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Could eating sooner after variceal ligation stop rebleeding?

NCT ID NCT07774143

Disease control Sponsor: The First Affiliated Hospital of Zhengzhou University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This trial compares different fasting durations after a procedure to treat bleeding esophageal varices in people with cirrhosis. Some patients will fast for 6 hours, others for 24 or 48 hours, to see if eating earlier affects the chance of rebleeding. The study also looks at hospital stay length, nutrition, and other complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Fasting periods of 6, 24, or 48 hours after the procedure
What this could lead to
If shorter fasting proves safe, patients could recover faster with better nutrition and shorter hospital stays after variceal ligation.
What could go wrong
The trial is early and may not show a clear benefit; shorter fasting could increase rebleeding risk in some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 339 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: -1. The patient must be aged\>18 years; 2. The diagnosis of portal hypertension must be confirmed, with gastroscopy revealing severe esophageal varices and a positive red sign; 3. For patients undergoing endoscopic variceal ligation (EVL) due to esophageal varices (including those with hemorrhage or those eligible for elective ligation), successful intraoperative ligation is achieved (achieving hemostasis or completing the predetermined ligation procedure). 4\. Sign the informed consent form Exclusion Criteria: * 1\. Uncontrolled active bleeding or concurrent bleeding from gastric fundal varices; 2.History of prior TIPS, EVL, or surgical shunt procedures; 3. Presence of severe systemic diseases, such as sepsis, uremia, or advanced hepatocellular carcinoma (HCC); 4.Mechanical ventilation with retained catheter, inability to take oral intake, or significant dysphagia, or a history of major esophageal/gastric surgery that has impaired swallowing function; 5. Severe hepatic failure: Child-Pugh score\>13; profound jaundice (serum bilirubin\>10 mg/dL) accompanied by altered consciousness beyond Stage II or massive ascites; 6.Pregnancy or lactation; 7. Inability to provide informed consent.

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Conditions

The condition(s) this trial relates to.

esophageal varices

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Esophageal varices

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    12 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Huaihe Hospital of Henan University

    RECRUITING

    Kaifeng, China

  • Luohe Central Hospital

    RECRUITING

    Luohe, China

  • Luoyang Central Hospital

    RECRUITING

    Luoyang, China

  • Nanyang Central Hospital

    RECRUITING

    Nanyang, China

  • Sanmenxia Central Hospital

    RECRUITING

    Sanmenxia, China

  • Shangqiu Municipal Hospital

    RECRUITING

    Shangqiu, China

  • The Fifth People's Hospital of Anyang

    RECRUITING

    Anyang, China

  • The First Affiliated Hospital of Xinxiang Medical University

    RECRUITING

    Xinxiang, China

  • The Secend People's Hospital of Jiaozuo

    RECRUITING

    Jiaozuo, China

  • Xuchang Central Hospital

    RECRUITING

    Xuchang, China

  • Zhoukou Central Hospital

    RECRUITING

    Zhoukou, China

  • the First Affiliated Hospital of Zhengzhou University

    RECRUITING

    Zhengzhou, China

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