New targeted therapy combo aims to fight stubborn stomach cancers

NCT ID NCT07431281

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This Phase 3 trial is testing whether a new targeted drug called sonesitatug vedotin, combined with chemotherapy (capecitabine) and possibly an immunotherapy (rilvegostomig), can help people with advanced stomach, gastroesophageal junction, or esophageal cancer that has a specific marker (CLDN18.2) and is HER2-negative. About 2130 participants will be enrolled to see if the treatment improves survival and delays cancer growth. The study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

sonesitatug vedotin (a targeted drug) combined with capecitabine (chemotherapy), with or without rilvegostomig (an immunotherapy)

What this could lead to

If successful, this could provide a new first-line treatment option for people with a specific type of advanced stomach cancer, potentially improving how long they live without their cancer growing.

What could go wrong

This is a large Phase 3 trial, but the drugs are still experimental. Side effects from chemotherapy and targeted therapy are possible, and the combination may not prove more effective than existing treatments.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma Adenocarcinoma Of Esophagus esophageal adenocarcinoma esophageal cancer Esophageal Neoplasms gastric adenocarcinoma gastric cancer gastric neoplasm gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL CANCER GASTRIC CANCER GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

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Mobile, Alabama, 36604, United States
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Anchorage, Alaska, 99508, United States
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Phoenix, Arizona, 85054, United States
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Springdale, Arkansas, 72762, United States
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Duarte, California, 91010, United States
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Fullerton, California, 92835, United States
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La Jolla, California, 92093, United States
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Los Alamitos, California, 90720, United States
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Orange, California, 92868, United States
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Walnut Creek, California, 94598, United States
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Denver, Colorado, 80210, United States
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Lone Tree, Colorado, 80124, United States
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New Haven, Connecticut, 06510, United States
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Newark, Delaware, 19713, United States
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Washington D.C., District of Columbia, 20007, United States
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Fort Myers, Florida, 33901, United States
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Jacksonville, Florida, 32224, United States
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Orlando, Florida, 32806, United States
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St. Petersburg, Florida, 33705, United States
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West Palm Beach, Florida, 33401, United States
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Atlanta, Georgia, 30309, United States
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Atlanta, Georgia, 30322, United States
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Atlanta, Georgia, 30342, United States
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Macon, Georgia, 31201, United States
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Newnan, Georgia, 30265, United States
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Chicago, Illinois, 60637, United States
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Niles, Illinois, 60714, United States
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Zion, Illinois, 60099, United States
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Indianapolis, Indiana, 46260, United States
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Waukee, Iowa, 50263, United States
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Lexington, Kentucky, 40536, United States
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Louisville, Kentucky, 40217, United States
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Boston, Massachusetts, 02114, United States
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Burlington, Massachusetts, 01803, United States
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Worcester, Massachusetts, 01655, United States
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Grand Rapids, Michigan, 49503, United States
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Burnsville, Minnesota, 55337, United States
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Duluth, Minnesota, 55805, United States
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Rochester, Minnesota, 55905, United States
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Kansas City, Missouri, 64132, United States
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St Louis, Missouri, 63110, United States
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Camden, New Jersey, 08103, United States
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East Brunswick, New Jersey, 08816, United States
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Hackensack, New Jersey, 07601, United States
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New Brunswick, New Jersey, 08901, United States
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Summit, New Jersey, 07901, United States
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New York, New York, 10029, United States
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New York, New York, 10032, United States
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New York, New York, 10065, United States
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The Bronx, New York, 10461, United States
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The Bronx, New York, 10468, United States
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White Plains, New York, 10601, United States
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Charlotte, North Carolina, 28204, United States
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Wilmington, North Carolina, 28403, United States
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Winston-Salem, North Carolina, 27103, United States
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Cleveland, Ohio, 44195, United States
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Columbus, Ohio, 43221, United States
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Portland, Oregon, 97213, United States
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Portland, Oregon, 97239, United States
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Hershey, Pennsylvania, 17033, United States
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Philadelphia, Pennsylvania, 19104, United States
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Pittsburgh, Pennsylvania, 15232, United States
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Pittsburgh, Pennsylvania, 15240, United States
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Wilkes-Barre, Pennsylvania, 18711, United States
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York, Pennsylvania, 17403, United States
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Charleston, South Carolina, 29425, United States
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Sioux Falls, South Dakota, 57105, United States
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Memphis, Tennessee, 38104, United States
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Nashville, Tennessee, 37203, United States
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Dallas, Texas, 75235, United States
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Dallas, Texas, 75246, United States
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Sherman, Texas, 75090, United States
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Blacksburg, Virginia, 24060, United States
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Fairfax, Virginia, 22031, United States
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Falls Church, Virginia, 22042, United States
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Fort Belvoir, Virginia, 22060, United States
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Richmond, Virginia, 23219, United States
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Edmonds, Washington, 98026, United States
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Issaquah, Washington, 98029, United States
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Olympia, Washington, 98502, United States
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Seattle, Washington, 98104, United States
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Charleston, West Virginia, 25315, United States
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Milwaukee, Wisconsin, 53226, United States
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Darlinghurst, 2010, Australia
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Garran, 2605, Australia
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Heidelberg, 3084, Australia
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Murdoch, 6150, Australia
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Randwick, 2031, Australia
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Westmead, 2145, Australia
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Linz, 4010, Austria
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Rankweil, 6830, Austria
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Vienna, 1090, Austria
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Wiener Neustadt, 2700, Austria
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Brussels, 1200, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Barretos, 14784-400, Brazil
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Fortaleza, 60336-045, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 91350200, Brazil
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Salvador, 41.950-610, Brazil
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Santa Maria, 97015-450, Brazil
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São Paulo, 01246-000, Brazil
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Vitória, 29043-260, Brazil
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Edmonton, Alberta, T6G 1Z2, Canada
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Abbotsford British Columbia, British Columbia, V2S0C2, Canada
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Vancouver, British Columbia, VSZ 4E6, Canada
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Winnipeg, Manitoba, R3E 0V9, Canada
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Moncton, New Brunswick, E1C 2Z3, Canada
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Barrie, Ontario, L4M 6M2, Canada
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Brampton, Ontario, L6R 3J7, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Sault Ste. Marie, Ontario, P6A 0A8, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H3A 1A1, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Beijing, 100032, China
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Beijing, 100050, China
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Beijing, 100142, China
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Beijing, 102200, China
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Changde, 415000, China
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Chengdu, 610041, China
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Chengdu, 610041, China
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Chongqing, 400016, China
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Fuzhou, 350005, China
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Fuzhou, 350011, China
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Guangzhou, 510655, China
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Hangzhou, 310003, China
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Hangzhou, 310014, China
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Hangzhou, 310020, China
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Harbin, 150081, China
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Hefei, 230031, China
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Hohhot, 010020, China
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Jinan, 2501117, China
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Kunming, 650118, China
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Lanzhou, 730000, China
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Linhai, 317000, China
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Linyi, 276000, China
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Nanchang, 330000, China
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Nanchang, 330029, China
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Nanjing, 2100008, China
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Nanjing, 210029, China
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Nanning, 530021, China
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Nantong, 226361, China
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Shanghai, 200025, China
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Shanghai, 200127, China
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Shanghai, 20032, China
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Shantou, 515041, China
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Shenyang, 110016, China
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Shenzhen, 518036, China
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Tianjin, 300050, China
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Wuhan, 430030, China
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Wuhan, 430079, China
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Xi'an, 710068, China
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Xiamen, 361003, China
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Xingtai, 054031, China
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Xuzhou, 221009, China
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Yinchuan, 750004, China
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Zhengzhou, 450008, China
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Bordeaux, 33000, France
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Caen, 41076, France
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Lyon, 69373, France
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Marseille, 13273, France
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Rennes, 35000, France
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Villejuif, 94805, France
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Augsburg, 86156, Germany
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Bad Saarow, 15526, Germany
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Berlin, 13353, Germany
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Bonn, 53127, Germany
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Dresden, 01370, Germany
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Essen, 45122, Germany
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Essen, 45130, Germany
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Frankfurt, 60488, Germany
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Freiburg im Breisgau, 79106, Germany
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Hamburg, 20249, Germany
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Heidelberg, 69120, Germany
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Heilbronn, 74078, Germany
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Leipzig, 04103, Germany
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Lichtenberg, 10365, Germany
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Magdeburg, 39120, Germany
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Mainz, 55131, Germany
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Mannheim, 68167, Germany
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Marburg, 35043, Germany
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Minden, 32429, Germany
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Moers, 47441, Germany
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München, 81657, Germany
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Stuttgart, 70376, Germany
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Ulm, 89081, Germany
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Budapest, 1083, Hungary
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Budapest, 1122, Hungary
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Debrecen, 4032, Hungary
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Győr, 9024, Hungary
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Gyula, 5700, Hungary
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Nyíregyháza, 4400, Hungary
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Pécs, 7624, Hungary
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Zalaegerszeg, 8900, Hungary
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Ahmedabad, 380060, India
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Bhubaneswar, 751019, India
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Hyderabad, 500032, India
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Mohali, 140901, India
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Mohali, 160055, India
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Mumbai, 400012, India
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New Delhi, 110017, India
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New Delhi, 110060, India
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Varanasi, 221005, India
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Vijayawada, 520002, India
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Visakhapatnam, 530053, India
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Meldola, 47014, Italy
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Milan, 20133, Italy
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Milan, 20141, Italy
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Milan, 20162, Italy
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Padova, 35128, Italy
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Rozzano, 20089, Italy
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Tricase, 73039, Italy
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Bunkyō City, 113-8677, Japan
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Chūōku, 104-0045, Japan
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Hirakata-shi, 573-1191, Japan
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Kashiwa, 277-8577, Japan
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Kitaadachi-gun, 362-0806, Japan
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Kōtoku, 135-8550, Japan
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Kurashiki-shi, 710-8602, Japan
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Nagoya, 464-8681, Japan
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Niigata, 951-8566, Japan
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Osaka, 541-8567, Japan
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Ota-shi, 373-8550, Japan
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Sagamihara-shi, 252-0375, Japan
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Sakai, 590-0197, Japan
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Sendai, 980-8574, Japan
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Shimotsuke-shi, 329-0498, Japan
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Sunto-gun, 411-8777, Japan
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Yokohama, 232-0024, Japan
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Yokohama, 241-8515, Japan
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Groningen, 9713 GZ, Netherlands
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Rotterdam, 3015 GD, Netherlands
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Tilburg, 5022 GC, Netherlands
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Gdansk, 80-219, Poland
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Koszalin, 75-581, Poland
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Krakow, 31-501, Poland
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Lublin, 20-080, Poland
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Olsztyn, 10-228, Poland
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Warsaw, 02-034, Poland
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San Juan, 00921, Puerto Rico
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Daegu, 41404, South Korea
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Hwasun-gun, 58128, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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NOT_YET_RECRUITING

Seoul, 06591, South Korea
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Barcelona, 08035, Spain
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Barcelona, 8036, Spain
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Madrid, 28041, Spain
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Pamplona, 31008, Spain
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Santander, 39008, Spain
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Santiago de Compostela, 15706, Spain
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NOT_YET_RECRUITING

Valencia, 46010, Spain
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 83301, Taiwan
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Taichung, 40447, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 112, Taiwan
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Taoyuan, 333, Taiwan
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NOT_YET_RECRUITING

Bangkok, 10210, Thailand
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Bangkok, 10700, Thailand
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Dusit, 10300, Thailand
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NOT_YET_RECRUITING

Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Muang, 22000, Thailand
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Muang, 70000, Thailand
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Ankara, 06530, Turkey (Türkiye)
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Antalya, 07100, Turkey (Türkiye)
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Istanbul, 34098, Turkey (Türkiye)
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Istanbul, 34854, Turkey (Türkiye)
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Medreseboğazı, 01250, Turkey (Türkiye)
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Şahinbey, 27310, Turkey (Türkiye)
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NOT_YET_RECRUITING

Cambridge, CB2 0QQ, United Kingdom
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RECRUITING

Dundee, DD1 9SY, United Kingdom
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NOT_YET_RECRUITING

Leeds, LS9 7TF, United Kingdom
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NOT_YET_RECRUITING

London, EC1A 7BE, United Kingdom
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RECRUITING

Manchester, M20 4BX, United Kingdom
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NOT_YET_RECRUITING

Oxford, OX3 7LE, United Kingdom