New combo therapy aims to fight tough stomach cancers

NCT ID NCT07392892

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Feb 06, 2026 · Last updated Apr 28, 2026 · Updated 11 times

Summary

This study tests a new medicine (PF-08634404) combined with chemotherapy for people with advanced stomach, gastroesophageal junction, or esophageal cancer that has not been treated before. The trial has two parts: first to check safety and response, then to compare the new combo against another approved treatment (nivolumab plus chemo). About 840 adults with good organ function and PD-L1 positive, HER2-negative tumors can join.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Alliance Cancer Specialists, PC
RECRUITING

Bensalem, Pennsylvania, 19020, United States
Alliance Cancer Specialists, PC
RECRUITING

Doylestown, Pennsylvania, 18901, United States
Alliance Cancer Specialists, PC
RECRUITING

Langhorne, Pennsylvania, 19047, United States
Alliance Cancer Specialists, PC
RECRUITING

Media, Pennsylvania, 19063, United States
Alliance Cancer Specialists, PC
RECRUITING

Sellersville, Pennsylvania, 18960, United States
Alliance Cancer Specialists, PC
RECRUITING

Wynnewood, Pennsylvania, 19096, United States
Illinois Cancer Specialists
RECRUITING

Arlington Heights, Illinois, 60005, United States
Illinois Cancer Specialists
RECRUITING

Chicago, Illinois, 60631, United States
Illinois Cancer Specialists
RECRUITING

Niles, Illinois, 60714, United States
Illinois CancerCare - Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare - Galesburg
RECRUITING

Galesburg, Illinois, 61401, United States
Illinois CancerCare, P.C.
RECRUITING

Peoria, Illinois, 61615, United States
Illinois CancerCare-Ottawa-Fox River Cancer Center
RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peru - Valley Regional Cancer Center
RECRUITING

Peru, Illinois, 61354, United States
Illinois CancerCare-Washington
RECRUITING

Washington, Illinois, 61571, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Annapolis, Maryland, 21401, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Bethesda, Maryland, 20817, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Brandywine, Maryland, 20613, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Columbia, Maryland, 21044, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Germantown, Maryland, 20876, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Largo, Maryland, 20774, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Rockville, Maryland, 20850, United States
Maryland Oncology Hematology, P.A.
RECRUITING

Silver Spring, Maryland, 20904, United States
Oncology Hematology Care Clinical Trials, LLC
RECRUITING

Cincinnati, Ohio, 45211, United States
Oncology Hematology Care Clinical Trials, LLC
RECRUITING

Cincinnati, Ohio, 45242, United States
Oncology Hematology Care Clinical Trials, LLC
RECRUITING

Cincinnati, Ohio, 45245, United States
Oncology Hematology Care Clinical Trials, LLC
RECRUITING

Fairfield, Ohio, 45014, United States
Pan American Center for Oncology Trials, LLC - Manati Office
NOT_YET_RECRUITING

Manati, United States, 00674, Puerto Rico
Renown Health Medical Oncology
RECRUITING

Reno, Nevada, 89502, United States
Renown Office of Clinical Research
RECRUITING

Reno, Nevada, 89502, United States
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Aurora, Colorado, 80012, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Boulder, Colorado, 80303, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Centennial, Colorado, 80112, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Colorado Springs, Colorado, 80907, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Colorado Springs, Colorado, 80923, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Denver, Colorado, 80218, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Denver, Colorado, 80220, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Englewood, Colorado, 80113, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Lakewood, Colorado, 80228, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Littleton, Colorado, 80120, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Lone Tree, Colorado, 80124, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Longmont, Colorado, 80504, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Pueblo, Colorado, 81003, United States
Rocky Mountain Cancer Centers, LLP
RECRUITING

Thornton, Colorado, 80260, United States
US Oncology Investigational Products Center (IPC)
RECRUITING

Irving, Texas, 75063, United States
US Oncology Investigational Products Center (IPC)
NOT_YET_RECRUITING

Irving, Texas, 75063, United States
Virginia Cancer Specialists, PC
NOT_YET_RECRUITING

Arlington, Virginia, 22201, United States
Virginia Cancer Specialists, PC
NOT_YET_RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Cancer Specialists, PC
NOT_YET_RECRUITING

Manassas, Virginia, 20110, United States
Virginia Cancer Specialists, PC
NOT_YET_RECRUITING

Reston, Virginia, 20190, United States
Virginia Cancer Specialists, PC
NOT_YET_RECRUITING

Woodbridge, Virginia, 22191, United States
Virginia Oncology Associates
NOT_YET_RECRUITING

Chesapeake, Virginia, 23320, United States
Virginia Oncology Associates
NOT_YET_RECRUITING

Hampton, Virginia, 23666, United States
Virginia Oncology Associates
NOT_YET_RECRUITING

Newport News, Virginia, 23606, United States
Virginia Oncology Associates
NOT_YET_RECRUITING

Norfolk, Virginia, 23502, United States
Virginia Oncology Associates
NOT_YET_RECRUITING

Virginia Beach, Virginia, 23456, United States

Conditions

Explore the condition pages connected to this study.

ESOPHAGEAL ADENOCARCINOMA ESOPHAGEAL ADENOCARCINOMA GASTROESOPHAGEAL-JUNCTION CANCER METASTATIC GASTRIC CANCER UNTREATED ADVANCED OR METASTATIC GASTRIC, GASTROESOPHAGEAL JUNCTION, OR ESOPHAGEAL ADENOCARCINOMA