New drug XB010 shows promise in early trial for Hard-to-Treat cancers

NCT ID NCT06545331

Recruiting now Disease control Sponsor: Exelixis Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 32 times

Summary

This early-stage study tests a new drug called XB010, alone or with another drug (pembrolizumab), in people with advanced solid tumors that have not responded to other treatments. The main goals are to find the safest dose and check for side effects. About 396 adults with cancers like lung, breast, or head and neck cancer are being enrolled.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

Exelixis Clinical Site #1
RECRUITING

Austin, Texas, 78758, United States
Exelixis Clinical Site #10
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Washington D.C., District of Columbia, 20007, United States
Exelixis Clinical Site #11
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Fairfax, Virginia, 22031, United States
Exelixis Clinical Site #12
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Atlanta, Georgia, 30322, United States
Exelixis Clinical Site #13
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London, England, W1G 6AD, United Kingdom
Exelixis Clinical Site #14
RECRUITING

Manchester, England, M20 4BX, United Kingdom
Exelixis Clinical Site #15
RECRUITING

Chicago, Illinois, 60637, United States
Exelixis Clinical Site #16
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London, England, W1T 7HA, United Kingdom
Exelixis Clinical Site #17
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Leicester, England, LE1 5WW, United Kingdom
Exelixis Clinical Site #18
RECRUITING

Orlando, Florida, 32827, United States
Exelixis Clinical Site #19
RECRUITING

Los Angeles, California, 90095, United States
Exelixis Clinical Site #2
RECRUITING

Fairfax, Virginia, 22031, United States
Exelixis Clinical Site #3
RECRUITING

Huntersville, North Carolina, 28078, United States
Exelixis Clinical Site #4
RECRUITING

Irvine, California, 92618, United States
Exelixis Clinical Site #5
RECRUITING

St Louis, Missouri, 63110, United States
Exelixis Clinical Site #6
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Exelixis Clinical Site #7
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Dallas, Texas, 74246, United States
Exelixis Clinical Site #8
RECRUITING

Houston, Texas, 77030, United States
Exelixis Clinical Site #9
RECRUITING

Nashville, Tennessee, 37203, United States

Conditions

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ESOPHAGEAL SQUAMOUS CELL CANCER HEAD AND NECK SQUAMOUS CELL CANCER HEAD AND NECK SQUAMOUS CELL CANCER HORMONE-RECEPTOR-POSITIVE BREAST CANCER LOCALLY ADVANCED OR METASTATIC SOLID TUMORS NSCLC (NON-SMALL CELL LUNG CANCER) TRIPLE-NEGATIVE BREAST CANCER (TNBC)