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Shorter surgery may be just as effective for treating achalasia

NCT ID NCT07686471

Disease control Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This trial tests whether a shorter muscle cut during a procedure called POEM works as well as a longer one for people with type II achalasia, a condition where the esophagus fails to push food into the stomach. Fifty participants will be randomly assigned to receive either a short or long myotomy. The study measures symptom improvement, procedure time, complications, and recovery, with follow-up at three months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
per-oral endoscopic myotomy (POEM) procedure
What this could lead to
If short myotomy works as well as long myotomy with fewer complications, it could become the preferred surgical approach for type II achalasia, reducing recovery time and risks.
What could go wrong
This is a small, early-stage trial with only 50 participants, so results may not apply to all patients. The procedure itself carries risks like bleeding, infection, or perforation, and the short myotomy might not relieve symptoms as effectively.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients of all ages were eligible for inclusion in the study with no upper or lower age limits applied . * Both sexes are included . * Type II achalasia patients who are diagnosed by High Resolution. Manometry based on Chicago Classification (v4.0) characterized by (failed esophageal peristalsis , pan-esophageal pressurization in ≥20% of swallows and Integrated Relaxation Pressure (IRP) \>15 mmHg ). * Eckardt score \>3 ( moderate to severe symptoms Exclusion Criteria: * Type I ,type III achalasia \& Non-achalasia spastic motility disorders. * Sigmoid type esophagus (diameter\> 6 cm ). * Esophageal diverticulae . * Presence of large Hiatus Hernia ( \>5cm). * Severe erosive esophagitis (La Grade C or D) or Barrett's Esophagus. * History of previous Heller's myotomy. * Pseudoachalasia due to underlying malignancy. * Severe coagulopathy ( INR\>1.5 or platelets \<50000 ).

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Conditions

The condition(s) this trial relates to.

achalasia Esophageal Achalasia idiopathic achalasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Esophageal achalasia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Assiut university hosoital

    Asyut, 71511, Egypt

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