New cancer drug ABBV-400 enters early human testing
NCT ID NCT06084481
First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 2 times
Summary
This early-phase trial tests an investigational drug called ABBV-400 in about 300 adults with advanced solid tumors, including liver, pancreatic, breast, and ovarian cancers. The study aims to see if the drug can shrink tumors and to check for side effects. Participants receive ABBV-400 alone or with another drug (itraconazole) to understand how the body processes it.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ABBV-400 (an investigational drug given by IV infusion)
- What this could lead to
- If it works, this could point toward a new treatment option for several advanced solid tumors that have not responded to other therapies.
- What could go wrong
- This is a very early Phase 1 trial with a small number of participants. The drug may not shrink tumors or could cause significant side effects. It is too soon to know if it will be effective.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Aichi Cancer Center Hospital /ID# 256679
Nagoya, Aichi-ken, 464-8681, Japan
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Austin Health /ID# 256635
Heidelberg, Victoria, 3084, Australia
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China Medical University Hospital /ID# 256712
Taichung, 40447, Taiwan
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Chris O'Brien Lifehouse /ID# 262765
Camperdown, New South Wales, 2050, Australia
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Chungbuk National University Hospital /ID# 256698
Cheongju-si, North Chungcheong, 28644, South Korea
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City of Hope National Medical Center /ID# 258645
Duarte, California, 91010, United States
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Clinica Universidad de Navarra - Madrid /ID# 264042
Madrid, 28027, Spain
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Clinica Universidad de Navarra - Pamplona /ID# 256703
Pamplona, Navarre, 31008, Spain
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Duke Cancer Center /ID# 255129
Durham, North Carolina, 27710, United States
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E-DA Cancer Hospital /ID# 258880
Kaohsiung City, Kaohsiung, 82445, Taiwan
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Florida Cancer Specialists /ID# 261569
Sarasota, Florida, 34232, United States
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Gyeongsang National University Hospital /ID# 260408
Jinju, Gyeongsangnam-do, 52727, South Korea
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Hadassah Medical Center-Hebrew University /ID# 256655
Jerusalem, 91120, Israel
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Hospital General Universitario Gregorio Maranon /ID# 262816
Madrid, 28007, Spain
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Hospital HM Nou Delfos /ID# 263953
Barcelona, 08023, Spain
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Hospital Quiron Malaga /ID# 263994
Málaga, 29004, Spain
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Hospital Universitario Fundacion Jimenez Diaz /ID# 256702
Madrid, 28040, Spain
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Hospital Universitario HM Sanchinarro /ID# 256701
Madrid, 28050, Spain
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Hospital Universitario Miguel Servet /ID# 256704
Zaragoza, 50009, Spain
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Inje University Haeundae Paik Hospital /ID# 260118
Busan, Busan Gwang Yeogsi, 48108, South Korea
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Inova Schar Cancer Institute - Fairfax - Innovation Park Drive /ID# 262771
Fairfax, Virginia, 22031, United States
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Institut Catala d Oncologia - ICO - Badalona /ID# 263954
Badalona, Barcelona, 08916, Spain
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Korea University Guro Hospital /ID# 256700
Seoul, Seoul Teugbyeolsi, 08308, South Korea
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Kyoto University Hospital /ID# 256680
Kyoto, Kyoto, 606-8507, Japan
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Lifespan Cancer Institute at Rhode Island Hospital /ID# 257693
Providence, Rhode Island, 02903-4923, United States
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Linkou Chang Gung Memorial Hospital /ID# 259420
Taoyuan City, 333, Taiwan
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MD Anderson Cancer Center /ID# 255131
Houston, Texas, 77030, United States
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MUSC Hollings Cancer Center /ID# 257935
Charleston, South Carolina, 29425, United States
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Memorial Sloan Kettering Cancer Center - New York - York Avenue /ID# 255132
New York, New York, 10065, United States
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NHO Nagoya Medical Center /ID# 261001
Nagoya, Aichi-ken, 460-0001, Japan
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National Cancer Center Hospital /ID# 261136
Chuo-Ku, Tokyo, 104-0045, Japan
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National Cancer Center Hospital East /ID# 258934
Kashiwa-shi, Chiba, 277-8577, Japan
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National Taiwan University Hospital /ID# 256713
Taipei, 100, Taiwan
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Northwestern University Feinberg School of Medicine /ID# 257378
Chicago, Illinois, 60611-2927, United States
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Pan American Center for Oncology Trials - Rio Piedras /ID# 262903
Rio Piedras, 00935, Puerto Rico
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Prisma Health /ID# 257697
Greenville, South Carolina, 29605, United States
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Rabin Medical Center. /ID# 256650
Petah Tikva, Central District, 4941492, Israel
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Rambam Health Care Campus /ID# 256649
Haifa, 3109601, Israel
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START Midwest /ID# 256581
Grand Rapids, Michigan, 49546-7062, United States
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Samsung Medical Center /ID# 258933
Seoul, Seoul Teugbyeolsi, 06351, South Korea
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Sarah Cannon Research Institute at HealthONE - Denver /ID# 258926
Denver, Colorado, 80218, United States
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Seoul National University Hospital /ID# 255730
Seoul, Seoul Teugbyeolsi, 03080, South Korea
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Shizuoka Cancer Center /ID# 257789
Sunto-gun, Shizuoka, 411-8777, Japan
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South Texas Accelerated Research Therapeutics /ID# 260404
San Antonio, Texas, 78229, United States
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Tel Aviv Sourasky Medical Center /ID# 258931
Tel Aviv, Tel Aviv, 6423906, Israel
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Tennessee Oncology-Nashville Centennial /ID# 261568
Nashville, Tennessee, 37203-1632, United States
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The Cancer Institute Hospital Of JFCR /ID# 257788
Koto-ku, Tokyo, 135-8550, Japan
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The Chaim Sheba Medical Center /ID# 255731
Ramat Gan, Tel Aviv, 5265601, Israel
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UCSF Medical Center - Mount Zion /ID# 257705
San Francisco, California, 94115, United States
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Univ Hosp Cleveland /ID# 257706
Cleveland, Ohio, 44106, United States
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Univ Texas HSC San Antonio /ID# 257708
San Antonio, Texas, 78229-3901, United States
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University of Chicago Medical Center /ID# 258197
Chicago, Illinois, 60637, United States
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University of Colorado Cancer Center - Cancer Clinical Trials Office /ID# 255128
Aurora, Colorado, 80045-7158, United States
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Washington University-School of Medicine /ID# 257379
St Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could a simple scan and blood test outsmart liver cancer?
- Digital peer support: a new weapon against cancer treatment anxiety?
- Can targeted radiation boost Immunotherapy's power against head and neck cancer?
- Can a new infusion drug shrink Hard-to-Treat tumors?
- Could a vaccine help fight Hard-to-Treat cancers?