New drug YL201 takes on tough esophageal cancer

NCT ID NCT07487896

Recruiting now Disease control Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This large Phase 3 trial tests a new drug called YL201 against standard chemotherapy in 440 people with advanced esophageal cancer that has worsened after initial treatment. YL201 is a targeted therapy designed to deliver chemo directly to cancer cells. The study aims to see if it helps people live longer and with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: YL201 (a targeted drug that delivers chemotherapy to cancer cells)
What this could lead to: If it works, this could offer a new treatment option for people with advanced esophageal cancer when standard therapy stops working.
What could go wrong: This is an early-stage Phase 3 trial, so results are not yet known. The drug may not work better than current chemo and could have side effects like infusion reactions or organ damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

esophageal squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED ESOPHAGEAL SQUAMOUS CELL CARCINOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

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Jinan, Shandong, 250117, China
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Anyang, Henan, China
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Zhengzhou, Henan, China
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Zhengzhou, Henan, China
105
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Luoyang, Henan, China
106
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Shanghai, Shanghai Municipality, China
107
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Nanjing, Jiangsu, China
108
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Hangzhou, Zhejiang, China
109
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Hangzhou, Zhejiang, China
110
NOT_YET_RECRUITING

Fuzhou, Fujian, China
111
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Chengdu, Sichuan, China
112
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Nanning, Guangxi, China
113
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Wuhan, Hubei, China
114
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Wuhan, Hubei, China
115
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Kunming, Yunnan, China
116
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Chengdu, Sichuan, China
117
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Nanchang, Jiangxi, China
118
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Chengdu, Sichuan, China
119
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Chongqing, Chongqing Municipality, China
120
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Chongqing, Chongqing Municipality, China
121
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Nanchang, Jiangxi, China
122
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Harbin, Heilongjiang, China
123
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Taiyuan, Shanxi, China
124
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Tianjin, Tianjin Municipality, China
125
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Changchun, Jilin, China
126
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Shenyang, Niaoning, China
127
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Xi’an, Shanxi, China
128
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Jilin City, Jilin, China
129
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Beijing, Beijing Municipality, China
130
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Ürümqi, Xinjiang, China
132
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Nanyang, Henan, China
133
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Hefei, Anhui, China
134
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Shanghai, Shanghai Municipality, China
135
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Bengbu, Anhui, China
136
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Xuzhou, Jiangsu, China
137
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Qingdao, Shandong, China
138
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Linyi, Shandong, China
139
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Jinan, Shandong, China
140
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Suzhou, Jiangsu, China
141
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Linyi, Shandong, China
142
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Zhengzhou, Henan, China
143
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Hefei, Anhui, China
144
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Anqing, Anhui, China
145
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Xiamen, Fujian, China
146
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Suining, Sichuan, China
147
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Fuzhou, Fujian, China
148
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Wuhan, Hubei, China
149
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Guangzhou, Guangdong, China
150
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Nanning, Guangxi, China
151
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Changsha, Hunan, China
152
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Nanchong, Sichuan, China
153
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Mianyang, Sichuan, China
154
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Guangzhou, Guangdong, China
155
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Yichang, Hubei, China
156
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Shijiazhuang, Hebei, China
157
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Shenyang, Niaoning, China
158
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Handan, Hebei, China
159
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Shijiazhuang, Hebei, China
160
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Shenyang, Niaoning, China
161
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Beijing, Beijing Municipality, China
162
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Xi’an, Shanxi, China
163
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Yinchuan, Ningxia, China
165
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Huai'an, Jiangsu, China
166
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Tengzhou, Shandong, China
167
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Tai’an, Shandong, China
168
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Meizhou, Guangzhou, China
169
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Shantou, Guangzhou, China
170
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Harbin, Heilongjiang, China
171
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Taizhou, Jiangsu, China
172
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Shanghai, Shanghai Municipality, China
173
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Shanghai, Shanghai Municipality, China
174
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Hangzhou, Zhejiang, China
175
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Lanzhou, Gansu, China
176
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Handan, Hebei, China
177
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Nantong, Jiangsu, China
178
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Jinan, Shandong, China
179
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Wenzhou, Zhejiang, China
180
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Langfang, Hebei, China
182
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Changsha, Hunan, China
183
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Beijing, Beijing Municipality, China
184
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Foshan, Guangzhou, China

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