New hope for tough esophageal cancer: drug combo targets gene mutations

NCT ID NCT07446335

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a new combination of drugs (anlotinib hydrochloride plus benmelstobart) works better than the current standard treatment (toripalimab plus chemotherapy) for people with advanced esophageal cancer that has certain gene mutations. The trial will include 578 adults who have not had prior treatment for advanced disease. The main goals are to see if the new combo helps people live longer without their cancer growing and to check for side effects.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, China

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Other studies related to the condition(s) this trial covers.