Shielding immune cells during radiation: a new strategy against esophageal cancer?

This trial is testing whether a special radiation technique, called lymphocyte-sparing radiotherapy, can reduce the drop in immune cells (lymphocytes) that often happens during standard chemoradiation for esophageal cancer. The study will compare this new approach to conventional radiation in patients with locally advanced esophageal squamous cell carcinoma. The goal is to see if protecting these immune cells can lead to better treatment outcomes and fewer side effects.