stomach, esophageal, or related cancers. Researchers aim to understand how genes and proteins contribute to cancer development. The study does not test any treat…

This study looks at whether changes in DNA markers in the blood can show how well esophageal cancer treatment is working. Researchers will compare these markers with standard CT/MRI scans and tumor markers. The goal is to find a simpler, less invasive way to track treatment respo…

This study reviews medical records of 350 adults who had surgery for esophageal cancer in France between 2017 and 2024. Researchers want to understand how often infections happen after surgery, what causes them, and how they affect recovery. The goal is to find ways to prevent th…

This pilot study aims to see how common Barrett's esophagus is in people with eating disorders who have been purging (vomiting or ruminating) for at least 5 years. Researchers will use a simple, non-endoscopic device called EsoGuard to collect cell samples from the esophagus. The…

This study is following 10,000 adults with heart valve disease to see how their condition changes over time. Researchers will use scans, blood tests, and health records to track progression and the effects of treatments like surgery or medication. The goal is to better predict ou…

This study aims to collect blood, nasal fluid, skin cells, urine, and medical data from 10,000 people aged 3 to 100 with allergies, asthma, eczema, or sinus issues. Participants will have up to 3 years of follow-up visits and questionnaires. The goal is to create a large reposito…

This study follows 200 people with cancers of the esophagus, stomach, pancreas, colon, or rectum who are scheduled for surgery, along with some healthy controls. Researchers will track weight, muscle mass, physical activity, quality of life, and immune markers over a year to bett…