New drug XB010 takes on advanced cancers in first human trial

NCT ID NCT06545331

Recruiting now Disease control Sponsor: Exelixis Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This early study tests an experimental drug called XB010, alone or combined with the immunotherapy pembrolizumab, in people with advanced solid tumors (like lung, breast, or head and neck cancers) that have stopped responding to other treatments. The main goals are to find a safe dose and check for any signs that the tumors shrink. About 396 adults will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

XB010 (an experimental drug) and pembrolizumab (an immunotherapy drug)

What this could lead to

If successful, this could point toward a new treatment option for people with advanced solid tumors who have run out of standard therapies.

What could go wrong

This is a very early Phase 1 trial, so the drug may not work or may have unexpected side effects. It is also small and not designed to prove effectiveness yet.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

esophageal squamous cell carcinoma head and neck squamous cell carcinoma hormone receptor-positive breast cancer non-small cell lung carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL SQUAMOUS CELL CANCER HEAD AND NECK SQUAMOUS CELL CANCER HORMONE-RECEPTOR-POSITIVE BREAST CANCER LOCALLY ADVANCED OR METASTATIC SOLID TUMORS NSCLC (NON-SMALL CELL LUNG CANCER) TRIPLE NEGATIVE BREAST CANCER (TNBC)

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Baylor University Medical Center
RECRUITING

Dallas, Texas, 75246, United States
Carolina BioOncology Institute
RECRUITING

Huntersville, North Carolina, 28078, United States
City of Hope Orange County Lennar Foundation Cancer Center
RECRUITING

Irvine, California, 91010, United States
Georgetown University Medical Center
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Inova Schar Cancer
RECRUITING

Fairfax, Virginia, 22031, United States
Montefiore Medical Center - Montefiore Medical Park
RECRUITING

The Bronx, New York, 10461, United States
NEXT Austin
RECRUITING

Austin, Texas, 78758, United States
NEXT Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute London
RECRUITING

London, W1G 6AD, United Kingdom
Sarah Cannon Research Institute at Florida Cancer Specialists
RECRUITING

Orlando, Florida, 32827, United States
Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63110, United States
Stephenson Cancer Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
UCLA Department of Medicine - Hematology/Oncology
RECRUITING

Los Angeles, California, 90095, United States
University College London Hospitals NHS Foundation Trust
RECRUITING

London, W1T 7HA, United Kingdom
University Hospitals of Leicester NHS Trust
RECRUITING

Leicester, LE1 5WW, United Kingdom
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States