New drug targets tough esophageal cancer in early trial
NCT ID NCT07405151
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a drug called I-DXd in 60 people with advanced esophageal cancer that has worsened after prior treatments. I-DXd is designed to attach to cancer cells and deliver a toxic payload to destroy them. The main goal is to see how many patients' tumors shrink or disappear.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ifinatamab deruxtecan (I-DXd)
What this could lead to
If it works, this could offer a new treatment option for advanced esophageal cancer that has stopped responding to other therapies.
What could go wrong
This is an early-phase trial with only 60 participants, so results may not apply broadly. The drug may cause side effects or fail to shrink tumors in many patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Aichi Cancer Center ( Site 2702)
RECRUITINGNagoya, Aichi-ken, 464-8681, Japan
Contact Phone: •••-•••-••••
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Asan Medical Center ( Site 2901)
RECRUITINGSeoul, 05505, South Korea
Contact Phone: •••-•••-••••
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Beijing Cancer Hospital ( Site 2500)
RECRUITINGBeijing, Beijing Municipality, 100142, China
Contact Phone: •••-•••-••••
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Chang Gung Memorial Hospital - Linkou Branch ( Site 3006)
RECRUITINGTaoyuan, 33305, Taiwan
Contact Phone: •••-•••-••••
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Chang Gung Memorial Hospital at Kaohsiung ( Site 3003)
RECRUITINGKaohsiung City, 83301, Taiwan
Contact Phone: •••-•••-••••
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China Medical University Hospital ( Site 3007)
RECRUITINGTaichung, 40447, Taiwan
Contact Phone: •••-•••-••••
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Hopitaux Universitaires de Geneve HUG ( Site 3701)
RECRUITINGGeneva, 1211, Switzerland
Contact Phone: •••-•••-••••
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Kanagawa Cancer Center ( Site 2701)
RECRUITINGYokohama, Kanagawa, 241-8515, Japan
Contact Phone: •••-•••-••••
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Kantonsspital Graubünden-Medizin ( Site 3700)
RECRUITINGChur, Kanton Graubünden, 7000, Switzerland
Contact Phone: •••-•••-••••
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Masarykuv onkologicky ustav ( Site 4000)
RECRUITINGBrno, Brno-mesto, 565 53, Czechia
Contact Phone: •••-•••-••••
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National Cancer Center ( Site 2902)
RECRUITINGGoyang-si, Kyonggi-do, 10408, South Korea
Contact Phone: •••-•••-••••
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National Cancer Center Hospital ( Site 2700)
RECRUITINGChūō, Tokyo, 104-0045, Japan
Contact Phone: •••-•••-••••
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National Cheng Kung University Hospital ( Site 3001)
RECRUITINGTainan, 704, Taiwan
Contact Phone: •••-•••-••••
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National Taiwan University Cancer Center (NTUCC) ( Site 3010)
RECRUITINGTaipei, 106, Taiwan
Contact Phone: •••-•••-••••
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National Taiwan University Hospital ( Site 3000)
RECRUITINGTaipei, 10002, Taiwan
Contact Phone: •••-•••-••••
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Oslo universitetssykehus, Radiumhospitalet ( Site 3501)
RECRUITINGOslo, 0379, Norway
Contact Phone: •••-•••-••••
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Samsung Medical Center ( Site 2900)
RECRUITINGSeoul, 06351, South Korea
Contact Phone: •••-•••-••••
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Taipei Veterans General Hospital ( Site 3005)
RECRUITINGTaipei, 11217, Taiwan
Contact Phone: •••-•••-••••