New antibody therapy targets Hard-to-Treat cancers in early trial
NCT ID NCT06005493
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an experimental drug called AZD5863 in adults with advanced stomach, gastro-esophageal junction, pancreatic, or esophageal cancers that have spread. The drug is a bispecific antibody designed to bring immune cells close to cancer cells to attack them. The main goals are to check safety and find the right dose, while also seeing if it shrinks tumors.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Research Site
RECRUITINGJacksonville, Florida, 32224, United States
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Research Site
RECRUITINGRochester, Minnesota, 55905, United States
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Research Site
WITHDRAWNNew York, New York, 10065, United States
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Research Site
RECRUITINGBeijing, 100142, China
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Research Site
RECRUITINGBeijing, 101199, China
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Research Site
RECRUITINGShandong, China
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Research Site
RECRUITINGToulouse, 31059, France
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Research Site
RECRUITINGVillejuif, 94805, France
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Research Site
RECRUITINGChūōku, 104-0045, Japan
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Research Site
RECRUITINGKashiwa, 227-8577, Japan
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Research Site
RECRUITINGKōtoku, 135-8550, Japan
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Research Site
RECRUITINGAmsterdam, 1081 HV, Netherlands
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Research Site
RECRUITINGGroningen, 9713 GZ, Netherlands
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Research Site
RECRUITINGRotterdam, 3015 GD, Netherlands
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Research Site
RECRUITINGSeoul, 03080, South Korea
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Research Site
RECRUITINGSeoul, 03722, South Korea
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Research Site
RECRUITINGSeoul, 05505, South Korea
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Research Site
RECRUITINGSeoul, 06351, South Korea
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Research Site
RECRUITINGKaohsiung City, 80756, Taiwan
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Research Site
RECRUITINGTainan, 70403, Taiwan
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Research Site
RECRUITINGTaoyuan, 00333, Taiwan
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Research Site
RECRUITINGDundee, DD1 9SY, United Kingdom
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Research Site
RECRUITINGLondon, E1 1BB, United Kingdom
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Research Site
RECRUITINGMetropolitan Borough of Wirral, CH63 4JY, United Kingdom
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Research Site
RECRUITINGOxford, OX3 7LE, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Triple-Drug attack slow down stomach cancer?
- Can a Three-Drug cocktail shrink stomach tumors before surgery?
- Can a new nucleotide analogue boost cancer treatment?
- Can High-Dose vitamin c boost Chemo's punch against pancreatic cancer?
- Can a less extensive stomach surgery preserve appetite better?
- Can a vaccine stop stomach cancer from coming back?