New drug cocktail aims to tackle tough esophageal cancer
NCT ID NCT06339619
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing a combination of three drugs—adebrelimab, apatinib, and tegafur—in 32 people with advanced esophageal cancer that has not responded to first-line immunotherapy. The goal is to see if this new mix can shrink tumors or slow the disease. Participants will receive the drugs intravenously and orally over several weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- adebrelimab (an immunotherapy drug), apatinib (a targeted therapy), and tegafur (a chemotherapy drug)
- What this could lead to
- If successful, this combination could offer a new treatment option for people with advanced esophageal cancer that has stopped responding to standard immunotherapy.
- What could go wrong
- This is a small, early-phase trial with only 32 participants, so results may not apply to everyone. The combination of drugs may cause significant side effects, and there is no guarantee it will work better than existing options.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
RECRUITINGGuangzhou, Guangdong, 510030, China