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A tiny chest incision, a beating heart: can a new technique fix leaky valves without open surgery?

NCT ID NCT07726173

Recruiting now Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial tests a new minimally invasive procedure called TRANSOM for people with a leaky mitral valve, a condition where the valve doesn't close properly. Instead of opening the chest, surgeons make a small incision between the ribs and insert a tube directly into the beating heart to place new cords that help the valve close. The study will evaluate whether this technique is safe and effective compared to standard open-heart surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a minimally invasive surgical technique called TRANSOM that repairs the mitral valve through a small chest incision while the heart is still beating
What this could lead to
If successful, this technique could offer a less invasive alternative to open-heart surgery for repairing leaky mitral valves, potentially reducing recovery time and complications.
What could go wrong
This is an early-stage trial testing a new surgical approach, so its safety and effectiveness are not yet proven. Risks include bleeding, stroke, infection, and the need for additional procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastroesophageal reflux disease mitral valve insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MITRAL VALVE (MV) REGURGITATION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Johns Hopkins Hospital

    RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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