New drug pumitamig takes on nivolumab in stomach cancer showdown

NCT ID NCT07221149

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This study compares two drug combinations for people with advanced stomach, gastroesophageal junction, or esophageal cancer that hasn't been treated yet. One group gets pumitamig plus chemotherapy, the other gets nivolumab plus chemotherapy. The goal is to see which combo works better at shrinking tumors and extending life. About 690 participants will take part in this blinded, randomized trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pumitamig (also called BMS-986545, BNT327, PM8002)
What this could lead to: If pumitamig works better than nivolumab, it could offer a new first-line treatment option for people with advanced stomach or esophageal cancer, potentially improving tumor shrinkage and survival.
What could go wrong: This is an early-to-mid stage trial (phase 2/3), so results are not guaranteed. Pumitamig may not prove superior to the current standard (nivolumab), and side effects from combining it with chemotherapy could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus esophageal adenocarcinoma gastric adenocarcinoma gastric neoplasm gastroesophageal adenocarcinoma gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UNTREATED ADVANCED OR METASTATIC GASTRIC, GASTROESOPHAGEAL JUNCTION, OR ESOPHAGEAL ADENOCARCINOMA

Contacts and locations

Locations

AOU della Campania Luigi Vanvitelli
RECRUITING

Naples, Campania, 80138, Italy
Aichi Cancer Center Hospital
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Asan Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 05505, South Korea
Beijing Cancer hospital
RECRUITING

Beijing, Beijing Municipality, 100142, China
CHRU de Brest
RECRUITING

Brest, Finistère, 29609, France
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
RECRUITING

Nantes, Pays de la Loire Region, 44093, France
Centre Hospitalier Universitaire de Poitiers
RECRUITING

Poitiers, Vienne, 86021, France
Centre Leon Berard
RECRUITING

Lyon Cedex08, Auvergne-Rhône-Alpes, 69373, France
Centro Médico Fleischer
RECRUITING

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1414, Argentina
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC)
RECRUITING

Buenos Aires, C1431FWO, Argentina
Centro de Investigação Clínica Ciências Médicas
RECRUITING

Belo Horizonte, Minas Gerais, 30140-085, Brazil
Centrul de Oncologie "Sfântul Nectarie"
RECRUITING

Craiova, Dolj, 200542, Romania
Charité - Universitaetsmedizin Berlin - Campus Bejnamin Franklin
RECRUITING

Berlin, 10117, Germany
Clinica Viver
RECRUITING

Santa Maria, Rio Grande do Sul, 97015-373, Brazil
Complejo Hospitalario de Navarra
RECRUITING

Pamplona, Navarre, 31009, Spain
Emory University
RECRUITING

Atlanta, Georgia, 30308, United States
Facharztzentrum Eppendorf
RECRUITING

Hamburg, 20249, Germany
Faculdade de Medicina de Sao Jose do Rio Preto
RECRUITING

São José do Rio Preto, 15090-000, Brazil
Florida Cancer Specialists - North
RECRUITING

St. Petersburg, Florida, 33701, United States
Florida Cancer Specialists - South
RECRUITING

Fort Myers, Florida, 33901, United States
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
RECRUITING

Roma, 00168, Italy
Fujian Cancer Hospital
RECRUITING

Fuzhou, Fujian, 350014, China
Guangxi Medical University Affiliated Tumor Hospital
RECRUITING

Nanning, Guangxi, 530200, China
H.R.U Málaga - Hospital General
RECRUITING

Málaga, 29011, Spain
Hopital Claude Huriez - CHU de Lille
RECRUITING

Lille, Nord, 59000, France
Hospital Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Clinico de Valencia
RECRUITING

Valencia, Valenciana, Comunitat, 46010, Spain
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28007, Spain
Hospital Italiano de Buenos Aires
RECRUITING

ABB, Buenos Aires F.D., C1199ABB, Argentina
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Marqués de Valdecilla
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital de Clinicas de Porto Alegre
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Hôpital Européen Georges Pompidou
RECRUITING

Paris, 75015, France
Instituto Alexander Fleming
RECRUITING

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina
Institutul Oncologic Cluj
RECRUITING

Cluj-Napoca, 400015, Romania
Institutul Regional de Gastroenterologie și Hepatologie Prof. Dr. Octavian Fodor
RECRUITING

Cluj-Napoca, Cluj, 400162, Romania
Institutul Regional de Oncologie
RECRUITING

Iași, 700483, Romania
Istituto Oncologico Veneto IRCCS
RECRUITING

Padova, Veneto, 35128, Italy
Krankenhaus Nordwest GmbH
RECRUITING

Frankfurt, 60488, Germany
Liga Norte Riograndense Contra o Câncer
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil
Local Institution - 0002
NOT_YET_RECRUITING

Minami-Ku, Fukuoka, 811-1347, Japan
Local Institution - 0004
NOT_YET_RECRUITING

Osaka, Osaka, 5418567, Japan
Local Institution - 0006
NOT_YET_RECRUITING

Gifu, 501-1194, Japan
Local Institution - 0012
NOT_YET_RECRUITING

Matsuyama, Ehime, 791-0280, Japan
Local Institution - 0014
NOT_YET_RECRUITING

Chiba, Chiba, 260-8717, Japan
Local Institution - 0015
NOT_YET_RECRUITING

Yokohama, Kanagawa, 2418515, Japan
Local Institution - 0024
NOT_YET_RECRUITING

Sendai, 980-8574, Japan
Local Institution - 0026
NOT_YET_RECRUITING

Nagaizumi-cho,Sunto-gun, Shizuoka, 411-8777, Japan
Local Institution - 0029
NOT_YET_RECRUITING

Kurashiki, Okayama-ken, 710-8602, Japan
Local Institution - 0055
NOT_YET_RECRUITING

Santiago, Santiago Metropolitan, 8420383, Chile
Local Institution - 0056
NOT_YET_RECRUITING

Santiago, Santiago Metropolitan, 7710007, Chile
Local Institution - 0060
NOT_YET_RECRUITING

Marseille, 13385, France
Local Institution - 0068
NOT_YET_RECRUITING

Santiago, Santiago Metropolitan, 7500921, Chile
Local Institution - 0088
NOT_YET_RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Local Institution - 0093
NOT_YET_RECRUITING

Manisa, 45030, Turkey (Türkiye)
Local Institution - 0108
NOT_YET_RECRUITING

Edirne, 22030, Turkey (Türkiye)
Local Institution - 0111
NOT_YET_RECRUITING

Ankara, 06230, Turkey (Türkiye)
Local Institution - 0112
NOT_YET_RECRUITING

Leipzig, 04103, Germany
Local Institution - 0119
NOT_YET_RECRUITING

Halifax, Nova Scotia, B3H 3A7, Canada
Local Institution - 0125
NOT_YET_RECRUITING

Kadiköy/Istanbul, 41380, Turkey (Türkiye)
Local Institution - 0128
NOT_YET_RECRUITING

Sakarya, 54100, Turkey (Türkiye)
Local Institution - 0166
NOT_YET_RECRUITING

Turin, Piedmont, 10126, Italy
Local Institution - 0175
NOT_YET_RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Local Institution - 0176
NOT_YET_RECRUITING

Liverpool, New South Wales, 2170, Australia
Local Institution - 0222
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Local Institution - 0232
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510000, China
Local Institution - 0237
NOT_YET_RECRUITING

Harbin, Heilongjiang, 150081, China
Local Institution - 0243
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030001, China
Local Institution - 0244
NOT_YET_RECRUITING

Shenyang, Liaoning, 110042, China
Local Institution - 0245
NOT_YET_RECRUITING

Chapel Hill, North Carolina, 27599, United States
Local Institution - 0248
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300060, China
Local Institution - 0249
NOT_YET_RECRUITING

Zhengzhou, Henan, 450008, China
Local Institution - 0252
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310052, China
Local Institution - 0256
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210009, China
Local Institution - 0259
NOT_YET_RECRUITING

Rochester, Minnesota, 55905, United States
Local Institution - 0260
NOT_YET_RECRUITING

Chengdu, Sichuan, 610041, China
Local Institution - 0268
NOT_YET_RECRUITING

Iowa City, Iowa, 52242, United States
Local Institution - 0269
NOT_YET_RECRUITING

Shanghai, 200032, China
Local Institution - 0273
NOT_YET_RECRUITING

Jinan, Shandong, 250117, China
Local Institution - 0274
NOT_YET_RECRUITING

Rochester, New York, 14642, United States
Local Institution - 0279
NOT_YET_RECRUITING

Wuhan, Hubei, 430079, China
Local Institution - 0282
NOT_YET_RECRUITING

Weihui, Henan, 453100, China
Local Institution - 0284
NOT_YET_RECRUITING

Phoenix, Arizona, 85054, United States
Local Institution - 0286
NOT_YET_RECRUITING

Omaha, Nebraska, 68198, United States
Local Institution - 0292
NOT_YET_RECRUITING

Changsha, Hunan, 410031, China
Local Institution - 0300
NOT_YET_RECRUITING
Local Institution - 0302
NOT_YET_RECRUITING

Puducherry, 605006, India
Local Institution - 0305
NOT_YET_RECRUITING

Mumbai, Maharashtra, 400012, India
Local Institution - 0306
NOT_YET_RECRUITING

Nashik, Dādra and Nagar Haveli and Damān and Diu, 422001, India
Local Institution - 0310
NOT_YET_RECRUITING

Pune, 411001, India
Local Institution - 0354
NOT_YET_RECRUITING

Glasgow, G12 0YN, United Kingdom
Local Institution - 0376
NOT_YET_RECRUITING

Takatsuki, Osaka, 569-8686, Japan
Local Institution - 0379
NOT_YET_RECRUITING

Chicago, Illinois, 60637, United States
Local Institution - 0388
NOT_YET_RECRUITING

Barcelona, Barcelona [Barcelona], 08035, Spain
Local Institution - 0394
NOT_YET_RECRUITING

Oaxaca City, Oaxaca, 68020, Mexico
Local Institution - 0395
NOT_YET_RECRUITING

Mexico City, Mexico City, 14000, Mexico
Local Institution - 0396
NOT_YET_RECRUITING

Mexico City, DIF, 03100, Mexico
Local Institution - 0397
NOT_YET_RECRUITING

Mexico City, Mexico City, 14000, Mexico
Local Institution - 0398
NOT_YET_RECRUITING

Cali, Valle del Cauca Department, 760032, Colombia
Local Institution - 0399
NOT_YET_RECRUITING

Pasto, Departamento de Nariño, 520001, Colombia
Local Institution - 0403
NOT_YET_RECRUITING

Delhi, 110029, India
Local Institution - 0408
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310003, China
Local Institution - 0409
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330006, China
Local Institution - 0428
NOT_YET_RECRUITING

San Francisco, California, 94158, United States
Local Institution - 0433
NOT_YET_RECRUITING

Jacksonville, Florida, 32224, United States
Local Institution - 0437
NOT_YET_RECRUITING

Los Angeles, California, 90033, United States
Local Institution - 0440
NOT_YET_RECRUITING

Yangzhou, Jiangsu, 225001, China
Local Institution - 0443
NOT_YET_RECRUITING

Cleveland, Ohio, 44106, United States
Lyell McEwin Hospital
RECRUITING

Elizabeth Vale, South Australia, 5112, Australia
Mazowiecki Szpital Onkologiczny
RECRUITING

Warsaw, Masovian Voivodeship, 03-411, Poland
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Missouri Cancer Associates
RECRUITING

Columbia, Missouri, 65201, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
RECRUITING

Warsaw, Masovian Voivodeship, 02-034, Poland
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
Nationales Centrum Fur Tumorerkrankungen (Nct)
RECRUITING

Heidelberg, 69120, Germany
Northwell Health/ RJ Zuckerberg Cancer Center
RECRUITING

Lake Success, New York, 11042, United States
Northwest Cancer Specialists, P.C.
RECRUITING

Portland, Oregon, 97213-2982, United States
Núcleo de Oncologia e Hematologia do Ceará
RECRUITING

Fortaleza, Ceará, 60115-281, Brazil
Oncology Associates Of Oregon, Pc
RECRUITING

Eugene, Oregon, 97401, United States
Oncology and Hematology Associates of Southwest Virginia, Inc. - Salem
RECRUITING

Salem, Virginia, 24153, United States
Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Oxford University Hospitals NHS Trust
RECRUITING

Oxford, Oxfordshire, OX3 7LJ, United Kingdom
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Royal Marsden Hospital
RECRUITING

London, SW3 6JJ, United Kingdom
S.C. Centrul de Oncologie Euroclinic S.R.L.
RECRUITING

Iași, 700106, Romania
SC Radiotherapy Center Cluj SRL
RECRUITING

Florești, Cluj, 407280, Romania
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu
RECRUITING

Opole, Opole Voivodeship, 45-061, Poland
Samsung Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea
Seoul National University Bundang Hospital
RECRUITING

Seongnam, Kyǒnggi-do, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 03722, South Korea
Shanghai East Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200120, China
St Bartholomew's Hospital
RECRUITING

London, London, City of, EC1A 7BE, United Kingdom
St. John of God Murdoch Hospital
RECRUITING

Murdoch, Western Australia, 6150, Australia
Sunshine Coast University Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia
Tennessee Oncology
RECRUITING

Nashville, Tennessee, 37203, United States
Texas Oncology
RECRUITING

Beaumont, Texas, 77702, United States
Texas Oncology - Amarillo Cancer Center
RECRUITING

Amarillo, Texas, 79124, United States
Texas Oncology - DFW
RECRUITING

Grapevine, Texas, 76051, United States
Texas Oncology - Northeast Texas
RECRUITING

Denison, Texas, 75020, United States
Texas Oncology - San Antonio
RECRUITING

San Antonio, Texas, 78240, United States
Texas Oncology-Austin Central
RECRUITING

Austin, Texas, 78731, United States
The Cancer Institute Hospital of JFCR
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
The Royal Marsden NHS Foundation Trust - Royal Marsden Hospital (RMH) - Sutton
RECRUITING

Sutton, Surrey, SM2 5PT, United Kingdom
The Sixth Affiliated Hospital of Sun Yat-sen University
RECRUITING

Guangzhou, Guangdong, 510655, China
The University of Osaka Hospital
RECRUITING

Suita, Osaka, 565-0871, Japan
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Universitaetsklinikum Ulm
RECRUITING

Ulm, 89081, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
RECRUITING

Mainz, 55131, Germany
University of California, Irvine (UCI) Health - UC Irvine Medical Center
RECRUITING

Orange, California, 92868, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States
Universitätsmedizin Mannheim
RECRUITING

Mannheim, 68167, Germany
Warringal Medical Centre
RECRUITING

Melbourne, Victoria, 3084, Australia
Wojewódzkie Centrum Szpitalne Kotliny Jeleniogórskiej
RECRUITING

Jelenia Góra, 58-506, Poland

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