GERD

This study tests a minimally invasive procedure called TIF for people with chronic heartburn and regurgitation (GERD) who don't get relief from medication. It involves 20 Asian adults and aims to see if the procedure safely reduces symptoms and the need for daily pills. Participa…

This study tests whether a newer acid-reducing drug, Vonaprazan, works better than the standard drug Esomeprazole for healing acid reflux damage in people who had POEM surgery for achalasia. About 300 adults with moderate to severe esophagitis will take one of the two drugs for 8…

This study tests whether using a special mesh (Ovitex) during hernia repair surgery lowers the chance of the hernia coming back within two years, compared to using stitches alone. About 164 adults with large hiatal hernias will take part. The goal is to find the best way to keep …

This study will test a new FDA-approved device that measures electrical resistance in the esophagus to diagnose GERD and eosinophilic esophagitis. Researchers want to see if it can replace multiple tests, saving time and money. About 50 adults with chronic reflux or swallowing pr…

This program gives domperidone to 20 teens aged 12-21 who have severe stomach or reflux symptoms that didn't get better with standard treatments. The goal is to see if the drug can reduce their symptoms. It is a compassionate-use program, meaning it provides access to a treatment…

This study tests two doses of vonaprazan (10 mg and 20 mg) against esomeprazole (40 mg) to see which heals moderate-to-severe acid reflux damage in the esophagus after 8 weeks. About 414 adults with confirmed reflux esophagitis will take one pill daily. The goal is to find a more…

This study compares two medications, zastaprazan and esomeprazole, to see which one better relieves nighttime heartburn in people with erosive GERD. About 160 Korean adults with nighttime heartburn for over 3 months will take one of the drugs and report their sleep quality. The g…

This study tests if special breathing exercises can help people with GERD (chronic acid reflux). 42 adults with GERD will be randomly assigned to do diaphragmatic breathing, use a breathing device, or receive standard care for 6 weeks. Researchers will measure changes in symptoms…

This study compares a new melt-in-mouth version of Trimedat (76.95 mg) to the standard tablet (100 mg) in 36 healthy adults. Researchers want to see if the new form is absorbed similarly and is safe. The goal is to offer a more convenient option for people with digestive issues l…

This study aims to understand how the upper throat and esophagus work together to prevent stomach contents from flowing back into the throat in people with GERD. Researchers will measure pressure and use video to detect when acid reaches the throat. The study involves 300 adults …

This study is a registry that will gather information from up to 10,000 adults with esophageal problems like GERD, achalasia, or swallowing difficulties. Researchers will collect data from standard tests such as manometry and pH monitoring to better understand these conditions. T…