New drug pumitamig takes on nivolumab in stomach cancer showdown

NCT ID NCT07221149

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two drug combinations for people with advanced stomach, gastroesophageal junction, or esophageal cancer that hasn't been treated yet. One group gets pumitamig plus chemotherapy, the other gets nivolumab plus chemotherapy. The goal is to see which combo works better at shrinking tumors and extending life. About 690 participants will take part in this blinded, randomized trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

pumitamig (also called BMS-986545, BNT327, PM8002)

What this could lead to

If pumitamig works better than nivolumab, it could offer a new first-line treatment option for people with advanced stomach or esophageal cancer, potentially improving tumor shrinkage and survival.

What could go wrong

This is an early-to-mid stage trial (phase 2/3), so results are not guaranteed. Pumitamig may not prove superior to the current standard (nivolumab), and side effects from combining it with chemotherapy could be significant.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus esophageal adenocarcinoma gastric adenocarcinoma gastric neoplasm gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

UNTREATED ADVANCED OR METASTATIC GASTRIC, GASTROESOPHAGEAL JUNCTION , OR ESOPHAGEAL ADENOCARCINOMA

Contacts and locations

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Study contacts

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AOU della Campania Luigi Vanvitelli
RECRUITING

Naples, Campania, 80138, Italy

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Asan Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 05505, South Korea

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Beijing Cancer hospital
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Beijing, Beijing Municipality, 100142, China

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CHRU de Brest
RECRUITING

Brest, Finistère, 29609, France

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Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
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Nantes, Pays de la Loire Region, 44093, France

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Centre Hospitalier Universitaire de Poitiers
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Poitiers, Vienne, 86021, France

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Centre Leon Berard
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Lyon Cedex08, Auvergne-Rhône-Alpes, 69373, France

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Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC)
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Buenos Aires, C1431FWO, Argentina

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Centro de Investigação Clínica Ciências Médicas
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Belo Horizonte, Minas Gerais, 30140-085, Brazil

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Centrul de Oncologie "Sfântul Nectarie"
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Craiova, Dolj, 200542, Romania

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Charité - Universitaetsmedizin Berlin - Campus Bejnamin Franklin
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Berlin, 10117, Germany

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Clinica Viver
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Santa Maria, Rio Grande do Sul, 97015-373, Brazil

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Complejo Hospitalario de Navarra
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Pamplona, Navarre, 31009, Spain

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Facharztzentrum Eppendorf
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Hamburg, 20249, Germany

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Faculdade de Medicina de Sao Jose do Rio Preto
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São José do Rio Preto, 15090-000, Brazil

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Florida Cancer Specialists - North
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St. Petersburg, Florida, 33701, United States

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Florida Cancer Specialists - South
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Fort Myers, Florida, 33901, United States

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Fondazione IRCCS Istituto Nazionale dei Tumori
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Milan, 20133, Italy

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Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
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Roma, 00168, Italy

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Fujian Cancer Hospital
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Fuzhou, Fujian, 350014, China

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Guangxi Medical University Affiliated Tumor Hospital
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Nanning, Guangxi, 530200, China

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H.R.U Málaga - Hospital General
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Málaga, 29011, Spain

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Hopital Claude Huriez - CHU de Lille
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Lille, Nord, 59000, France

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Hospital Clinico San Carlos
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Madrid, 28040, Spain

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Hospital Clinico de Valencia
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Valencia, Valenciana, Comunitat, 46010, Spain

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Hospital Italiano de Buenos Aires
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ABB, Buenos Aires F.D., C1199ABB, Argentina

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Hospital Universitario La Paz
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Madrid, 28046, Spain

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Hospital Universitario Marqués de Valdecilla
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Santander, Cantabria, 39008, Spain

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Hospital de Clinicas de Porto Alegre
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Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

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Hôpital Européen Georges Pompidou
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Paris, 75015, France

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Instituto Alexander Fleming
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Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

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Institutul Oncologic Cluj
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Cluj-Napoca, 400015, Romania

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Institutul Regional de Gastroenterologie și Hepatologie Prof. Dr. Octavian Fodor
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Cluj-Napoca, Cluj, 400162, Romania

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Institutul Regional de Oncologie
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Iași, 700483, Romania

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Istituto Oncologico Veneto IRCCS
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Padova, Veneto, 35128, Italy

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Krankenhaus Nordwest GmbH
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Frankfurt, 60488, Germany

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Local Institution - 0002
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Minami-Ku, Fukuoka, 811-1347, Japan

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Local Institution - 0004
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Osaka, Osaka, 5418567, Japan

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Local Institution - 0006
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Gifu, 501-1194, Japan

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Local Institution - 0012
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Matsuyama, Ehime, 791-0280, Japan

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Chikusa-ku, 464-8681, Japan

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Chiba, Chiba, 260-8717, Japan

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Local Institution - 0015
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Yokohama, Kanagawa, 2418515, Japan

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Local Institution - 0024
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Sendai, 980-8574, Japan

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Local Institution - 0026
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Nagaizumi-cho,Sunto-gun, Shizuoka, 411-8777, Japan

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Kurashiki, Okayama-ken, 710-8602, Japan

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Local Institution - 0055
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Santiago, Santiago Metropolitan, 8420383, Chile

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Santiago, Santiago Metropolitan, 7710007, Chile

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Marseille, 13385, France

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Santiago, Santiago Metropolitan, 7500921, Chile

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Buenos Aires, 1039, Argentina

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Calgary, Alberta, T2N 5G2, Canada

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Manisa, 45030, Turkey (Türkiye)

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Edirne, 22030, Turkey (Türkiye)

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Ankara, 06230, Turkey (Türkiye)

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Leipzig, 04103, Germany

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Local Institution - 0119
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Halifax, Nova Scotia, B3H 3A7, Canada

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Local Institution - 0125
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Kadiköy/Istanbul, 41380, Turkey (Türkiye)

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Sakarya, 54100, Turkey (Türkiye)

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Local Institution - 0166
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Turin, Piedmont, 10126, Italy

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Local Institution - 0175
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Sherbrooke, Quebec, J1H 5N4, Canada

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Liverpool, New South Wales, 2170, Australia

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Fortaleza, Ceará, 60115-280, Brazil

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Local Institution - 0222
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Cleveland, Ohio, 44195, United States

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Natal/RN, Rio Grande do Norte, 59062-000, Brazil

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Local Institution - 0232
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Guangzhou, Guangdong, 510000, China

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Local Institution - 0233
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Houston, Texas, 77030, United States

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Local Institution - 0237
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Harbin, Heilongjiang, 150081, China

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Taiyuan, Shanxi, 030001, China

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Shenyang, Liaoning, 110042, China

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Chapel Hill, North Carolina, 27599, United States

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Tampa, Florida, 33612, United States

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Tianjin, Tianjin Municipality, 300060, China

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Local Institution - 0249
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Zhengzhou, Henan, 450008, China

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Local Institution - 0252
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Hangzhou, Zhejiang, 310052, China

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Local Institution - 0255
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Nashville, Tennessee, 37203, United States

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Local Institution - 0256
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Nanjing, Jiangsu, 210009, China

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Local Institution - 0259
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Rochester, Minnesota, 55905, United States

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Local Institution - 0260
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Chengdu, Sichuan, 610041, China

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Local Institution - 0268
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Iowa City, Iowa, 52242, United States

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Local Institution - 0269
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Shanghai, 200032, China

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Local Institution - 0273
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Jinan, Shandong, 250117, China

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Local Institution - 0274
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Rochester, New York, 14642, United States

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Local Institution - 0279
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Wuhan, Hubei, 430079, China

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Local Institution - 0280
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Guangzhou, Guangdong, 510655, China

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Weihui, Henan, 453100, China

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Local Institution - 0284
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Phoenix, Arizona, 85054, United States

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Local Institution - 0286
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Omaha, Nebraska, 68198, United States

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Local Institution - 0292
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Changsha, Hunan, 410031, China

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Local Institution - 0300
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Local Institution - 0302
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Puducherry, 605006, India

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Local Institution - 0305
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Mumbai, Maharashtra, 400012, India

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Local Institution - 0306
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Nashik, Dādra and Nagar Haveli and Damān and Diu, 422001, India

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Local Institution - 0310
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Pune, 411001, India

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Local Institution - 0354
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Glasgow, G12 0YN, United Kingdom

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Local Institution - 0357
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Sutton, SM2 5PT, United Kingdom

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Local Institution - 0376
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Takatsuki, Osaka, 569-8686, Japan

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Local Institution - 0377
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Atlanta, Georgia, 30308, United States

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Local Institution - 0379
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Chicago, Illinois, 60637, United States

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Local Institution - 0388
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Barcelona, Barcelona [Barcelona], 08035, Spain

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Local Institution - 0389
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Madrid, 28028, Spain

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Local Institution - 0394
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Oaxaca City, Oaxaca, 68020, Mexico

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Local Institution - 0395
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Mexico City, Mexico City, 14000, Mexico

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Local Institution - 0396
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Mexico City, DIF, 03100, Mexico

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Local Institution - 0397
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Mexico City, Mexico City, 14000, Mexico

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Local Institution - 0398
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Cali, Valle del Cauca Department, 760032, Colombia

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Local Institution - 0399
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Pasto, Departamento de Nariño, 520001, Colombia

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Local Institution - 0403
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Delhi, 110029, India

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Local Institution - 0407
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Pittsburgh, Pennsylvania, 15213, United States

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Local Institution - 0408
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Hangzhou, Zhejiang, 310003, China

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Local Institution - 0409
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Nanchang, Jiangxi, 330006, China

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Local Institution - 0428
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San Francisco, California, 94158, United States

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Local Institution - 0433
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Jacksonville, Florida, 32224, United States

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Local Institution - 0437
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Los Angeles, California, 90033, United States

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Local Institution - 0440
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Yangzhou, Jiangsu, 225001, China

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Local Institution - 0443
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Cleveland, Ohio, 44106, United States

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Local Institution - 0444
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Sutton, Surrey, SM2 5PT, United Kingdom

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Lyell McEwin Hospital
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Elizabeth Vale, South Australia, 5112, Australia

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Mazowiecki Szpital Onkologiczny
RECRUITING

Warsaw, Masovian Voivodeship, 03-411, Poland

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Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

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Missouri Cancer Associates
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Columbia, Missouri, 65201, United States

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Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia

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Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
RECRUITING

Warsaw, Masovian Voivodeship, 02-034, Poland

Contact Phone: •••-•••-••••
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan

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National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan

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Nationales Centrum Fur Tumorerkrankungen (Nct)
RECRUITING

Heidelberg, 69120, Germany

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Northwell Health/ RJ Zuckerberg Cancer Center
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Lake Success, New York, 11042, United States

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Northwest Cancer Specialists, P.C.
RECRUITING

Portland, Oregon, 97213-2982, United States

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Oncology Associates Of Oregon, Pc
RECRUITING

Eugene, Oregon, 97401, United States

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Oncology and Hematology Associates of Southwest Virginia, Inc. - Salem
RECRUITING

Salem, Virginia, 24153, United States

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Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy

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Oxford University Hospitals NHS Trust
RECRUITING

Oxford, Oxfordshire, OX3 7LJ, United Kingdom

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Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

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S.C. Centrul de Oncologie Euroclinic S.R.L.
RECRUITING

Iași, 700106, Romania

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SC Radiotherapy Center Cluj SRL
RECRUITING

Florești, Cluj, 407280, Romania

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SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States

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SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu
RECRUITING

Opole, Opole Voivodeship, 45-061, Poland

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Samsung Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea

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Seoul National University Bundang Hospital
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Seongnam, Kyǒnggi-do, 13620, South Korea

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Seoul National University Hospital
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Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea

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Severance Hospital, Yonsei University Health System
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Seoul, Seoul-teukbyeolsi [Seoul], 03722, South Korea

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Shanghai East Hospital
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Shanghai, Shanghai Municipality, 200120, China

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St Bartholomew's Hospital
RECRUITING

London, London, City of, EC1A 7BE, United Kingdom

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St. John of God Murdoch Hospital
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Murdoch, Western Australia, 6150, Australia

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Sunshine Coast University Hospital
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Birtinya, Queensland, 4575, Australia

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Texas Oncology
RECRUITING

Beaumont, Texas, 77702, United States

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Texas Oncology - Amarillo Cancer Center
RECRUITING

Amarillo, Texas, 79124, United States

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Texas Oncology - DFW
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Grapevine, Texas, 76051, United States

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Texas Oncology - Northeast Texas
RECRUITING

Denison, Texas, 75020, United States

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Texas Oncology - San Antonio
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San Antonio, Texas, 78240, United States

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Texas Oncology-Austin Central
RECRUITING

Austin, Texas, 78731, United States

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The Cancer Institute Hospital of JFCR
RECRUITING

Koto-ku, Tokyo, 135-8550, Japan

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The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom

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The University of Osaka Hospital
RECRUITING

Suita, Osaka, 565-0871, Japan

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Universitaetsklinikum Ulm
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Ulm, 89081, Germany

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Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
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Mainz, 55131, Germany

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University of California, Irvine (UCI) Health - UC Irvine Medical Center
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Orange, California, 92868, United States

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University of Wisconsin Carbone Cancer Center - University Hospital
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Madison, Wisconsin, 53792, United States

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Universitätsmedizin Mannheim
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Mannheim, 68167, Germany

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Warringal Medical Centre
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Melbourne, Victoria, 3084, Australia

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Wojewódzkie Centrum Szpitalne Kotliny Jeleniogórskiej
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Jelenia Góra, 58-506, Poland

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