New drug aims to stop nighttime heartburn in its tracks

NCT ID NCT07268820

Recruiting now Symptom relief Sponsor: Incheon St.Mary's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a newer drug, zastaprazan, can relieve nighttime heartburn better than the standard drug esomeprazole in people with erosive GERD. About 160 Korean adults with nighttime heartburn for over 3 months will take one of the two drugs and report their sleep quality. The goal is to see if zastaprazan helps more people sleep without heartburn-related disturbances.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Zastaprazan (a P-CAB drug) and esomeprazole (a PPI drug)
What this could lead to: If zastaprazan works better, it could offer a new option for people with GERD who struggle with nighttime heartburn and sleep problems.
What could go wrong: This is a small, early-phase trial in one country, so results may not apply to everyone. It compares two similar drugs, so the difference may be small or none.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastroesophageal reflux disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GERD

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Catholic University of Korea, Incheon ST. Mary's Hospital
RECRUITING

Incheon, South Korea

Contact Phone: •••-•••-•••• Email: •••••@•••••
Chonnam National University Hospital
RECRUITING

Gwangju, South Korea
Gangnam Severance Hospital
RECRUITING

Seoul, South Korea
Hallym University Chuncheon Sacred Heart Hospital
RECRUITING

Chuncheon, South Korea
Korea University Ansan Hospital
RECRUITING

Ansan, South Korea
Kyung Hee University Hospital
RECRUITING

Seoul, South Korea
Kyungpook National University Chilgok Hospital
RECRUITING

Chilgok, South Korea
Pusan National University Hospital
RECRUITING

Busan, South Korea
Pusan National University Yangsan Hospital
RECRUITING

Yangsan, South Korea
Soonchunhyang University Hospital
RECRUITING

Seoul, South Korea

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