Should acid reflux meds be routine after POEM? new trial aims to find out
NCT ID NCT05899842
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two strategies for preventing acid reflux after POEM surgery for achalasia: taking a PPI (Lansoprazole) every day for a year versus taking it only when reflux symptoms occur. About 132 participants will be randomly assigned to one of the two groups. The goal is to see which approach better reduces harmful acid exposure in the esophagus.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Lansoprazole (a protein pump inhibitor)
What this could lead to
If successful, this could establish a standard approach to prevent acid reflux after POEM surgery, improving patient comfort and reducing complications.
What could go wrong
This is a relatively small, single-center trial. The benefit of routine PPI over symptom-based use may be small, and long-term PPI use carries its own risks.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AP-HM
RECRUITINGMarseille, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHU de Montpellier
RECRUITINGMontpellier, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHU de Nîmes
RECRUITINGNîmes, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Clinique mutualiste Beausoleil
RECRUITINGMontpellier, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact