New pfizer combo aims to outperform current therapy for stomach cancer

NCT ID NCT07392892

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study tests a new experimental drug, PF-08634404, combined with chemotherapy in people with advanced stomach, gastroesophageal junction, or esophageal cancer that has not been treated before. The trial has two parts: first checking safety and response, then comparing the new combo to an approved treatment (nivolumab plus chemo). About 840 participants will take part to see which approach works better at shrinking tumors and extending life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF-08634404 (also known as SSGJ-707) given intravenously with chemotherapy
What this could lead to: If it works, this could offer a new first-line treatment option for people with advanced stomach or esophageal cancer, potentially improving how long they live or delaying cancer growth.
What could go wrong: This is an early-to-mid stage trial (Phase 2/3), so the drug may not prove better than the existing treatment (nivolumab plus chemo). Side effects from the combination are unknown and could be serious.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus esophageal adenocarcinoma gastric adenocarcinoma gastric cancer gastric neoplasm gastroesophageal cancer gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL ADENOCARCINOMA GASTROESOPHAGEAL JUNCTION CANCER METASTATIC GASTRIC CANCER UNTREATED ADVANCED OR METASTATIC GASTRIC, GASTROESOPHAGEAL JUNCTION, OR ESOPHAGEAL ADENOCARCINOMA

Contacts and locations

Locations

Aichi Cancer Center
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Alliance Cancer Specialists, PC
RECRUITING

Bensalem, Pennsylvania, 19020, United States
Alliance Cancer Specialists, PC
RECRUITING

Doylestown, Pennsylvania, 18901, United States
Alliance Cancer Specialists, PC
RECRUITING

Horsham, Pennsylvania, 19044, United States
Alliance Cancer Specialists, PC
RECRUITING

Langhorne, Pennsylvania, 19047, United States
Alliance Cancer Specialists, PC
RECRUITING

Media, Pennsylvania, 19063, United States
Alliance Cancer Specialists, PC
RECRUITING

Sellersville, Pennsylvania, 18960, United States
Alliance Cancer Specialists, PC
RECRUITING

Wynnewood, Pennsylvania, 19096, United States
Atlantic Health System
NOT_YET_RECRUITING

Morristown, New Jersey, 07960, United States
Atlantic Health System / Overlook Medical Center
NOT_YET_RECRUITING

Summit, New Jersey, 07901, United States
Illinois Cancer Specialists
RECRUITING

Arlington Heights, Illinois, 60005, United States
Illinois Cancer Specialists
RECRUITING

Chicago, Illinois, 60631, United States
Illinois Cancer Specialists
RECRUITING

Niles, Illinois, 60714, United States
Illinois CancerCare - Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare - Galesburg
RECRUITING

Galesburg, Illinois, 61401, United States
Illinois CancerCare, P.C.
RECRUITING

Peoria, Illinois, 61615, United States
Illinois CancerCare-Ottawa-Fox River Cancer Center
RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peru - Valley Regional Cancer Center
RECRUITING

Peru, Illinois, 61354, United States
Illinois CancerCare-Washington
RECRUITING

Washington, Illinois, 61571, United States
Istituto Europeo di Oncologia IRCCS
NOT_YET_RECRUITING

Milan, 20141, Italy
Maryland Oncology Hematology, P.A.
RECRUITING

Annapolis, Maryland, 21401, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Bethesda, Maryland, 20817, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Brandywine, Maryland, 20613, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Columbia, Maryland, 21044, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Germantown, Maryland, 20876, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Largo, Maryland, 20774, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Rockville, Maryland, 20850, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Silver Spring, Maryland, 20904, United States
National Cheng Kung University Hospital
NOT_YET_RECRUITING

Tainan, 704302, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
Oncology Hematology Care Clinical Trials, LLC
RECRUITING

Cincinnati, Ohio, 45211, United States
Oncology Hematology Care Clinical Trials, LLC
RECRUITING

Cincinnati, Ohio, 45242, United States
Oncology Hematology Care Clinical Trials, LLC
RECRUITING

Cincinnati, Ohio, 45245, United States
Oncology Hematology Care Clinical Trials, LLC
RECRUITING

Fairfield, Ohio, 45014, United States
Pan American Center for Oncology Trials, LLC - Bayamón Office
RECRUITING

Bayamón, 00959, Puerto Rico
Pan American Center for Oncology Trials, LLC - Manati Office
RECRUITING

Manati, United States, 00674, Puerto Rico
Rabin Medical Center
RECRUITING

Petah Tikva, Central District, 4941492, Israel
Renown Health Medical Oncology
RECRUITING

Reno, Nevada, 89502, United States
Renown Office of Clinical Research
RECRUITING

Reno, Nevada, 89502, United States
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Aurora, Colorado, 80012, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Boulder, Colorado, 80303, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Centennial, Colorado, 80112, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Colorado Springs, Colorado, 80907, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Colorado Springs, Colorado, 80923, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Denver, Colorado, 80218, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Denver, Colorado, 80220, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Englewood, Colorado, 80113, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Lakewood, Colorado, 80228, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Littleton, Colorado, 80120, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Lone Tree, Colorado, 80124, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Longmont, Colorado, 80504, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Pueblo, Colorado, 81003, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Thornton, Colorado, 80260, United States
Sheba Medical Center
RECRUITING

Ramat Gan, HA Merkaz, 5265601, Israel
Sourasky Medical Center
RECRUITING

Tel Aviv, TELL ABĪB, 6423906, Israel
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
US Oncology Investigational Products Center (IPC)
RECRUITING

Irving, Texas, 75063, United States
Virginia Cancer Specialists, PC
RECRUITING

Arlington, Virginia, 22201, United States
Virginia Cancer Specialists, PC
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Cancer Specialists, PC
RECRUITING

Manassas, Virginia, 20110, United States
Virginia Cancer Specialists, PC
RECRUITING

Reston, Virginia, 20190, United States
Virginia Cancer Specialists, PC
RECRUITING

Woodbridge, Virginia, 22191, United States
Virginia Oncology Associates
RECRUITING

Chesapeake, Virginia, 23320, United States
Virginia Oncology Associates
RECRUITING

Hampton, Virginia, 23666, United States
Virginia Oncology Associates
RECRUITING

Newport News, Virginia, 23606, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
Virginia Oncology Associates
RECRUITING

Virginia Beach, Virginia, 23456, United States
Zhongshan Hospital,Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 200031, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.