Simple brush test during endoscopy could spot esophageal cancer risk early

NCT ID NCT06523374

Recruiting now Knowledge-focused Sponsor: University Hospital, Antwerp Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study is testing whether cells collected by brushing the esophagus during a routine endoscopy can be genetically analyzed to better predict cancer risk in people with Barrett's esophagus. Researchers will collect brush samples, biopsies, and blood from 50 patients, then use advanced genetic techniques to see if they can tell high-risk from low-risk cases. The goal is to develop a more cost-effective surveillance strategy and eventually reduce unnecessary procedures while catching cancers earlier.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a simple brush test during endoscopy to better predict which Barrett's esophagus patients are at high risk for cancer, enabling more personalized surveillance.
What could go wrong: This is a very early pilot study with only 50 participants, focused on testing methods rather than proving a new treatment. The proposed risk model may not prove accurate enough in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus Barrett esophagus esophageal adenocarcinoma Esophageal Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BARRETT'S ESOPHAGUS ESOPHAGEAL ADENOCARCINOMA

Contacts and locations

Locations

AZ Delta
RECRUITING

Roeselare, 8800, Belgium
CHU LILLE - Centre Hospitalier Universitaire de Lille
RECRUITING

Lille, 59000, France
IRCCS Ospedale San Raffaele
RECRUITING

Milan, Milano, 20132, Italy
Karolinska University Hospital
RECRUITING

Solna, SE-171 76, Sweden
Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark
Sint-Augustinus Hospital (ZAS)
RECRUITING

Wilrijk, Antwerpen, 2610, Belgium
St James's Hospital
RECRUITING

Dublin, D08 NHY1, Ireland
UZ Gent
RECRUITING

Ghent, 9000, Belgium
University Hospital Antwerp
RECRUITING

Edegem, Antwerpen, 2650, Belgium

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